PDB
9UCO
Resolution
3.6 Å
Released
April 8, 2026
Receptor
ADGRE1
Class
B2
Species
Mus musculus
Ligand
Stalk peptide
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
Stalk peptide Y648 1.44x44 TM1 hydrophobic
Stalk peptide F697 2.71x71 TM2 hydrophobic
Stalk peptide F721 3.44x44 TM3 hydrophobic
Stalk peptide W788 ECL2 hydrophobic
Stalk peptide F799 5.35x35 TM5 hydrophobic
Stalk peptide L800 5.36x36 TM5 hydrophobic
Stalk peptide G859 6.61x61 TM6 polar (hydrogen bond with backbone)
Stalk peptide G859 6.61x61 TM6 Van der Waals
Stalk peptide Q862 ECL3 Van der Waals
Stalk peptide A867 7.39x38 TM7 Van der Waals
Stalk peptide S868 7.40x39 TM7 Van der Waals
Stalk peptide W872 7.44x43 TM7 polar (hydrogen bond)
Stalk peptide W872 7.44x43 TM7 Van der Waals
Stalk peptide F874 7.46x45 TM7 Van der Waals
Stalk peptide F874 7.46x45 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 R A V Q ICL1ECL1 D K T D ECL1ICL2 L K V V N Y F S S R N ICL2ECL2 P R G Y G M H N R C W L N T E T ECL2ICL3 S S E V S K L K ICL3ECL3 Q I G P ECL3N-term M W G F W L L L F W G F S G M Y R W G M T T L P T L G Q T L G G V N E C Q D T T T C P A Y A T C T D T T D S Y Y C T C K R G F L S S N G Q T N F Q G P G V E C Q D V N E C L Q S D S P C G P N S V C T N I L G R A K C S C L R G F S S S T G K D W I L G S L D N F L C A D V D E C L T I G I C P K Y S N C S N S V G S Y S C T C Q P G F V L N G S I C E D E D E C V T R D V C P E H A T C H N T L G S Y Y C T C N S G L E S S G G G P M F Q G L D E S C E D V D E C S R N S T L C G P T F I C I N T L G S Y S C S C P A G F S L P T F Q I L G H P A D G N C T D I D E C D D T C P L N S S C T N T I G S Y F C T C H P G F A S S N G Q L N F K D L E V T C E D I D E C T Q D P L Q C G L N S V C T N V P G S Y I C G C L P D F Q M D P E G S Q G Y G N F N C K R I L F K C K E D L I L Q S E Q I Q Q C Q A V Q G R D L G Y A S F C T L V N A T F T I L D N T C E N K S A P V S L Q S A A T S V S L V L E Q A T T W F E L S K E E T S T L G T I L L E T V E S T M L A A L L I P S G N A S Q M I Q T E Y L D I E S K V I N E E C K E N E S I N L A A R G D K M N V G C F I I K E S V S T G A P G V A F V S F A H M E S V L N E R F F E D G Q S F R K L R M N S R V V G G T V T G E K K E D F S K P I I Y T L Q H I Q P K Q K S E R P I C V S W N T D V E D G R W T P S G C E I V E A S E T H T V C S C N R M A N L A I I M A S G N-termC-term H S Q T S G I L L S S M P S T S K M G C-term E L T M E F S L Y I I S H V G T V I S L V C L A L A I A T F L L C N H N T Y M H L H L C V C L F L A K I L F L T G I N Q T A C A I I A G F L H Y L F L A C F F W M L V E A V M L F L M V R N I K M L H L C A F G Y G L P V L V V I I S A S V Q G F I W S F L G P V C M I I T I N S V L L A W T L W V L R Q K L C S V D T R L L T F K A I A Q I F I L G C S W V L G I F L A S I M A Y L F T I I N S L Q G A F I F L I H C L L N R Q Y K K K T D V R D E L L T R L S S !
Helix box plot — Download: PNG | SVG A L C V L S I V T G V H S I I Y L S F E 1 L H L C V C L F L A K I L F L T G I 2 V L M W F F C A L F L Y H L F G A I I A 3 K M L H L C A G F Y G L P V L V V I I S A 4 L L V S N I T I I M C V P G L F S W I F 5 I A Q I F I L G C S W V L G I F 6 L F I F A G Q L S N I I T F L Y A M I 7

GPCRdb(A)
GPCRdb(B)
ADGRE1
TM1
1x40 1.44x44 H652
TM3
3x40 3.44x44 F725
TM5
5x39 5.35x35 F795
5x40 5.36x36 I796
TM7
7x34 7.39x38 A871
7x35 7.40x39 Y872
7x39 7.44x43 I876
7x41 7.46x45 N878