Structure information

SST5 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8ZBE

SPECIES

Homo sapiens

RESOLUTION

3.240

PREFERRED CHAIN

A

REFERENCE

10.1038/S41401-024-01314-8

PUBLICATION DATE

July 10, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Octreotide Q123 3.36x36 TM3 polar (hydrogen bond)
Octreotide Q123 3.36x36 TM3 Van der Waals
Octreotide F124 3.37x37 TM3 Van der Waals
Octreotide F124 3.37x37 TM3 hydrophobic
Octreotide N187 45.51x51 ECL2 Van der Waals
Octreotide S189 ECL2 Van der Waals
Octreotide W190 ECL2 Van der Waals
Octreotide G198 5.35x36 TM5 Van der Waals
Octreotide F201 5.38x39 TM5 hydrophobic
Octreotide I202 5.39x40 TM5 hydrophobic
Octreotide I202 5.39x40 TM5 Van der Waals
Octreotide T205 5.42x43 TM5 Van der Waals
Octreotide F264 6.51x51 TM6 hydrophobic
Octreotide F264 6.51x51 TM6 Van der Waals
Octreotide N268 6.55x55 TM6 polar (hydrogen bond)
Octreotide N268 6.55x55 TM6 Van der Waals
Octreotide N271 6.58x58 TM6 polar (hydrogen bond)
Octreotide N271 6.58x58 TM6 polar (hydrogen bond)

Ligands

Octreotide

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Residue Diagrams

T N G G L G A A C V L L Y L V P V L V A 1 L N L A V A D V L Y M L G L P F L A T Q 2 V T L C F V S T F Q N V G D L T M V L R 3 A K L A S A A A W V L S L C M S L P L 4 Y C L C I V L L P A F F G L V A T Y I I F 5 L V V V L V F A G C W L P F F T V N I V 6 V P N A C S N A Y S L I V V F F Y L G 7
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ICL1 A K M K ICL1ECL1 S F W P F ECL1ICL2 P L S S A R W R ICL2ECL2 D V Q E G G T C N A S W P E ECL2ICL3 G C V R ICL3ECL3 A L P Q E P A ECL3N-term M E P L F P A S T P S W N A S S P G A A S G G G D N R T L V G P A P S A N-termC-term L R K G S G A K D A D A T E P R P D R I R Q Q Q E A T P P A H R A A A N G L M Q T S K L C-term G A R A V L V P V L Y L L V C A A G L G G N T L V I Y V V L R F T V T N I Y I L N L A V A D V L Y M L G L P F L A T Q N A A G P V L C R L V M T L D G V N Q F T S V F C L T V M S V D R Y L A V V H R P R V A K L A S A A A W V L S L C M S L P L L V F A P V G L W G A V F I I Y T A V L G F F A P L L V I C L C Y L L I V V K V R A A G V R V R R S E R K V T R M V L V V V L V F A G C W L P F F T V N I V N L A V S A G L Y F F V V I L S Y A N S C A N P V L Y G F L S D N F Q K F R Q S V L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
SST5 receptor
TM3
3x36 3.36x36 Q123
3x37 3.37x37 F124
ECL2
45x51 45.51x51 N187
TM5
5x36 5.35x36 G198
5x39 5.38x39 F201
5x40 5.39x40 I202
5x43 5.42x43 T205
TM6
6x51 6.51x51 F264
6x55 6.55x55 N268
6x58 6.58x58 N271