Structure information

PAR1

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8XOS

SPECIES

Homo sapiens

RESOLUTION

3.200

PREFERRED CHAIN

R

REFERENCE

PUBLICATION DATE

Sept. 18, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Tethered agonist A86 N-term hydrophobic
Tethered agonist F87 N-term Van der Waals
Tethered agonist F87 N-term polar (hydrogen bond with backbone)
Tethered agonist I88 N-term Van der Waals
Tethered agonist A92 N-term hydrophobic
Tethered agonist Y95 N-term hydrophobic
Tethered agonist L96 N-term Van der Waals
Tethered agonist L96 N-term hydrophobic
Tethered agonist H255 45.51x51 ECL2 polar (hydrogen bond with backbone)
Tethered agonist H255 45.51x51 ECL2 Van der Waals
Tethered agonist D256 45.52x52 ECL2 polar (hydrogen bond with backbone)
Tethered agonist D256 45.52x52 ECL2 Van der Waals
Tethered agonist V257 ECL2 polar (hydrogen bond with backbone)
Tethered agonist V257 ECL2 Van der Waals
Tethered agonist L258 ECL2 Van der Waals
Tethered agonist L258 ECL2 polar (hydrogen bond with backbone)
Tethered agonist E260 ECL2 polar (charge-assisted hydrogen bond)
Tethered agonist L263 ECL2 hydrophobic
Tethered agonist L263 ECL2 Van der Waals
Tethered agonist H336 6.58x58 TM6 polar (hydrogen bond)
Tethered agonist H336 6.58x58 TM6 polar (hydrogen bond)
Tethered agonist Y337 6.59x59 TM6 polar (hydrogen bond)
Tethered agonist E347 7.29x28 TM7 polar (charge-assisted hydrogen bond)
Tethered agonist Y350 7.32x31 TM7 aromatic (edge-to-face)
Tethered agonist Y350 7.32x31 TM7 Van der Waals
Tethered agonist F351 7.33x32 TM7 hydrophobic

Ligands

Tethered agonist

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Residue Diagrams

I N L P L S V V F V G T Y V S P V F L T 1 L H L A T A D V L F V S V L P F K I S Y 2 V T M L L I S A Y M N C Y F A A T V F R 3 A S F T C L A I W A L A I A G V V P L 4 Y C V T S I I L P V F F F V A S F A S F 5 S A A V F C I F I I C F G P T N V L L I A 6 L P D I C C S I S S V C V C L L Y A F 7
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ICL1 M K V K ICL1ECL1 G S D W Q F ECL1ICL2 P M Q S L S W R ICL2ECL2 E Q T I Q V P G L N I T T C H D V L N E T L L ECL2ICL3 S A V A ICL3ECL3 S H T S T ECL3N-term M G P R R L L L V A A C F S L C G P L L S A R T R A R R P E S K A T N A T L D P R S F L L R N P N D K Y E P F W E D E E K N E S G L T E Y R L V S I N K S S P L Q K Q L P A F I S E D A S G Y L T S N-termC-term E S S D P S S Y N S S G Q L M A S K M D T C S S N L N N S I Y K K L L T C-term S W L T L F V P S V Y T G V F V V S L P L N I M A I V V F I L K K P A V V Y M L H L A T A D V L F V S V L P F K I S Y Y F S G S E L C R F V T A A F Y C N M Y A S I L L M T V I S I D R F L A V V Y T L G R A S F T C L A I W A L A I A G V V P L L L K E G Y Y A Y Y F S A F S A V F F F V P L I I S T V C Y V S I I R C L S S N R S K K S R A L F L S A A V F C I F I I C F G P T N V L L I A H Y S F L T E A A Y F A Y L L C V C V S S I S C C I D P L I Y Y Y A S S E V Y S K C Q R Y I L C C
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Residue Table


GPCRdb(A)
GPCRdb(A)
PAR1
ECL2
45x51 45.51x51 H255
45x52 45.52x52 D256
TM6
6x58 6.58x58 H336
6x59 6.59x59 Y337
TM7
7x28 7.29x28 E347
7x31 7.32x31 Y350
7x32 7.33x32 F351