Structure information

α2A-adrenoceptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

9CBM

SPECIES

Homo sapiens

RESOLUTION

3.200

PREFERRED CHAIN

R

REFERENCE

10.1038/S12276-024-01296-X

PUBLICATION DATE

Sept. 11, 2024
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Ligand Interaction Browser

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LigandAmino AcidGeneric NumberSegmentInteraction Type
Ligand
Amino Acid
Generic Number
Segment
Interaction Type
Ligand
Amino Acid
Generic Number
Segment
Interaction Type
dexmedetomidine V129 3.33x33 TM3 hydrophobic
dexmedetomidine W402 6.48x48 TM6 aromatic (edge-to-face)
dexmedetomidine F405 6.51x51 TM6 hydrophobic
dexmedetomidine F406 6.52x52 TM6 hydrophobic
dexmedetomidine Y409 6.55x55 TM6 hydrophobic
dexmedetomidine F427 7.39x38 TM7 polar (hydrogen bond with backbone)
dexmedetomidine F427 7.39x38 TM7 Van der Waals
dexmedetomidine Y431 7.43x42 TM7 hydrophobic
dexmedetomidine Y431 7.43x42 TM7 Van der Waals
LigandAmino AcidGeneric NumberSegmentInteraction Type
Showing 1 to 9 of 9 entries

Ligands

dexmedetomidine

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Residue Diagrams

V N G F V T L L M L L G A L C V L T L T 1 V S L A S A D I L V A L T V I P F S L A N 2 A C L H V I S S T C F L V D L A L Y I E 3 I K A I I I T V W V I S A V I S F P P L 4 Y V L I M I L C P A F F S G I C S S I V Y 5 A V V I G V F V V C W F P F F F T Y T L 6 V P N L S S N C Y G F W F F F K F L T 7
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ICL1 ECL1 ICL2 ECL2 ICL3 ECL3 N-term C-term Q V T L T L V C L A G L L M L L T V F G N V L V I I A V F T S A P Q N L F L V S L A S A D I L V A T L V I P F S L A N E V M G G K A W C E I Y L A L D V L F C T S S I V H L C A I S L D R Y W S I T Q T P R R I K A I I I T V W V I S A V I S F P P L I Q K W Y V I S S C I G S F F A P C L I M I L V Y V R I Y Q I A K R R T R V P P S R R G R Q N R E K R F T F V L A V V I G V F V V C W F P F F F T Y T L T A V G P R T L F K F F F W F G Y C N S S L N P V I Y T I F N H D F K K F R R A I L C R
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Residue Table


GPCRdb(A)
GPCRdb(A)
α2A-adrenoceptor
TM3
3x33 3.33x33 V129
TM6
6x48 6.48x48 W402
6x51 6.51x51 F405
6x52 6.52x52 F406
6x55 6.55x55 Y409
TM7
7x38 7.39x38 F427
7x42 7.43x42 Y431