PTH1 receptor - Beta-arrestin-1

GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

ARRESTIN (FAMILY)

Beta

ARRESTIN

Beta-arrestin-1

ARRESTIN SPECIES

Human

ARRESTIN CHAIN

B

ARRESTIN COVERAGE

83

PDB CODE

9LXR

RESOLUTION

3.1 Å

REFERENCE

PUBLICATION DATE

Sept. 10, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

98 interactions (Click to see)

LIGANDS

Long-acting parathyroid hormone analog - Agonist pubchem

PHYSIOLOGICAL LIGANDS

PTHrP-(1-36) (Human), PTHrP (Human), TIP39 (Human), PTH (Human), PTH (Mouse), PTH (Rat)



GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM3 I 310 3x58 S5 Y 63 N.S5.12
Hydrophobic TM6 K 405 6x37 s5s6 L 73 N.s5s6.10
Hydrophobic C-term N 507 - ns1 T 6 N.ns1.14
Van-der-waals C-term N 507 - ns1 T 6 N.ns1.14
Hydrophobic TM3 I 310 3x58 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 I 310 3x58 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 L 309 3x57 s5s6 L 68 N.s5s6.05
Hydrophobic TM5 L 389 5x65 s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 F 314 - S16 A 247 C.S16.01
Van-der-waals ICL2 F 314 - S16 A 247 C.S16.01
Hydrophobic TM6 V 412 6x44 s5s6 V 70 N.s5s6.07
Hydrophobic H8 A 468 8x52 s8s9 E 134 N.s8s9.05
Hydrophobic C-term V 500 - s9s10 K 160 N.s9s10.12
Ionic TM2 R 219 2x46 s5s6 D 67 N.s5s6.04
Hydrophobic TM2 R 219 2x46 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 R 219 2x46 s5s6 D 67 N.s5s6.04
Hydrophobic TM5 K 388 5x64 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 K 388 5x64 s5s6 L 73 N.s5s6.10
Hydrophobic TM5 L 385 5x61 s5s6 L 71 N.s5s6.08
Van-der-waals TM5 L 385 5x61 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 L 413 6x45 s5s6 V 70 N.s5s6.07
Hydrophobic TM5 I 381 5x57 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 S 316 - S16 Y 249 C.S16.03
Hydrophobic C-term V 505 - ns1 T 6 N.ns1.14
Hydrophobic TM6 S 409 6x41 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 F 314 - s15s16 L 243 C.s15s16.02
Hydrophobic ICL2 F 314 - S5 Y 63 N.S5.12
Van-der-waals ICL2 F 314 - S5 Y 63 N.S5.12
Polar TM6 K 405 6x37 s5s6 G 72 N.s5s6.09
Van-der-waals TM6 K 405 6x37 s5s6 G 72 N.s5s6.09
Polar ICL2 F 315 - S16 Y 249 C.S16.03
Hydrophobic ICL2 F 315 - S16 Y 249 C.S16.03
Van-der-waals ICL2 F 315 - S16 Y 249 C.S16.03
Polar TM5 K 388 5x64 s5s6 T 74 N.s5s6.11
Hydrophobic TM5 K 388 5x64 s5s6 T 74 N.s5s6.11
Van-der-waals TM5 K 388 5x64 s5s6 T 74 N.s5s6.11
Hydrophobic ICL2 F 314 - S8 L 129 N.S8.03
Hydrophobic H8 G 464 8x48 s8s9 E 134 N.s8s9.05
Hydrophobic C-term V 505 - S1 F 9 N.S1.02
Hydrophobic C-term V 505 - S1 V 8 N.S1.01
Van-der-waals C-term V 505 - S1 V 8 N.S1.01
Hydrophobic TM3 L 306 3x54 s5s6 L 68 N.s5s6.05
Ionic H8 E 465 8x49 s17s18 R 285 C.s17s18.11
Polar H8 E 465 8x49 s17s18 R 285 C.s17s18.11
Van-der-waals H8 E 465 8x49 s17s18 R 285 C.s17s18.11
Ionic TM2 R 219 2x46 s5s6 D 69 N.s5s6.06
Hydrophobic TM3 I 310 3x58 S6 F 75 N.S6.01
Hydrophobic TM6 L 413 6x45 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 L 413 6x45 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 L 309 3x57 s5s6 D 67 N.s5s6.04
Polar C-term H 502 - s17s18 K 294 C.s17s18.20
Hydrophobic TM7 Y 459 7x57 s5s6 V 70 N.s5s6.07
Hydrophobic C-term V 505 - ns1 R 7 N.ns1.15
Hydrophobic H8 E 465 8x49 s8s9 E 134 N.s8s9.05
Van-der-waals H8 E 465 8x49 s8s9 E 134 N.s8s9.05
Polar C-term N 507 - H1 K 107 N.H1.09
Hydrophobic C-term N 507 - H1 K 107 N.H1.09
Van-der-waals C-term N 507 - H1 K 107 N.H1.09
Hydrophobic ICL2 A 313 - S5 Y 63 N.S5.12
Van-der-waals ICL2 A 313 - S5 Y 63 N.S5.12
Hydrophobic ICL2 F 314 - S16 Y 249 C.S16.03
Van-der-waals ICL2 F 314 - S16 Y 249 C.S16.03
Hydrophobic ICL1 R 214 12x49 s17s18 E 283 C.s17s18.09
Van-der-waals ICL1 R 214 12x49 s17s18 E 283 C.s17s18.09
Aromatic TM5 K 388 5x64 S6 F 75 N.S6.01
Van-der-waals TM5 K 388 5x64 S6 F 75 N.S6.01
Hydrophobic ICL1 R 214 12x49 s8s9 P 133 N.s8s9.04
Hydrophobic TM3 I 310 3x58 s5s6 L 68 N.s5s6.05
Hydrophobic ICL2 F 314 - S9 C 140 N.S9.01
Hydrophobic C-term N 507 - S1 V 8 N.S1.01
Hydrophobic TM5 L 385 5x61 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 L 385 5x61 s5s6 L 73 N.s5s6.10
Hydrophobic H8 E 465 8x49 s8s9 P 133 N.s8s9.04
Van-der-waals H8 E 465 8x49 s8s9 P 133 N.s8s9.04
Hydrophobic ICL2 F 314 - S15 I 241 C.S15.14
Van-der-waals ICL2 F 314 - S15 I 241 C.S15.14
Hydrophobic ICL2 F 315 - S16 A 247 C.S16.01
Aromatic ICL2 F 314 - S5 F 61 N.S5.10
Hydrophobic ICL2 F 314 - S5 F 61 N.S5.10
Van-der-waals ICL2 F 314 - S5 F 61 N.S5.10
Polar ICL1 R 214 12x49 s17s18 R 285 C.s17s18.11
Van-der-waals ICL1 R 214 12x49 s17s18 R 285 C.s17s18.11