apelin receptor - Beta-arrestin-1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

ARRESTIN (FAMILY)

Beta

ARRESTIN

Beta-arrestin-1

ARRESTIN SPECIES

Human

ARRESTIN CHAIN

A

ARRESTIN COVERAGE

139

PDB CODE

9KUV

RESOLUTION

3.2 Å

REFERENCE

PUBLICATION DATE

Sept. 17, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

41 interactions (Click to see)

LIGANDS

cmpd644 - Agonist pubchem

PHYSIOLOGICAL LIGANDS

apelin receptor early endogenous ligand (Mouse), apelin receptor early endogenous ligand (Human), apelin-13 (Human), apelin-17 (Human), Elabela/Toddler-11 (Human), Elabela/Toddler-21 (Human), apelin-36 (Mouse), [Pyr1]apelin-13 (Human), apelin-36 (Human), Elabela/Toddler-32 (Human)



GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM5 F 232 5x69 s5s6 L 73 N.s5s6.10
Hydrophobic TM6 L 246 6x33 s5s6 G 72 N.s5s6.09
Hydrophobic C-term K 359 - H1 R 103 N.H1.05
Polar C-term L 357 - ns1 T 6 N.ns1.14
Hydrophobic C-term L 357 - ns1 T 6 N.ns1.14
Van-der-waals C-term L 357 - ns1 T 6 N.ns1.14
Polar ICL2 V 135 34x51 S5 Y 63 N.S5.12
Hydrophobic ICL2 V 135 34x51 S5 Y 63 N.S5.12
Hydrophobic C-term L 357 - H1 L 100 N.H1.02
Van-der-waals C-term L 357 - H1 L 100 N.H1.02
Hydrophobic ICL2 R 141 34x57 s17s18 R 285 C.s17s18.11
Hydrophobic TM7 F 312 7x56 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 F 312 7x56 s5s6 V 70 N.s5s6.07
Hydrophobic C-term L 357 - S1 V 8 N.S1.01
Van-der-waals C-term L 357 - S1 V 8 N.S1.01
Hydrophobic TM3 I 131 3x54 S6 F 75 N.S6.01
Van-der-waals TM3 R 133 3x56 s15s16 N 245 C.s15s16.04
Hydrophobic TM5 H 231 5x68 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 H 231 5x68 s5s6 L 73 N.s5s6.10
Hydrophobic H8 P 314 8x48 s5s6 L 71 N.s5s6.08
Polar TM5 H 231 5x68 s5s6 T 74 N.s5s6.11
Hydrophobic TM5 H 231 5x68 s5s6 T 74 N.s5s6.11
Van-der-waals TM5 H 231 5x68 s5s6 T 74 N.s5s6.11
Hydrophobic ICL2 P 134 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 P 134 34x50 S5 Y 63 N.S5.12
Ionic TM4 R 143 4x39 s8s9 E 134 N.s8s9.05
Polar TM4 R 143 4x39 s8s9 E 134 N.s8s9.05
Hydrophobic TM4 R 143 4x39 s8s9 E 134 N.s8s9.05
Van-der-waals TM4 R 143 4x39 s8s9 E 134 N.s8s9.05
Hydrophobic ICL2 P 134 34x50 S6 F 75 N.S6.01
Hydrophobic TM3 I 131 3x54 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 I 131 3x54 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 I 131 3x54 s5s6 L 73 N.s5s6.10
Van-der-waals TM3 I 131 3x54 s5s6 L 73 N.s5s6.10
Polar TM6 R 245 6x32 s5s6 V 70 N.s5s6.07
Van-der-waals TM6 R 245 6x32 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 R 127 3x50 s5s6 V 70 N.s5s6.07
Polar C-term A 353 - S1 K 10 N.S1.03
Hydrophobic C-term A 353 - S1 K 10 N.S1.03
Van-der-waals C-term A 353 - S1 K 10 N.S1.03
Hydrophobic C-term L 357 - H1 L 104 N.H1.06
Hydrophobic TM6 L 246 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic TM5 F 232 5x69 s5s6 G 72 N.s5s6.09
Van-der-waals TM5 F 232 5x69 s5s6 G 72 N.s5s6.09
Hydrophobic TM5 I 228 5x65 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 I 228 5x65 s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 A 138 34x54 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 A 138 34x54 s5s6 R 65 N.s5s6.02
Polar ICL2 R 139 34x55 s17s18 R 285 C.s17s18.11
Hydrophobic ICL2 R 139 34x55 s17s18 R 285 C.s17s18.11
Van-der-waals ICL2 R 139 34x55 s17s18 R 285 C.s17s18.11
Polar C-term L 357 - H1 R 103 N.H1.05
Hydrophobic C-term L 357 - H1 R 103 N.H1.05
Van-der-waals C-term L 357 - H1 R 103 N.H1.05
Hydrophobic ICL2 R 139 34x55 s17s18 G 286 C.s17s18.12
Van-der-waals ICL2 R 139 34x55 s17s18 G 286 C.s17s18.12
Polar ICL2 A 136 34x52 S16 Y 249 C.S16.03
Hydrophobic ICL2 A 136 34x52 S16 Y 249 C.S16.03
Van-der-waals ICL2 A 136 34x52 S16 Y 249 C.S16.03
Hydrophobic TM3 A 130 3x53 S6 F 75 N.S6.01
Van-der-waals TM3 A 130 3x53 S6 F 75 N.S6.01
Hydrophobic ICL2 V 135 34x51 S9 I 140 N.S9.01
Hydrophobic C-term L 357 - H1 K 107 N.H1.09
Hydrophobic ICL2 L 140 34x56 s17s18 R 285 C.s17s18.11
Hydrophobic ICL2 V 135 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 V 135 34x51 S15 I 241 C.S15.14
Polar TM6 R 245 6x32 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 R 245 6x32 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 R 245 6x32 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 R 139 34x55 S16 Y 249 C.S16.03
Van-der-waals ICL2 R 139 34x55 S16 Y 249 C.S16.03
Hydrophobic TM6 L 246 6x33 s5s6 V 70 N.s5s6.07
Van-der-waals TM6 L 246 6x33 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 P 134 34x50 s5s6 G 64 N.s5s6.01
Polar C-term A 358 - H1 R 103 N.H1.05
Hydrophobic TM7 F 312 7x56 s5s6 L 71 N.s5s6.08
Van-der-waals TM7 F 312 7x56 s5s6 L 71 N.s5s6.08
Polar ICL2 V 135 34x51 S16 Y 249 C.S16.03
Hydrophobic ICL2 V 135 34x51 S16 Y 249 C.S16.03
Van-der-waals ICL2 V 135 34x51 S16 Y 249 C.S16.03