PDB
9LXR
Resolution
3.1 Å
Released
Sept. 10, 2025
Receptor
PTH1
Class
B1
Species
Homo sapiens
Ligand
Function
Long-acting parathyroid hormone analog
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
Long-acting parathyroid hormone analog V31 N-term Van der Waals
Long-acting parathyroid hormone analog M32 N-term polar (hydrogen bond with backbone)
Long-acting parathyroid hormone analog T33 N-term Van der Waals
Long-acting parathyroid hormone analog K34 N-term Van der Waals
Long-acting parathyroid hormone analog E35 N-term polar (charge-charge)
Long-acting parathyroid hormone analog I38 N-term hydrophobic
Long-acting parathyroid hormone analog L41 N-term hydrophobic
Long-acting parathyroid hormone analog D137 N-term polar (charge-charge)
Long-acting parathyroid hormone analog Y167 N-term Van der Waals
Long-acting parathyroid hormone analog C170 N-term Van der Waals
Long-acting parathyroid hormone analog E177 1.29x29 TM1 polar (hydrogen bond with backbone)
Long-acting parathyroid hormone analog E180 1.32x32 TM1 Van der Waals
Long-acting parathyroid hormone analog R181 1.33x33 TM1 hydrophobic
Long-acting parathyroid hormone analog F184 1.36x36 TM1 hydrophobic
Long-acting parathyroid hormone analog F184 1.36x36 TM1 polar (hydrogen bond with backbone)
Long-acting parathyroid hormone analog F184 1.36x36 TM1 aromatic (edge-to-face)
Long-acting parathyroid hormone analog D185 1.37x37 TM1 polar (charge-charge)
Long-acting parathyroid hormone analog L187 1.39x39 TM1 hydrophobic
Long-acting parathyroid hormone analog Y195 1.47x47 TM1 Van der Waals
Long-acting parathyroid hormone analog L244 2.71x71 TM2 hydrophobic
Long-acting parathyroid hormone analog Y245 2.72x72 TM2 hydrophobic
Long-acting parathyroid hormone analog Y245 2.72x72 TM2 aromatic (pi-cation)
Long-acting parathyroid hormone analog V285 3.33x33 TM3 Van der Waals
Long-acting parathyroid hormone analog F288 3.36x36 TM3 hydrophobic
Long-acting parathyroid hormone analog L289 3.37x37 TM3 hydrophobic
Long-acting parathyroid hormone analog L292 3.40x40 TM3 hydrophobic
Long-acting parathyroid hormone analog Y296 3.44x44 TM3 Van der Waals
Long-acting parathyroid hormone analog D353 45.52x52 ECL2 hydrophobic
Long-acting parathyroid hormone analog D353 45.52x52 ECL2 polar (hydrogen bond with backbone)
Long-acting parathyroid hormone analog L354 ECL2 hydrophobic
Long-acting parathyroid hormone analog S355 ECL2 Van der Waals
Long-acting parathyroid hormone analog K360 5.36x37 TM5 Van der Waals
Long-acting parathyroid hormone analog W361 5.37x38 TM5 Van der Waals
Long-acting parathyroid hormone analog Q364 5.40x40 TM5 hydrophobic
Long-acting parathyroid hormone analog F424 ECL3 Van der Waals
Long-acting parathyroid hormone analog T427 ECL3 polar (hydrogen bond with backbone)
Long-acting parathyroid hormone analog Y429 ECL3 hydrophobic
Long-acting parathyroid hormone analog T430 ECL3 polar (hydrogen bond with backbone)
Long-acting parathyroid hormone analog V432 ECL3 hydrophobic
Long-acting parathyroid hormone analog W437 7.35x34 TM7 hydrophobic
Long-acting parathyroid hormone analog Q440 7.38x37 TM7 Van der Waals
Long-acting parathyroid hormone analog M441 7.39x38 TM7 hydrophobic
Long-acting parathyroid hormone analog E444 7.42x41 TM7 hydrophobic
Long-acting parathyroid hormone analog M445 7.43x42 TM7 hydrophobic
Long-acting parathyroid hormone analog N448 7.46x45 TM7 Van der Waals

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ICL1 R R L H ICL1ECL1 L D E A E R L T E E E L R A I A Q A P P P P A T A A A ECL1ICL2 A F F ICL2ECL2 N T G C W D L S S ECL2ICL3 R E T N A G R C ICL3ECL3 P Y T E V S ECL3N-term M G T A R I A P G L A L L L C C P V L S S A Y A L V D A D D V M T K E E Q I F L L H R A Q A Q C E K R L K E V L Q R P A S I M E S D K G W T S A S T S G K P R K D K A S G K L Y P E S E E D K E A P T G S R Y R G R P C L P E W D H I L C W P L G A P G E V V A V P C P D Y I Y D F N H K G H A Y R R C D R N G S W E L V P G H N R T W A N Y S E C V K N-termC-term S G S S S Y S Y G P M V S H T S V T N V G P R V G L G L P L S P R L L P T A T T N G H P Q L P G H A K P G T P A L E T L E T T P P A M A A P K D D G F L N G S C S G L D E E A S G P E R P P A L L Q E E W E T V M C-term F L T N E T R E R E V F D R L G M I Y T V G Y S V S L A S L T V A V L I L A Y F C T R N Y I H M H L F L S F M L R A V S I F V K D A V L Y S G A T G Y A G C R V A V T F F L Y F L A T N Y Y W I L V E G L Y L H S L I F M S E K K Y L W G F T V F G W G L P A V F V A V W V S V R A T L A G N K K W I I Q V P I L A S I V L N F I L F I N I V R V L A T K L D T R Q Q Y R K L L K S T L V L M P L F G V H Y I V F M A T G T L W Q V Q M H Y E M L F N S F Q G F F V A I I Y C F C N G E I K K W T L K R K V Q A E S W S R A L D F A R
Helix box plot — Download: PNG | SVG T L S A L S V S Y G V T Y I M G L R D F 1 M H L F L S F M L R A V S I F V K D A V 2 V L I W Y Y N T A L F Y L F F T V A V R 3 Y L W G F T V G F W G L P A V F V A V W V 4 F L I F N L V I S A L I P V Q I I W K K N 5 L V L M P L F G V H Y I V F M A T 6 I A V F F G Q F S N F L M E Y H M Q V 7

GPCRdb(A)
GPCRdb(B)
PTH1 receptor
TM1
1x25 1.29x29 E177
1x28 1.32x32 E180
1x29 1.33x33 R181
1x32 1.36x36 F184
1x33 1.37x37 D185
1x35 1.39x39 L187
1x43 1.47x47 Y195
TM2
2x64 2.71x71 L244
2x65 2.72x72 Y245
TM3
3x29 3.33x33 V285
3x32 3.36x36 F288
3x33 3.37x37 L289
3x36 3.40x40 L292
3x40 3.44x44 Y296
ECL2
45x52 45.52x52 D353
TM5
5x41 5.36x37 K360
5x42 5.37x38 W361
5x44 5.40x40 Q364
TM7
7x30 7.35x34 W437
7x33 7.38x37 Q440
7x34 7.39x38 M441
7x37 7.42x41 E444
7x38 7.43x42 M445
7x41 7.46x45 N448