SST5 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.2 Å

REFERENCE

PUBLICATION DATE

July 10, 2024

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

Octreotide - Agonist

PHYSIOLOGICAL LIGANDS

cortistatin-14, SRIF-14, CST-17, SRIF-28



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM3 V 141 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 141 3x54 G.H5 L 348 G.H5.20
Polar ICL2 L 145 - G.hns1 R 32 G.hns1.03
Polar H8 N 310 8x49 G.H5 K 349 G.H5.21
Hydrophobic H8 N 310 8x49 G.H5 K 349 G.H5.21
Van-der-waals H8 N 310 8x49 G.H5 K 349 G.H5.21
Hydrophobic TM2 T 75 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 T 75 2x39 G.H5 C 351 G.H5.23
Polar ICL3 R 239 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 R 239 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 R 239 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM3 V 141 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 V 141 3x54 G.H5 I 344 G.H5.16
Hydrophobic TM5 Y 221 5x58 G.H5 L 353 G.H5.25
Hydrophobic TM6 V 246 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 M 249 6x36 G.H5 L 353 G.H5.25
Polar H8 S 308 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 S 308 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 S 308 8x47 G.H5 G 352 G.H5.24
Hydrophobic ICL2 A 148 - G.HN E 28 G.HN.52
Hydrophobic TM3 V 141 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM3 V 141 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 V 141 3x54 G.H5 C 351 G.H5.23
Polar H8 N 310 8x49 G.H5 D 350 G.H5.22
Van-der-waals H8 N 310 8x49 G.H5 D 350 G.H5.22
Hydrophobic TM5 V 228 5x65 G.H5 I 344 G.H5.16
Van-der-waals TM5 V 228 5x65 G.H5 I 344 G.H5.16
Hydrophobic TM6 V 250 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM3 A 140 3x53 G.H5 C 351 G.H5.23
Polar TM3 A 140 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 140 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 140 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM5 I 224 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 I 224 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM4 R 152 4x38 G.HN R 24 G.HN.48
Polar TM3 R 137 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 137 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 137 3x50 G.H5 C 351 G.H5.23