GPR119 - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9L80

RESOLUTION

3.3 Å

REFERENCE

10.1016/J.CELL.2025.12.023

PUBLICATION DATE

Dec. 31, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

13 interactions (Click to see)

LIGANDS

ATAZANAVIR - Ago-PAM chembl_ligand pubchem drugbank

PHYSIOLOGICAL LIGANDS

SEA, N-palmitoylethanolamine, N-oleoylethanolamide, anandamide



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 F 111 34x51 G.H5 I 373 G.H5.15
Van-der-waals ICL2 F 111 34x51 G.H5 I 373 G.H5.15
Hydrophobic TM6 V 227 6x37 G.H5 L 383 G.H5.25
Aromatic ICL2 F 111 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 111 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 111 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 K 115 34x55 G.hns1 A 39 G.hns1.03
Aromatic TM5 H 195 5x69 G.H5 R 375 G.H5.17
Hydrophobic TM5 H 195 5x69 G.H5 R 375 G.H5.17
Hydrophobic ICL2 F 111 34x51 G.H5 C 369 G.H5.11
Hydrophobic ICL2 L 114 34x54 G.S1 H 41 G.S1.02
Hydrophobic ICL2 P 110 34x50 G.H5 I 373 G.H5.15
Hydrophobic TM5 S 196 5x70 G.H5 L 384 G.H5.26
Polar ICL2 K 115 34x55 G.s2s3 K 216 G.s2s3.02
Polar ICL2 M 117 34x57 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 M 117 34x57 G.hns1 R 38 G.hns1.02
Hydrophobic TM5 A 205 5x79 G.H4 L 336 G.H4.16
Polar ICL2 L 114 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 L 114 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 L 114 34x54 G.hns1 R 38 G.hns1.02
Ionic TM5 H 195 5x69 G.H5 D 371 G.H5.13
Polar TM5 H 195 5x69 G.H5 D 371 G.H5.13
Polar ICL3 A 209 - G.H4 R 337 G.H4.17
Hydrophobic ICL3 A 209 - G.H4 R 337 G.H4.17
Van-der-waals ICL3 A 209 - G.H4 R 337 G.H4.17
Hydrophobic TM3 I 107 3x54 G.H5 H 377 G.H5.19
Hydrophobic ICL2 P 110 34x50 G.H5 R 370 G.H5.12
Hydrophobic ICL3 G 206 - G.H4 R 337 G.H4.17
Polar TM3 I 107 3x54 G.H5 Q 374 G.H5.16
Van-der-waals TM3 I 107 3x54 G.H5 Q 374 G.H5.16
Aromatic TM3 R 103 3x50 G.H5 Y 381 G.H5.23
Hydrophobic TM3 R 103 3x50 G.H5 Y 381 G.H5.23
Hydrophobic ICL2 F 111 34x51 G.H5 R 370 G.H5.12
Hydrophobic TM3 I 107 3x54 G.H5 Y 381 G.H5.23
Hydrophobic ICL2 P 110 34x50 G.H5 Q 374 G.H5.16
Hydrophobic TM6 A 223 6x33 G.H5 L 383 G.H5.25
Van-der-waals TM6 A 223 6x33 G.H5 L 383 G.H5.25
Hydrophobic TM5 I 199 5x73 G.H5 R 375 G.H5.17
Hydrophobic TM4 S 118 4x38 G.HN Q 35 G.HN.52
Van-der-waals TM4 S 118 4x38 G.HN Q 35 G.HN.52
Polar TM6 T 226 6x36 G.H5 E 382 G.H5.24
Polar TM6 S 219 6x29 G.H5 L 384 G.H5.26
Van-der-waals TM6 S 219 6x29 G.H5 L 384 G.H5.26
Hydrophobic TM5 M 202 5x76 G.H4 L 336 G.H4.16
Hydrophobic TM5 L 189 5x63 G.H5 L 383 G.H5.25
Hydrophobic TM3 A 106 3x53 G.H5 H 377 G.H5.19
Van-der-waals TM3 A 106 3x53 G.H5 H 377 G.H5.19
Hydrophobic TM5 H 195 5x69 G.H5 Q 374 G.H5.16
Hydrophobic TM5 A 192 5x66 G.H5 L 378 G.H5.20
Hydrophobic TM7 W 282 7x56 G.H5 E 382 G.H5.24
Hydrophobic TM5 I 199 5x73 G.h4s6 Y 348 G.h4s6.20
Hydrophobic TM5 K 201 5x75 G.hgh4 D 313 G.hgh4.13
Van-der-waals TM5 K 201 5x75 G.hgh4 D 313 G.hgh4.13
Hydrophobic TM5 M 188 5x62 G.H5 L 383 G.H5.25
Van-der-waals TM5 M 188 5x62 G.H5 L 383 G.H5.25
Van-der-waals ICL3 G 206 - G.h4s6 T 340 G.h4s6.03
Aromatic ICL2 F 111 34x51 G.H5 F 366 G.H5.08
Hydrophobic ICL2 F 111 34x51 G.H5 F 366 G.H5.08
Van-der-waals ICL2 F 111 34x51 G.H5 F 366 G.H5.08