PDB
9UCO
Resolution
3.6 Å
Released
April 8, 2026
Receptor
ADGRE1
Class
B2
Species
Mus musculus
Ligand
Function
Stalk peptide
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
Stalk peptide F645 1.41x41 TM1 polar (charge-charge)
Stalk peptide F645 1.41x41 TM1 polar (hydrogen bond with backbone)
Stalk peptide S646 1.42x42 TM1 Van der Waals
Stalk peptide L647 1.43x43 TM1 Van der Waals
Stalk peptide Y648 1.44x44 TM1 aromatic (pi-cation)
Stalk peptide Y648 1.44x44 TM1 hydrophobic
Stalk peptide S651 1.47x47 TM1 Van der Waals
Stalk peptide K694 2.68x68 TM2 Van der Waals
Stalk peptide F697 2.71x71 TM2 hydrophobic
Stalk peptide I701 ECL1 hydrophobic
Stalk peptide D702 ECL1 polar (charge-charge)
Stalk peptide F721 3.44x44 TM3 hydrophobic
Stalk peptide R786 ECL2 hydrophobic
Stalk peptide W788 ECL2 hydrophobic
Stalk peptide T791 ECL2 Van der Waals
Stalk peptide I796 5.32x32 TM5 Van der Waals
Stalk peptide F799 5.35x35 TM5 hydrophobic
Stalk peptide L800 5.36x36 TM5 hydrophobic
Stalk peptide V803 5.39x39 TM5 hydrophobic
Stalk peptide W856 6.58x58 TM6 Van der Waals
Stalk peptide G859 6.61x61 TM6 Van der Waals
Stalk peptide I860 ECL3 hydrophobic
Stalk peptide Q862 ECL3 Van der Waals
Stalk peptide A867 7.39x38 TM7 hydrophobic
Stalk peptide S868 7.40x39 TM7 Van der Waals
Stalk peptide A871 7.43x42 TM7 hydrophobic
Stalk peptide W872 7.44x43 TM7 polar (hydrogen bond)
Stalk peptide F874 7.46x45 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 R A V Q ICL1ECL1 D K T D ECL1ICL2 L K V V N Y F S S R N ICL2ECL2 P R G Y G M H N R C W L N T E T ECL2ICL3 S S E V S K L K ICL3ECL3 Q I G P ECL3N-term M W G F W L L L F W G F S G M Y R W G M T T L P T L G Q T L G G V N E C Q D T T T C P A Y A T C T D T T D S Y Y C T C K R G F L S S N G Q T N F Q G P G V E C Q D V N E C L Q S D S P C G P N S V C T N I L G R A K C S C L R G F S S S T G K D W I L G S L D N F L C A D V D E C L T I G I C P K Y S N C S N S V G S Y S C T C Q P G F V L N G S I C E D E D E C V T R D V C P E H A T C H N T L G S Y Y C T C N S G L E S S G G G P M F Q G L D E S C E D V D E C S R N S T L C G P T F I C I N T L G S Y S C S C P A G F S L P T F Q I L G H P A D G N C T D I D E C D D T C P L N S S C T N T I G S Y F C T C H P G F A S S N G Q L N F K D L E V T C E D I D E C T Q D P L Q C G L N S V C T N V P G S Y I C G C L P D F Q M D P E G S Q G Y G N F N C K R I L F K C K E D L I L Q S E Q I Q Q C Q A V Q G R D L G Y A S F C T L V N A T F T I L D N T C E N K S A P V S L Q S A A T S V S L V L E Q A T T W F E L S K E E T S T L G T I L L E T V E S T M L A A L L I P S G N A S Q M I Q T E Y L D I E S K V I N E E C K E N E S I N L A A R G D K M N V G C F I I K E S V S T G A P G V A F V S F A H M E S V L N E R F F E D G Q S F R K L R M N S R V V G G T V T G E K K E D F S K P I I Y T L Q H I Q P K Q K S E R P I C V S W N T D V E D G R W T P S G C E I V E A S E T H T V C S C N R M A N L A I I M A S G N-termC-term H S Q T S G I L L S S M P S T S K M G C-term E L T M E F S L Y I I S H V G T V I S L V C L A L A I A T F L L C N H N T Y M H L H L C V C L F L A K I L F L T G I N Q T A C A I I A G F L H Y L F L A C F F W M L V E A V M L F L M V R N I K M L H L C A F G Y G L P V L V V I I S A S V Q G F I W S F L G P V C M I I T I N S V L L A W T L W V L R Q K L C S V D T R L L T F K A I A Q I F I L G C S W V L G I F L A S I M A Y L F T I I N S L Q G A F I F L I H C L L N R Q Y K K K T D V R D E L L T R L S S !
Helix box plot — Download: PNG | SVG A L C V L S I V T G V H S I I Y L S F E 1 L H L C V C L F L A K I L F L T G I 2 V L M W F F C A L F L Y H L F G A I I A 3 K M L H L C A G F Y G L P V L V V I I S A 4 L L V S N I T I I M C V P G L F S W I F 5 I A Q I F I L G C S W V L G I F 6 L F I F A G Q L S N I I T F L Y A M I 7

GPCRdb(A)
GPCRdb(B)
ADGRE1
TM1
1x37 1.41x41 I649
1x38 1.42x42 I650
1x39 1.43x43 S651
1x40 1.44x44 H652
1x43 1.47x47 T655
TM2
2x61 2.68x68 I701
TM3
3x40 3.44x44 F725
TM5
5x39 5.35x35 F795
5x40 5.36x36 I796
5x43 5.39x39 F799
TM6
6x53 6.58x58 F861
TM7
7x34 7.39x38 A871
7x35 7.40x39 Y872
7x38 7.43x42 T875
7x39 7.44x43 I876
7x41 7.46x45 N878