PDB
9UYH
Resolution
3.3 Å
Released
Nov. 19, 2025
Receptor
chemerin 2
Class
A
Species
Homo sapiens
Ligand
Function
Chemerin
Agonist
Reference
10.1126/SCIENCE.ADT8794

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Ligand Amino Acid Generic Number Segment Interaction Type
Chemerin F86 2.53x53 TM2 hydrophobic
Chemerin Y93 2.60x60 TM2 aromatic (edge-to-face)
Chemerin Y93 2.60x60 TM2 hydrophobic
Chemerin Y96 2.63x63 TM2 Van der Waals
Chemerin F101 ECL1 hydrophobic
Chemerin F101 ECL1 aromatic (edge-to-face)
Chemerin A117 3.32x32 TM3 Van der Waals
Chemerin Q118 3.33x33 TM3 polar (hydrogen bond)
Chemerin M121 3.36x36 TM3 hydrophobic
Chemerin F181 ECL2 hydrophobic
Chemerin C187 45.50x50 ECL2 Van der Waals
Chemerin Y188 45.51x51 ECL2 Van der Waals
Chemerin N189 45.52x52 ECL2 Van der Waals
Chemerin K210 5.42x43 TM5 Van der Waals
Chemerin W259 6.48x48 TM6 Van der Waals
Chemerin Y262 6.51x51 TM6 Van der Waals
Chemerin E269 6.58x58 TM6 hydrophobic
Chemerin H273 6.62x62 TM6 Van der Waals
Chemerin Y277 ECL3 hydrophobic
Chemerin S278 ECL3 polar (hydrogen bond with backbone)
Chemerin S278 ECL3 hydrophobic
Chemerin H279 ECL3 polar (hydrogen bond)
Chemerin Q283 ECL3 Van der Waals
Chemerin G285 ECL3 Van der Waals
Chemerin I286 ECL3 hydrophobic
Chemerin T290 7.39x38 TM7 hydrophobic
Chemerin A293 7.42x41 TM7 hydrophobic
Chemerin F294 7.43x42 TM7 aromatic (edge-to-face)

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Snake plot — Download: PNG | SVG
ICL1 K K ICL1ECL1 F H W P F ECL1ICL2 P V L S H R H R ICL2ECL2 D T V E F N N H T L C Y N N F Q K H D P D ECL2ICL3 I L I ICL3ECL3 H N S Y S ECL3N-term M E D L E E T L F E E F E N Y S Y D L D Y Y S L E S D L E E K V Q L N-termC-term A E I L K Y T L W E V S C S G T V S E Q L R N S E T K N L C L L E T A Q C-term G V V H W V S L V L Y C L A F V L G I P G N A I V I W F T G F K W T V T T L W F L N L A I A D F I F L L F L P L Y I S Y V A M N G I W L C K A N S F T A Q L N M F A S V F F L T V I S L D H Y I H L I H T L K N S L I V I I F I W L L A S L I G G P A L Y F R L T L I R H H V L T W V K F I I G Y L F P L L T M S I C Y L C L I F K V K K R S S S R H F W T I L V V V V A F V V C W T P Y H L F S I W E L T I H H H V M Q A G I P L S T G L A F L N S C L N P I L Y V L I S K K F R S F Q A R S V
Helix box plot — Download: PNG | SVG A N G P I G L V F A L C Y L V L S V W H 1 L N L A I A D F I F L L F L P L Y I S Y 2 V T L F F V S A F M N L Q A T F S N A K 3 S L I V I I F I W L L A S L I G G P A L 4 Y C I S M T L L P F L Y G I I F K V W T L 5 L V V V V A F V V C W T P Y H L F S I W 6 I P N L C S N L F A L G T S L P I G A 7

GPCRdb(A)
GPCRdb(A)
chemerin receptor 2
TM2
2x53 2.53x53 F86
2x60 2.60x60 Y93
2x63 2.63x63 Y96
TM3
3x32 3.32x32 A117
3x33 3.33x33 Q118
3x36 3.36x36 M121
ECL2
45x50 45.50x50 C187
45x51 45.51x51 Y188
45x52 45.52x52 N189
TM5
5x43 5.42x43 K210
TM6
6x48 6.48x48 W259
6x51 6.51x51 Y262
6x58 6.58x58 E269
6x62 6.62x62 H273
TM7
7x38 7.39x38 T290
7x41 7.42x41 A293
7x42 7.43x42 F294