Structure information

TAS2R14

PROTEIN CLASS

Class T2 (Taste 2)

PDB CODE

9IJA

SPECIES

Homo sapiens

RESOLUTION

3.050

PREFERRED CHAIN

R

REFERENCE

PUBLICATION DATE

July 24, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
compound 28.1 [PMID: 36847646] Y107 3.50x50 TM3 hydrophobic
compound 28.1 [PMID: 36847646] S194 5.54x54 TM5 polar (hydrogen bond)
compound 28.1 [PMID: 36847646] S194 5.54x54 TM5 Van der Waals
compound 28.1 [PMID: 36847646] M197 5.57x57 TM5 hydrophobic
compound 28.1 [PMID: 36847646] M197 5.57x57 TM5 Van der Waals
compound 28.1 [PMID: 36847646] F198 5.58x58 TM5 Van der Waals
compound 28.1 [PMID: 36847646] F198 5.58x58 TM5 aromatic (edge-to-face)
compound 28.1 [PMID: 36847646] L201 5.61x61 TM5 hydrophobic
compound 28.1 [PMID: 36847646] L201 5.61x61 TM5 Van der Waals
compound 28.1 [PMID: 36847646] S232 6.37x37 TM6 polar (hydrogen bond)
compound 28.1 [PMID: 36847646] V233 6.38x38 TM6 Van der Waals
compound 28.1 [PMID: 36847646] F236 6.41x41 TM6 aromatic (edge-to-face)
compound 28.1 [PMID: 36847646] F236 6.41x41 TM6 Van der Waals
compound 28.1 [PMID: 36847646] Y240 6.45x45 TM6 polar (hydrogen bond)
compound 28.1 [PMID: 36847646] Y240 6.45x45 TM6 Van der Waals
compound 28.1 [PMID: 36847646] H276 7.49x49 TM7 Van der Waals

Ligands

compound 28.1 [PMID: 36847646]

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Residue Diagrams

S N G L N G I I F E V I L V F T F I S K 1 T A L A I S R I S L V W L I F G S W C V 2 G T A L W V S F H N I V T W I N T L M R 3 V L V L L L V T S V F L F L N I A L I N 4 F M A L S L T F P I F I F V T S T L V I 5 V I T F F L L Y A I F S L S F F I S V W 6 C S H C S P Y A M G M V Q S L I I L N 7
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ICL1 R K I ICL1ECL1 P A L F A ECL1ICL2 N F S N S I F L Y L K W ICL2ECL2 A S I N G Y R R N K T C S S D S S N F T R F S S L ECL2ICL3 K I S G D A S T K A ICL3ECL3 E E ECL3C-term G E P S G H K E F R E S S C-term M G G V I K S I F T F V L I V E F I I G N L G N S F I A L V N C I D W V K G S S V D R I L T A L A I S R I S L V W L I F G S W C V S V F F T E K M F R M L T N I W T V I N H F S V W L A T G L G T F Y F L K I A R V K K V V L V L L L V T S V F L F L N I A L I N I H I N I V L T S T V F I F I P F T L S L A M F L L L I F S M W K H R K K M Q H T V H R G V K S V I T F F L L Y A I F S L S F F I S V W T S E R L N L I I L S Q V M G M A Y P S C H S C V L I L G N K K S L S L R Y L R Q A V L L W M F K D
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Residue Table


GPCRdb(A)
GPCRdb(A)
TAS2R14
TM3
3x50 3.50x50 Y107
TM5
5x54 5.54x54 S194
5x57 5.57x57 M197
5x58 5.58x58 F198
5x61 5.61x61 L201
TM6
6x37 6.37x37 S232
6x38 6.38x38 V233
6x41 6.41x41 F236
6x45 6.45x45 Y240
TM7
7x49 7.49x49 H276