Structure information

QRFP receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8ZH8

SPECIES

Homo sapiens

RESOLUTION

3.190

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-024-49030-5

PUBLICATION DATE

July 3, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
QRF-amide A3 N-term polar (hydrogen bond with backbone)
QRF-amide A3 N-term Van der Waals
QRF-amide L4 N-term Van der Waals
QRF-amide N5 N-term polar (hydrogen bond with backbone)
QRF-amide N5 N-term Van der Waals
QRF-amide N5 N-term polar (hydrogen bond)
QRF-amide I6 N-term Van der Waals
QRF-amide H18 N-term Van der Waals
QRF-amide L20 N-term Van der Waals
QRF-amide L20 N-term hydrophobic
QRF-amide F25 N-term hydrophobic
QRF-amide F25 N-term Van der Waals
QRF-amide Y29 N-term polar (hydrogen bond)
QRF-amide Y29 N-term Van der Waals
QRF-amide L31 N-term Van der Waals
QRF-amide L31 N-term hydrophobic
QRF-amide R32 N-term Van der Waals
QRF-amide R32 N-term polar (hydrogen bond with backbone)
QRF-amide P33 N-term Van der Waals
QRF-amide P33 N-term polar (hydrogen bond with backbone)
QRF-amide L34 N-term polar (hydrogen bond with backbone)
QRF-amide L34 N-term Van der Waals
QRF-amide V35 N-term Van der Waals
QRF-amide V35 N-term hydrophobic
QRF-amide Y36 N-term Van der Waals
QRF-amide Y36 N-term polar (hydrogen bond with backbone)
QRF-amide T37 N-term Van der Waals
QRF-amide P38 N-term Van der Waals
QRF-amide P38 N-term hydrophobic
QRF-amide C98 2.57x56 TM2 Van der Waals
QRF-amide V101 2.60x59 TM2 hydrophobic
QRF-amide V101 2.60x59 TM2 Van der Waals
QRF-amide T102 2.61x60 TM2 Van der Waals
QRF-amide L104 2.63x62 TM2 Van der Waals
QRF-amide Q105 2.64x63 TM2 polar (hydrogen bond)
QRF-amide Q105 2.64x63 TM2 Van der Waals
QRF-amide Q105 2.64x63 TM2 polar (hydrogen bond)
QRF-amide S108 ECL1 Van der Waals
QRF-amide D109 ECL1 polar (hydrogen bond with backbone)
QRF-amide D109 ECL1 Van der Waals
QRF-amide N110 23.49x49 ECL1 Van der Waals
QRF-amide W111 23.50x50 ECL1 Van der Waals
QRF-amide W111 23.50x50 ECL1 aromatic (edge-to-face)
QRF-amide P122 3.29x29 TM3 hydrophobic
QRF-amide P122 3.29x29 TM3 Van der Waals
QRF-amide Q125 3.32x32 TM3 Van der Waals
QRF-amide Q125 3.32x32 TM3 polar (hydrogen bond)
QRF-amide V129 3.36x36 TM3 hydrophobic
QRF-amide Q184 ECL2 polar (hydrogen bond)
QRF-amide Q184 ECL2 Van der Waals
QRF-amide K189 ECL2 polar (charge-assisted hydrogen bond)
QRF-amide C200 ECL2 Van der Waals
QRF-amide C201 45.50x50 ECL2 Van der Waals
QRF-amide L202 45.51x51 ECL2 Van der Waals
QRF-amide L202 45.51x51 ECL2 hydrophobic
QRF-amide E203 45.52x52 ECL2 polar (charge-assisted hydrogen bond)
QRF-amide Q211 5.35x36 TM5 Van der Waals
QRF-amide Y214 5.38x39 TM5 Van der Waals
QRF-amide Y214 5.38x39 TM5 hydrophobic
QRF-amide T215 5.39x40 TM5 Van der Waals
QRF-amide T215 5.39x40 TM5 polar (hydrogen bond with backbone)
QRF-amide T215 5.39x40 TM5 polar (hydrogen bond)
QRF-amide I218 5.42x43 TM5 Van der Waals
QRF-amide I218 5.42x43 TM5 hydrophobic
QRF-amide L222 5.46x461 TM5 Van der Waals
QRF-amide F289 6.51x51 TM6 hydrophobic
QRF-amide F289 6.51x51 TM6 Van der Waals
QRF-amide Q318 7.39x38 TM7 polar (hydrogen bond)
QRF-amide Q318 7.39x38 TM7 polar (hydrogen bond)
QRF-amide F322 7.43x42 TM7 Van der Waals
QRF-amide F322 7.43x42 TM7 hydrophobic

Ligands

QRF-amide

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Residue Diagrams

A N G F L A L A F I L V G T L V L A L K 1 C S L A L S D L L I T F F C I P V T M L Q 2 C T M T L I E T V V A T S Q V F P V M K 3 A F T M L G V V W L V A V I V G S P M W 4 Y L I L M V M L P L L F L I V L I F T T Y 5 V T V V A L F A V C W A P F H V V H M M 6 I P N C I S N S F G I I Q V I A F I M 7
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ICL1 K A M R ICL1ECL1 D N W L G G A ECL1ICL2 P F K M K W Q Y ICL2ECL2 Q L E I K Y D F L Y E K E H I C C L E E W T ECL2ICL3 H G K E ICL3ECL3 N F E K E Y D ECL3N-term M Q A L N I T P E Q F S R L L R D H N L T R E Q F I A L Y R L R P L V Y T P E L N-termC-term N K T F S P A Q R H G N S G I T M M R K K A K F S L R E N P V E E T K G E A F S D G N I E V K L C E Q T E E K K K L K R H L A L F R S E L A E N S P L D S G H C-term P G R A K L A L V L T G V L I F A L A L F G N A L V F Y V V T R S T V T N I F I C S L A L S D L L I T F F C I P V T M L Q N I S F I C K M V P F V Q S T A V V T E I L T M T C I A V E R H Q G L V H T N R R A F T M L G V V W L V A V I V G S P M W H V Q S P V H Q K I Y T T F I L V I L F L L P L M V M L I L Y S K I G Y E L W I K K R V G D G S V L R T I M S K I A R K K K R A V I M M V T V V A L F A V C W A P F H V V H M M I E Y S D V T I K M I F A I V Q I I G F S N S I C N P I V Y A F M N E N V L S C I V F K K N A V C Y
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Residue Table


GPCRdb(A)
GPCRdb(A)
QRFP receptor
TM2
2x56 2.57x56 C98
2x59 2.60x59 V101
2x60 2.61x60 T102
2x62 2.63x62 L104
2x63 2.64x63 Q105
ECL1
23x49 23.49x49 N110
23x50 23.50x50 W111
TM3
3x29 3.29x29 P122
3x32 3.32x32 Q125
3x36 3.36x36 V129
ECL2
45x50 45.50x50 C201
45x51 45.51x51 L202
45x52 45.52x52 E203
TM5
5x36 5.35x36 Q211
5x39 5.38x39 Y214
5x40 5.39x40 T215
5x43 5.42x43 I218
5x461 5.46x461 L222
TM6
6x51 6.51x51 F289
TM7
7x38 7.39x38 Q318
7x42 7.43x42 F322