QRFP receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8ZH8

RESOLUTION

3.2 Å

REFERENCE

10.1038/S41467-024-49030-5

PUBLICATION DATE

July 3, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

124 interactions (Click to see)

LIGANDS

QRF-amide - Agonist

PHYSIOLOGICAL LIGANDS

QRFP26 (26RFa), QRFP43, QRFP43 (43RFa)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 150 - G.H5 K 232 G.H5.12
Hydrophobic ICL2 P 150 - G.H5 I 235 G.H5.15
Van-der-waals ICL2 P 150 - G.H5 I 235 G.H5.15
Hydrophobic ICL2 P 150 - G.s4h3 L 236 G.s4h3.05
Van-der-waals ICL2 P 150 - G.s4h3 L 236 G.s4h3.05
Hydrophobic ICL2 F 151 - G.HN L 34 G.HN.52
Van-der-waals ICL2 F 151 - G.HN L 34 G.HN.52
Hydrophobic ICL2 F 151 - G.H5 F 228 G.H5.08
Van-der-waals ICL2 F 151 - G.H5 F 228 G.H5.08
Polar TM6 K 263 6x25 G.h4s6 D 206 G.h4s6.10
Hydrophobic TM6 K 263 6x25 G.h4s6 D 206 G.h4s6.10
Aromatic ICL2 Y 157 - G.H5 Y 243 G.H5.23
Hydrophobic ICL2 Y 157 - G.H5 Y 243 G.H5.23
Van-der-waals ICL2 Y 157 - G.H5 Y 243 G.H5.23
Polar ICL2 Y 157 - G.hns1 R 31 G.hns1.02
Hydrophobic TM2 I 84 2x43 G.H5 N 244 G.H5.24
Hydrophobic ICL2 K 154 - G.HN L 34 G.HN.52
Van-der-waals ICL2 K 154 - G.HN L 34 G.HN.52
Hydrophobic TM6 K 263 6x25 G.h4s6 G 207 G.h4s6.11
Polar ICL2 K 154 - G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 K 154 - G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 K 154 - G.hns1 R 31 G.hns1.02
Hydrophobic TM3 R 143 3x50 G.H5 L 245 G.H5.25
Van-der-waals TM3 R 143 3x50 G.H5 L 245 G.H5.25
Hydrophobic TM3 L 147 3x54 G.H5 L 245 G.H5.25
Van-der-waals TM3 L 147 3x54 G.H5 L 245 G.H5.25
Hydrophobic TM6 M 275 6x37 G.H5 L 245 G.H5.25
Van-der-waals TM6 M 275 6x37 G.H5 L 245 G.H5.25
Polar H8 N 338 8x49 G.H5 R 241 G.H5.21
Hydrophobic TM3 G 146 3x53 G.H5 Y 243 G.H5.23
Van-der-waals TM3 G 146 3x53 G.H5 Y 243 G.H5.23
Hydrophobic ICL2 F 151 - G.H5 C 231 G.H5.11
Hydrophobic TM6 I 264 6x26 G.H5 Q 237 G.H5.17
Van-der-waals TM6 I 264 6x26 G.H5 Q 237 G.H5.17
Polar ICL2 W 155 - G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 W 155 - G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 W 155 - G.hns1 R 31 G.hns1.02
Hydrophobic TM3 L 147 3x54 G.H5 L 240 G.H5.20
Van-der-waals TM3 L 147 3x54 G.H5 L 240 G.H5.20
Hydrophobic ICL2 F 151 - G.H5 I 235 G.H5.15
Aromatic ICL2 W 155 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 W 155 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 W 155 - G.hns1 R 32 G.hns1.03
Hydrophobic TM6 I 264 6x26 G.h4s6 I 210 G.h4s6.20
Van-der-waals TM6 I 264 6x26 G.h4s6 I 210 G.h4s6.20
Hydrophobic TM5 L 241 5x65 G.H5 L 240 G.H5.20
Van-der-waals TM5 L 241 5x65 G.H5 L 240 G.H5.20
Polar ICL2 M 153 - G.H5 Y 243 G.H5.23
Polar TM3 R 143 3x50 G.H5 Y 243 G.H5.23
Hydrophobic TM3 R 143 3x50 G.H5 Y 243 G.H5.23
Hydrophobic TM6 M 274 6x36 G.H5 N 244 G.H5.24
Van-der-waals TM6 M 274 6x36 G.H5 N 244 G.H5.24
Hydrophobic TM6 R 270 6x32 G.s4h3 V 246 G.s4h3.15
Van-der-waals TM6 R 270 6x32 G.s4h3 V 246 G.s4h3.15
Hydrophobic TM2 T 80 2x39 G.H5 Y 243 G.H5.23
Van-der-waals TM2 T 80 2x39 G.H5 Y 243 G.H5.23
Hydrophobic TM6 A 271 6x33 G.H5 L 240 G.H5.20
Hydrophobic TM3 L 147 3x54 G.H5 N 239 G.H5.19
Van-der-waals H8 E 337 8x48 G.s4h3 V 246 G.s4h3.15
Hydrophobic TM3 L 147 3x54 G.s4h3 L 236 G.s4h3.05
Van-der-waals TM3 L 147 3x54 G.s4h3 L 236 G.s4h3.05
Hydrophobic TM6 K 267 6x29 G.s4h3 V 246 G.s4h3.15
Hydrophobic ICL2 F 151 - G.S3 V 79 G.S3.01
Polar ICL2 W 155 - G.HN E 28 G.HN.52
Hydrophobic ICL2 W 155 - G.HN E 28 G.HN.52
Van-der-waals ICL2 W 155 - G.HN E 28 G.HN.52
Hydrophobic TM2 T 80 2x39 G.H5 N 244 G.H5.24
Van-der-waals TM2 T 80 2x39 G.H5 N 244 G.H5.24
Hydrophobic TM6 M 274 6x36 G.H5 L 245 G.H5.25
Polar H8 N 336 8x47 G.H5 N 244 G.H5.24
Hydrophobic H8 N 336 8x47 G.H5 N 244 G.H5.24
Van-der-waals H8 N 336 8x47 G.H5 N 244 G.H5.24
Hydrophobic ICL2 F 151 - G.H5 K 232 G.H5.12
Van-der-waals ICL2 F 151 - G.H5 K 232 G.H5.12