chemerin receptor 2 - Beta-arrestin-1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

ARRESTIN (FAMILY)

Beta

ARRESTIN

Beta-arrestin-1

ARRESTIN SPECIES

Human

ARRESTIN CHAIN

A

ARRESTIN COVERAGE

77

PDB CODE

9UYL

RESOLUTION

3.3 Å

REFERENCE

10.1126/SCIENCE.ADT8794

PUBLICATION DATE

Nov. 19, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

39 interactions (Click to see)

LIGANDS

Chemerin - Agonist

PHYSIOLOGICAL LIGANDS

chemerin (Human)



GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 H 146 - S16 Y 249 C.S16.03
Hydrophobic ICL2 P 142 - s15s16 L 243 C.s15s16.02
Hydrophobic ICL2 P 142 - S5 Y 63 N.S5.12
Van-der-waals ICL2 P 142 - S5 Y 63 N.S5.12
Hydrophobic ICL2 H 146 - s17s18 G 286 C.s17s18.12
Van-der-waals ICL2 H 146 - s17s18 G 286 C.s17s18.12
Hydrophobic ICL2 S 145 - S8 L 129 N.S8.03
Polar ICL2 R 149 - s17s18 R 285 C.s17s18.11
Hydrophobic ICL2 R 149 - s17s18 R 285 C.s17s18.11
Van-der-waals ICL2 R 149 - s17s18 R 285 C.s17s18.11
Hydrophobic ICL2 S 145 - s17s18 G 286 C.s17s18.12
Hydrophobic ICL2 H 146 - S16 V 251 C.S16.05
Polar C-term C 1358 - s1s2 P 14 N.s1s2.02
Hydrophobic C-term C 1358 - s1s2 P 14 N.s1s2.02
Van-der-waals C-term C 1358 - s1s2 P 14 N.s1s2.02
Hydrophobic ICL2 S 145 - s17s18 R 285 C.s17s18.11
Van-der-waals ICL2 S 145 - s17s18 R 285 C.s17s18.11
Polar C-term C 1358 - s1s2 S 13 N.s1s2.01
Hydrophobic C-term C 1358 - s1s2 S 13 N.s1s2.01
Van-der-waals C-term C 1358 - s1s2 S 13 N.s1s2.01
Hydrophobic C-term L 1365 - H1 R 103 N.H1.05
Hydrophobic ICL2 V 143 - S15 I 241 C.S15.14
Polar ICL2 H 146 - S16 K 250 C.S16.04
Van-der-waals ICL2 H 146 - S16 K 250 C.S16.04
Polar C-term C 1358 - S1 A 12 N.S1.05
Hydrophobic C-term C 1358 - S1 A 12 N.S1.05
Van-der-waals C-term C 1358 - S1 A 12 N.S1.05
Polar C-term A 1366 - H1 R 103 N.H1.05
Hydrophobic ICL2 H 141 - s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 H 141 - s15s16 F 244 C.s15s16.03
Polar ICL2 H 146 - s17s18 R 285 C.s17s18.11
Hydrophobic ICL2 H 146 - s17s18 R 285 C.s17s18.11
Van-der-waals ICL2 H 146 - s17s18 R 285 C.s17s18.11
Hydrophobic C-term L 1365 - S1 V 8 N.S1.01
Van-der-waals C-term L 1365 - S1 V 8 N.S1.01
Hydrophobic ICL2 P 142 - s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 P 142 - s15s16 F 244 C.s15s16.03
Hydrophobic C-term L 1365 - ns1 T 6 N.ns1.14
Hydrophobic TM4 T 150 4x38 s17s18 R 285 C.s17s18.11
Van-der-waals TM4 T 150 4x38 s17s18 R 285 C.s17s18.11
Hydrophobic C-term C 1358 - S1 K 11 N.S1.04
Polar C-term A 1361 - S1 K 10 N.S1.03
Hydrophobic C-term A 1361 - S1 K 10 N.S1.03
Van-der-waals C-term A 1361 - S1 K 10 N.S1.03
Hydrophobic ICL2 H 141 - s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 H 141 - s15s16 N 245 C.s15s16.04
Hydrophobic C-term L 1365 - H1 L 104 N.H1.06
Polar ICL2 V 143 - S16 Y 249 C.S16.03
Hydrophobic ICL2 V 143 - S16 Y 249 C.S16.03
Van-der-waals ICL2 V 143 - S16 Y 249 C.S16.03