PDB
9KUV
Resolution
3.2 Å
Released
Sept. 17, 2025
Receptor
apelin
Class
A
Species
Homo sapiens
Ligand
Function
cmpd644
Agonist
Reference
—

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file
Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
cmpd644 F78 2.53x53 TM2 hydrophobic
cmpd644 W85 2.60x60 TM2 hydrophobic
cmpd644 W85 2.60x60 TM2 aromatic (edge-to-face)
cmpd644 S106 3.29x29 TM3 Van der Waals
cmpd644 I109 3.32x32 TM3 hydrophobic
cmpd644 F110 3.33x33 TM3 Van der Waals
cmpd644 M113 3.36x36 TM3 hydrophobic
cmpd644 R168 4.64x65 TM4 polar (charge-charge)
cmpd644 W261 6.48x48 TM6 Van der Waals
cmpd644 Y264 6.51x51 TM6 polar (hydrogen bond)
cmpd644 Y264 6.51x51 TM6 hydrophobic
cmpd644 V267 6.54x54 TM6 Van der Waals
cmpd644 Y271 6.58x58 TM6 aromatic (edge-to-face)
cmpd644 Y271 6.58x58 TM6 hydrophobic
cmpd644 L287 7.31x30 TM7 hydrophobic
cmpd644 M288 7.32x31 TM7 Van der Waals
cmpd644 F291 7.35x34 TM7 aromatic (edge-to-face)
cmpd644 F291 7.35x34 TM7 hydrophobic
cmpd644 T295 7.39x38 TM7 hydrophobic
cmpd644 Y299 7.43x42 TM7 Van der Waals

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 S R E K R ICL1ECL1 Y D W P F ECL1ICL2 P V A N A R L R ICL2ECL2 T T G D L E N T T K V Q C Y M D Y S M V A T V S ECL2ICL3 R K E ICL3ECL3 L H W ECL3N-term M E E G G D F D N Y Y G A D N Q S E C E Y T D W K S S G N-termC-term Q S R C A G T S H S S S G E K S A S Y S S G H S Q G P G P N M G K G G E Q M H E K S I P Y S Q E T L V V D C-term A L I P A I Y M L V F L L G T T G N G L V L W T V F R S R S A D I F I A S L A V A D L T F V V T L P L W A T Y T Y R D G T F F C K L S S Y L I F V N M Y A S V F C L T G L S F D R Y L A I V R L R V S G A V A T A V L W V L A A L L A M P V M V L R S E W A W E V G L G V S S T T V G F V V P F T I M L T C Y F F I A Q T I A G H F R I E G L R K R R R L L S I I V V L V V T F A L C W M P Y H L V K T L Y M L G S L P C D F D L F L M N I F P Y C T C I S Y V N S C L N P F L Y A F F D P R C T S G F R Q A M L C C
Helix box plot — Download: PNG | SVG G N G T T G L L F V L M Y I A P I L A 1 A S L A V A D L T F V V T L P L W A T Y 2 G T L C F V S A Y M N V F I L Y S S L K 3 G A V A T A V L W V L A A L L A M P V 4 Y C T L M I T F P V V F G V T T S S V G L 5 V V L V V T F A L C W M P Y H L V K T L 6 F P N L C S N V Y S I C T C Y P F I N 7

GPCRdb(A)
GPCRdb(A)
apelin receptor
TM2
2x53 2.53x53 F78
2x60 2.60x60 W85
TM3
3x29 3.29x29 S106
3x32 3.32x32 I109
3x33 3.33x33 F110
3x36 3.36x36 M113
TM4
4x65 4.64x65 R168
TM6
6x48 6.48x48 W261
6x51 6.51x51 Y264
6x54 6.54x54 V267
6x58 6.58x58 Y271
TM7
7x30 7.31x30 L287
7x31 7.32x31 M288
7x34 7.35x34 F291
7x38 7.39x38 T295
7x42 7.43x42 Y299