PDB
9PU5
Resolution
3.5 Å
Released
May 27, 2026
Receptor
μ
Class
A
Species
Homo sapiens
Ligands
Function
DAMGO
Agonist
BMS-986187
PAM
Reference
—
DAMGO BMS-986187

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Ligand Amino Acid Generic Number Segment Interaction Type
BMS-986187 L118 2.52x52 TM2 hydrophobic
DAMGO Q126 2.60x60 TM2 Van der Waals
DAMGO W135 23.50x50 ECL1 Van der Waals
BMS-986187 I144 3.27x27 TM3 hydrophobic
DAMGO V145 3.28x28 TM3 hydrophobic
DAMGO I146 3.29x29 TM3 hydrophobic
BMS-986187 S147 3.30x30 TM3 Van der Waals
BMS-986187 I148 3.31x31 TM3 hydrophobic
DAMGO D149 3.32x32 TM3 polar (charge-charge)
DAMGO Y150 3.33x33 TM3 Van der Waals
BMS-986187 Y151 3.34x34 TM3 hydrophobic
DAMGO M153 3.36x36 TM3 hydrophobic
BMS-986187 W194 4.50x50 TM4 hydrophobic
BMS-986187 S198 4.54x54 TM4 Van der Waals
BMS-986187 G201 4.57x57 TM4 Van der Waals
BMS-986187 L202 4.58x58 TM4 hydrophobic
BMS-986187 M205 4.61x61 TM4 hydrophobic
DAMGO C219 45.50x50 ECL2 hydrophobic
DAMGO T220 45.51x51 ECL2 Van der Waals
DAMGO V238 5.42x43 TM5 hydrophobic
DAMGO W295 6.48x48 TM6 Van der Waals
DAMGO I298 6.51x51 TM6 hydrophobic
DAMGO H299 6.52x52 TM6 Van der Waals
DAMGO V302 6.55x55 TM6 hydrophobic
DAMGO W320 7.35x34 TM7 hydrophobic
DAMGO I324 7.39x38 TM7 Van der Waals
DAMGO Y328 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A A P T N A S N C T D A L A Y S S C S P A P S P G S W V N L S H L D G N L S D P C G P N R T D L G G R D S L C P P T G S P S N-termC-term P T S S N I E Q Q N S T R I R Q N T R D H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M I T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G T I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I I N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L V T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
Helix box plot — Download: PNG | SVG F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I I N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7

GPCRdb(A)
GPCRdb(A)
μ receptor
TM2
2x52 2.52x52 L118
2x60 2.60x60 Q126
ECL1
23x50 23.50x50 W135
TM3
3x27 3.27x27 I144
3x28 3.28x28 V145
3x29 3.29x29 I146
3x30 3.30x30 S147
3x31 3.31x31 I148
3x32 3.32x32 D149
3x33 3.33x33 Y150
3x34 3.34x34 Y151
3x36 3.36x36 M153
TM4
4x50 4.50x50 W194
4x54 4.54x54 S198
4x57 4.57x57 G201
4x58 4.58x58 L202
4x61 4.61x61 M205
ECL2
45x50 45.50x50 C219
45x51 45.51x51 T220
TM5
5x43 5.42x43 V238
TM6
6x48 6.48x48 W295
6x51 6.51x51 I298
6x52 6.52x52 H299
6x55 6.55x55 V302
TM7
7x34 7.35x34 W320
7x38 7.39x38 I324
7x42 7.43x42 Y328