PDB
9VJT
Resolution
3.0 Å
Released
June 24, 2026
Receptor
μ
Class
A
Species
Homo sapiens
Ligand
(-)-methadone
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
(-)-methadone D149 3.32x32 TM3 polar (charge-assisted hydrogen bond)
(-)-methadone Y150 3.33x33 TM3 aromatic (face-to-edge)
(-)-methadone Y150 3.33x33 TM3 Van der Waals
(-)-methadone M153 3.36x36 TM3 hydrophobic
(-)-methadone M153 3.36x36 TM3 Van der Waals
(-)-methadone F154 3.37x37 TM3 hydrophobic
(-)-methadone F154 3.37x37 TM3 Van der Waals
(-)-methadone V238 5.42x43 TM5 hydrophobic
(-)-methadone V238 5.42x43 TM5 Van der Waals
(-)-methadone W295 6.48x48 TM6 hydrophobic
(-)-methadone W295 6.48x48 TM6 Van der Waals
(-)-methadone I298 6.51x51 TM6 hydrophobic
(-)-methadone I298 6.51x51 TM6 Van der Waals
(-)-methadone H299 6.52x52 TM6 Van der Waals
(-)-methadone I324 7.39x38 TM7 hydrophobic
(-)-methadone I324 7.39x38 TM7 Van der Waals
(-)-methadone G327 7.42x41 TM7 Van der Waals
(-)-methadone Y328 7.43x42 TM7 aromatic (face-to-face)
(-)-methadone Y328 7.43x42 TM7 Van der Waals

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ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A A P T N A S N C T D A L A Y S S C S P A P S P G S W V N L S H L D G N L S D P C G P N R T D L G G R D S L C P P T G S P S N-termC-term P T S S N I E Q Q N S T R I R Q N T R D H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M I T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G T I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I I N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L V T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
Helix box plot — Download: PNG | SVG F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I I N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7

GPCRdb(A)
GPCRdb(A)
μ receptor
TM3
3x32 3.32x32 D149
3x33 3.33x33 Y150
3x36 3.36x36 M153
3x37 3.37x37 F154
TM5
5x43 5.42x43 V238
TM6
6x48 6.48x48 W295
6x51 6.51x51 I298
6x52 6.52x52 H299
TM7
7x38 7.39x38 I324
7x41 7.42x41 G327
7x42 7.43x42 Y328