ADGRE1 - Beta-arrestin-1

GPCR CLASS (FAMILY)

Class B2 (Adhesion)

GPCR SPECIES

Mus musculus

GPCR PREFERRED CHAIN

H

ARRESTIN (FAMILY)

Beta

ARRESTIN

ARRESTIN SPECIES

Bovine

ARRESTIN CHAIN

A

ARRESTIN COVERAGE

83

PDB CODE

RESOLUTION

3.6 Å

REFERENCE

PUBLICATION DATE

April 8, 2026

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

Stalk peptide - Agonist

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Arrestin
segment

AA

Number
Generic
number
Hydrophobic TM3 M 738 3x61 s5s6 E 66 N.s5s6.03
Hydrophobic ICL3 L 841 - s5s6 G 72 N.s5s6.09
Hydrophobic ICL2 S 750 - s8s9 D 135 N.s8s9.06
Ionic TM7 H 889 7x61 s5s6 D 69 N.s5s6.06
Polar TM7 H 889 7x61 s5s6 D 69 N.s5s6.06
Hydrophobic TM7 H 889 7x61 s5s6 D 69 N.s5s6.06
Van-der-waals TM7 H 889 7x61 s5s6 D 69 N.s5s6.06
Hydrophobic ICL2 S 749 - s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 S 749 - s8s9 D 135 N.s8s9.06
Hydrophobic TM3 M 738 3x61 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 M 738 3x61 s5s6 L 68 N.s5s6.05
Hydrophobic ICL3 K 844 - s5s6 V 70 N.s5s6.07
Ionic TM2 H 683 2x57 s5s6 D 69 N.s5s6.06
Hydrophobic TM3 M 738 3x61 s5s6 D 67 N.s5s6.04
Van-der-waals TM3 M 738 3x61 s5s6 D 67 N.s5s6.04
Hydrophobic ICL2 L 742 - s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 L 742 - S5 Y 63 N.S5.12
Van-der-waals ICL2 L 742 - S5 Y 63 N.S5.12
Polar ICL2 S 749 - s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 S 749 - s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 S 749 - s8s9 T 136 N.s8s9.07
Polar ICL1 N 677 - s5s6 D 67 N.s5s6.04
Hydrophobic ICL1 N 677 - s5s6 D 67 N.s5s6.04
Van-der-waals ICL1 N 677 - s5s6 D 67 N.s5s6.04
Hydrophobic ICL3 L 841 - s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 S 750 - s8s9 E 134 N.s8s9.05
Van-der-waals ICL2 S 750 - s8s9 E 134 N.s8s9.05
Polar ICL1 H 678 - s5s6 D 67 N.s5s6.04
Hydrophobic ICL1 H 678 - s5s6 D 67 N.s5s6.04
Van-der-waals ICL1 H 678 - s5s6 D 67 N.s5s6.04
Polar ICL2 S 749 - s5s6 E 66 N.s5s6.03
Polar ICL2 S 749 - s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 S 749 - s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 S 749 - s5s6 R 65 N.s5s6.02
Hydrophobic ICL3 L 841 - s5s6 V 70 N.s5s6.07
Van-der-waals ICL3 L 841 - s5s6 V 70 N.s5s6.07
Hydrophobic ICL1 N 679 - s5s6 D 69 N.s5s6.06
Van-der-waals ICL1 N 679 - s5s6 D 69 N.s5s6.06