PAR1 - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8XOS

RESOLUTION

3.2 Å

REFERENCE

PUBLICATION DATE

Sept. 18, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

54 interactions (Click to see)

LIGANDS

Tethered agonist - Agonist

PHYSIOLOGICAL LIGANDS

thrombin



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 R 214 34x57 G.H5 C 351 G.H5.23
Hydrophobic ICL2 R 214 34x57 G.H5 C 351 G.H5.23
Van-der-waals ICL2 R 214 34x57 G.H5 C 351 G.H5.23
Hydrophobic ICL2 P 207 34x50 G.H5 I 344 G.H5.16
Polar C-term S 375 - G.H5 G 352 G.H5.24
Hydrophobic C-term S 375 - G.H5 G 352 G.H5.24
Van-der-waals C-term S 375 - G.H5 G 352 G.H5.24
Hydrophobic TM3 R 200 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 200 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM3 A 203 3x53 G.H5 C 351 G.H5.23
Polar ICL2 L 211 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 L 211 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 L 211 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic TM5 L 297 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 297 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL2 P 207 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL2 M 208 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 M 208 34x51 G.H5 I 343 G.H5.15
Hydrophobic ICL2 P 207 34x50 G.H5 T 340 G.H5.12
Hydrophobic TM6 A 311 6x34 G.H5 L 348 G.H5.20
Hydrophobic TM6 L 314 6x37 G.H5 L 353 G.H5.25
Polar ICL2 S 212 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 S 212 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 S 212 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 R 310 6x33 G.H5 F 354 G.H5.26
Ionic ICL2 R 214 34x57 G.H5 D 350 G.H5.22
Polar ICL2 R 214 34x57 G.H5 D 350 G.H5.22
Polar TM3 A 203 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 203 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 203 3x53 G.H5 N 347 G.H5.19
Polar ICL3 N 304 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 N 304 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 N 304 - G.H5 D 341 G.H5.13
Hydrophobic TM2 A 137 2x39 G.H5 D 350 G.H5.22
Polar ICL2 S 210 34x53 G.H5 N 347 G.H5.19
Ionic TM2 K 135 2x37 G.H5 D 350 G.H5.22
Polar TM2 K 135 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 K 135 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 K 135 2x37 G.H5 D 350 G.H5.22
Hydrophobic ICL2 L 211 34x54 G.H5 I 343 G.H5.15
Hydrophobic ICL2 M 208 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 M 208 34x51 G.S3 L 194 G.S3.01
Hydrophobic ICL2 M 208 34x51 G.H5 T 340 G.H5.12
Polar TM3 R 200 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 200 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM6 A 311 6x34 G.H5 L 353 G.H5.25
Hydrophobic ICL3 S 306 - G.H5 K 345 G.H5.17
Hydrophobic ICL3 R 305 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 R 305 - G.S6 Y 320 G.S6.02
Hydrophobic TM2 A 137 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM3 V 204 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 204 3x54 G.H5 L 348 G.H5.20
Polar ICL2 R 214 34x57 G.H5 N 347 G.H5.19
Hydrophobic ICL2 M 208 34x51 G.H5 F 336 G.H5.08