PDB
9L80
Resolution
3.3 Å
Released
Dec. 31, 2025
Receptor
GPR119
Class
A
Species
Homo sapiens
Ligand
Function
ATAZANAVIR
Ago-PAM
Reference
10.1016/J.CELL.2025.12.023

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Ligand Amino Acid Generic Number Segment Interaction Type
ATAZANAVIR R225 6.35x35 TM6 Van der Waals
ATAZANAVIR S228 6.38x38 TM6 Van der Waals
ATAZANAVIR V229 6.39x39 TM6 hydrophobic
ATAZANAVIR G232 6.42x42 TM6 Van der Waals
ATAZANAVIR L274 7.48x48 TM7 Van der Waals
ATAZANAVIR I278 7.52x52 TM7 hydrophobic
ATAZANAVIR W282 7.56x56 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 I H K N D ICL1ECL1 S P S ECL1ICL2 P F R Y L K I M ICL2ECL2 P M F Q Q T A Y K G Q C S F F A V ECL2ICL3 A M A G G Y ICL3ECL3 Q E C H L ECL3C-term G V K K V L T S F L L F L S A R N C G P E R P R E S S C H I V T I S S S E F D G C-term M E S S F S F G V I L A V L A S L I I A T N T L V A V A V L L L G V S L C F T L N L A V A D T L I G V A I S G L L T D Q L S R P T Q K T L C S L R M A F V T S S A A A S V L T V M L I T F D R Y L A I K Q S G F V A G A C I A G L W L V S Y L I G F L P L G I F H P H F V L T L S C V G F F P A M L L F V F F Y C D M L K I A S M H S Q Q I R K M E H A G R S P R T P S D F K A L R T V S V L I G S F A L S W T P F L I T G I V Q V A C Y L V L E R Y L W L L G V G N S L L N P L I Y A Y W Q K E L Y H V R L Q M A L
Helix box plot — Download: PNG | SVG T N T A I I L S A L V A L I V G F S F S 1 L N L A V A D T L I G V A I S G L L T D 2 L M V T L V S A A A S S T V F A M R L S 3 A G A C I A G L W L V S Y L I G F L P L 4 F F V F L L M A P F F G V C S L T L V F H 5 S V L I G S F A L S W T P F L I T G I V 6 L P N L L S N G V G L L W L Y R E L V 7

GPCRdb(A)
GPCRdb(A)
GPR119
TM6
6x35 6.35x35 R225
6x38 6.38x38 S228
6x39 6.39x39 V229
6x42 6.42x42 G232
TM7
7x48 7.48x48 L274
7x52 7.52x52 I278
7x56 7.56x56 W282