PDB
9UYL
Resolution
3.3 Å
Released
Nov. 19, 2025
Receptor
chemerin 2
Class
A
Species
Homo sapiens
Ligand
Chemerin
Function
Agonist
Reference
10.1126/SCIENCE.ADT8794

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Ligand Amino Acid Generic Number Segment Interaction Type
Chemerin Y93 2.60x60 TM2 hydrophobic
Chemerin C110 3.25x25 TM3 hydrophobic
Chemerin Q118 3.33x33 TM3 polar (hydrogen bond)
Chemerin Q118 3.33x33 TM3 Van der Waals
Chemerin R176 ECL2 Van der Waals
Chemerin D177 ECL2 polar (charge-assisted hydrogen bond)
Chemerin C187 45.50x50 ECL2 hydrophobic
Chemerin N190 ECL2 Van der Waals
Chemerin N190 ECL2 polar (hydrogen bond)
Chemerin Y262 6.51x51 TM6 Van der Waals
Chemerin Y262 6.51x51 TM6 polar (hydrogen bond)
Chemerin Y277 ECL3 Van der Waals
Chemerin Y277 ECL3 hydrophobic
Chemerin S278 ECL3 Van der Waals
Chemerin H279 7.28x27 TM7 Van der Waals
Chemerin H280 7.29x28 TM7 aromatic (edge-to-face)
Chemerin H280 7.29x28 TM7 Van der Waals
Chemerin M282 7.31x30 TM7 Van der Waals
Chemerin M282 7.31x30 TM7 hydrophobic

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ICL1 K K ICL1ECL1 F H W P F ECL1ICL2 P V L S H R H R ICL2ECL2 D T V E F N N H T L C Y N N F Q K H D P D ECL2ICL3 I L I ICL3ECL3 H N S Y S ECL3N-term M E D L E E T L F E E F E N Y S Y D L D Y Y S L E S D L E E K V Q L N-termC-term A E I L K Y T L W E V S C S G T V S E Q L R N S E T K N L C L L E T A Q C-term G V V H W V S L V L Y C L A F V L G I P G N A I V I W F T G F K W T V T T L W F L N L A I A D F I F L L F L P L Y I S Y V A M N G I W L C K A N S F T A Q L N M F A S V F F L T V I S L D H Y I H L I H T L K N S L I V I I F I W L L A S L I G G P A L Y F R L T L I R H H V L T W V K F I I G Y L F P L L T M S I C Y L C L I F K V K K R S S S R H F W T I L V V V V A F V V C W T P Y H L F S I W E L T I H H H V M Q A G I P L S T G L A F L N S C L N P I L Y V L I S K K F R S F Q A R S V
Helix box plot — Download: PNG | SVG A N G P I G L V F A L C Y L V L S V W H 1 L N L A I A D F I F L L F L P L Y I S Y 2 V T L F F V S A F M N L Q A T F S N A K 3 S L I V I I F I W L L A S L I G G P A L 4 Y C I S M T L L P F L Y G I I F K V W T L 5 L V V V V A F V V C W T P Y H L F S I W 6 I P N L C S N L F A L G T S L P I G A 7

GPCRdb(A)
GPCRdb(A)
chemerin receptor 2
TM2
2x60 2.60x60 Y93
TM3
3x25 3.25x25 C110
3x33 3.33x33 Q118
ECL2
45x50 45.50x50 C187
TM6
6x51 6.51x51 Y262
TM7
7x27 7.28x27 H279
7x28 7.29x28 H280
7x30 7.31x30 M282