GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.2 Å

REFERENCE

PUBLICATION DATE

Sept. 11, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

dexmedetomidine - Agonist pubchem gtoplig chembl_ligand drugbank drug_central

PHYSIOLOGICAL LIGANDS

(-)-noradrenaline, (-)-adrenaline



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic ICL2 I 154 34x51 G.H5 I 343 G.H5.15
Hydrophobic ICL2 N 157 34x54 G.H5 I 343 G.H5.15
Hydrophobic ICL3 R 241 - G.H5 I 344 G.H5.16
Polar TM6 F 387 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 F 387 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 F 387 6x33 G.H5 L 353 G.H5.25
Polar TM3 S 149 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 S 149 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 S 149 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL3 T 242 - G.H5 K 345 G.H5.17
Van-der-waals TM6 R 383 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM5 I 234 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 I 234 5x61 G.H5 L 353 G.H5.25
Hydrophobic ICL2 A 153 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM3 I 150 3x54 G.H5 I 344 G.H5.16
Polar ICL3 R 241 - G.H5 K 345 G.H5.17
Hydrophobic ICL3 R 241 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 R 241 - G.H5 K 345 G.H5.17
Hydrophobic TM3 I 150 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM3 I 150 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 150 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 I 154 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM5 A 238 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM6 L 391 6x37 G.H5 L 353 G.H5.25
Hydrophobic ICL3 T 242 - G.H5 F 354 G.H5.26
Hydrophobic TM6 V 390 6x36 G.H5 L 353 G.H5.25
Polar ICL2 N 157 34x54 G.H5 N 347 G.H5.19
Hydrophobic TM6 R 386 6x32 G.H5 L 353 G.H5.25
Van-der-waals TM6 R 386 6x32 G.H5 L 353 G.H5.25
Hydrophobic TM6 R 386 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 386 6x32 G.H5 F 354 G.H5.26
Hydrophobic ICL2 I 154 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 I 154 34x51 G.H5 F 336 G.H5.08
Polar TM6 R 386 6x32 G.H5 G 352 G.H5.24
Hydrophobic TM6 R 386 6x32 G.H5 G 352 G.H5.24
Van-der-waals TM6 R 386 6x32 G.H5 G 352 G.H5.24
Hydrophobic TM5 I 234 5x61 G.H5 L 348 G.H5.20
Hydrophobic ICL2 A 153 34x50 G.H5 I 343 G.H5.15
Polar H8 N 445 8x47 G.H5 D 350 G.H5.22
Hydrophobic H8 N 445 8x47 G.H5 D 350 G.H5.22
Van-der-waals H8 N 445 8x47 G.H5 D 350 G.H5.22
Hydrophobic TM3 R 146 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM6 V 390 6x36 G.H5 G 352 G.H5.24