chemerin receptor 2 - Beta-arrestin-1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

ARRESTIN (FAMILY)

Beta

ARRESTIN

Beta-arrestin-1

ARRESTIN SPECIES

Human

ARRESTIN CHAIN

A

ARRESTIN COVERAGE

81

PDB CODE

9UYH

RESOLUTION

3.3 Å

REFERENCE

10.1126/SCIENCE.ADT8794

PUBLICATION DATE

Nov. 19, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

54 interactions (Click to see)

LIGANDS

Chemerin - Agonist

PHYSIOLOGICAL LIGANDS

chemerin (Human)



GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 142 - S5 Y 63 N.S5.12
Hydrophobic C-term L 1365 - H1 K 107 N.H1.09
Hydrophobic TM1 W 67 1x61 s5s6 L 68 N.s5s6.05
Hydrophobic TM7 Y 304 7x53 s5s6 L 71 N.s5s6.08
Van-der-waals TM7 Y 304 7x53 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 H 141 - S5 Y 63 N.S5.12
Van-der-waals ICL2 H 141 - S5 Y 63 N.S5.12
Ionic H8 K 309 8x48 s5s6 D 67 N.s5s6.04
Polar H8 K 309 8x48 s5s6 D 67 N.s5s6.04
Hydrophobic H8 K 309 8x48 s5s6 D 67 N.s5s6.04
Van-der-waals H8 K 309 8x48 s5s6 D 67 N.s5s6.04
Hydrophobic TM6 T 247 6x36 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 T 247 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic C-term L 1365 - H1 R 103 N.H1.05
Van-der-waals C-term L 1365 - H1 R 103 N.H1.05
Hydrophobic H8 K 309 8x48 s5s6 L 68 N.s5s6.05
Hydrophobic TM3 H 135 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 P 142 - S15 I 241 C.S15.14
Hydrophobic TM6 R 243 6x32 s5s6 G 72 N.s5s6.09
Polar ICL1 K 68 - s8s9 T 136 N.s8s9.07
Hydrophobic ICL1 K 68 - s8s9 T 136 N.s8s9.07
Hydrophobic TM5 Y 226 5x58 s5s6 L 71 N.s5s6.08
Polar ICL2 H 141 - s5s6 R 65 N.s5s6.02
Hydrophobic TM3 H 138 3x53 s5s6 L 73 N.s5s6.10
Hydrophobic ICL3 I 238 - s15s16 F 244 C.s15s16.03
Van-der-waals ICL3 I 238 - s15s16 F 244 C.s15s16.03
Hydrophobic TM6 I 248 6x37 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 H 138 3x53 s5s6 V 70 N.s5s6.07
Polar C-term A 1366 - H1 R 103 N.H1.05
Van-der-waals C-term A 1366 - H1 R 103 N.H1.05
Hydrophobic TM3 H 135 3x50 s5s6 L 73 N.s5s6.10
Van-der-waals TM3 H 135 3x50 s5s6 L 73 N.s5s6.10
Hydrophobic TM3 H 135 3x50 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 H 135 3x50 s5s6 L 71 N.s5s6.08
Polar TM2 T 70 2x37 s5s6 E 66 N.s5s6.03
Hydrophobic TM2 T 70 2x37 s5s6 E 66 N.s5s6.03
Van-der-waals TM2 T 70 2x37 s5s6 E 66 N.s5s6.03
Polar H8 S 308 8x47 s5s6 D 69 N.s5s6.06
Hydrophobic H8 S 308 8x47 s5s6 D 69 N.s5s6.06
Van-der-waals H8 S 308 8x47 s5s6 D 69 N.s5s6.06
Hydrophobic TM2 F 76 2x43 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 F 76 2x43 s5s6 V 70 N.s5s6.07
Hydrophobic C-term L 1365 - S1 V 8 N.S1.01
Van-der-waals C-term L 1365 - S1 V 8 N.S1.01
Hydrophobic ICL2 I 140 - s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 I 140 - s15s16 N 245 C.s15s16.04
Hydrophobic TM4 L 151 4x39 s8s9 E 134 N.s8s9.05
Hydrophobic ICL3 L 239 - s15s16 F 244 C.s15s16.03
Hydrophobic TM6 H 244 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 H 244 6x33 s5s6 L 73 N.s5s6.10
Polar C-term L 1365 - ns1 T 6 N.ns1.14
Hydrophobic C-term L 1365 - ns1 T 6 N.ns1.14
Van-der-waals C-term L 1365 - ns1 T 6 N.ns1.14
Polar ICL2 P 142 - S16 Y 249 C.S16.03
Hydrophobic ICL2 P 142 - S16 Y 249 C.S16.03
Van-der-waals ICL2 P 142 - S16 Y 249 C.S16.03
Hydrophobic TM2 F 76 2x43 s5s6 L 68 N.s5s6.05
Hydrophobic C-term L 1365 - H1 L 104 N.H1.06
Polar ICL2 V 143 - S16 Y 249 C.S16.03
Hydrophobic ICL2 V 143 - S16 Y 249 C.S16.03
Van-der-waals ICL2 V 143 - S16 Y 249 C.S16.03
Polar H8 K 309 8x48 s5s6 E 66 N.s5s6.03
Van-der-waals H8 K 309 8x48 s5s6 E 66 N.s5s6.03
Polar TM6 H 244 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 H 244 6x33 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 H 244 6x33 s5s6 L 71 N.s5s6.08