μ receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9VJT

RESOLUTION

3.0 Å

REFERENCE

PUBLICATION DATE

June 24, 2026

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

33 interactions (Click to see)

LIGANDS

(-)-methadone - Agonist pubchem gtoplig chembl_ligand drugbank drug_central pubchem gtoplig chembl_ligand drug_central drugbank pubchem

PHYSIOLOGICAL LIGANDS

[Met]enkephalin (Human), dynorphin A-(1-8) (Human), dynorphin A (Human), dynorphin A-(1-13) (Human), β-endorphin (Mouse), endomorphin-1 (Human), β-endorphin (Rat), dynorphin B (Human), β-endorphin (Human), [Leu]enkephalin (Human), endomorphin-2 (Human)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 L 261 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 261 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM2 T 105 2x39 G.H5 C 351 G.H5.23
Polar TM6 K 273 6x26 G.h4s6 K 314 G.h4s6.08
Van-der-waals TM6 K 273 6x26 G.h4s6 K 314 G.h4s6.08
Hydrophobic H8 D 342 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 D 342 8x47 G.H5 G 352 G.H5.24
Hydrophobic ICL3 R 265 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 R 265 - G.S6 Y 320 G.S6.02
Polar ICL2 R 181 - G.H5 C 351 G.H5.23
Hydrophobic ICL2 R 181 - G.H5 C 351 G.H5.23
Van-der-waals ICL2 R 181 - G.H5 C 351 G.H5.23
Hydrophobic TM4 R 184 4x40 G.HN R 24 G.HN.48
Hydrophobic TM6 N 276 6x29 G.H5 F 354 G.H5.26
Hydrophobic ICL2 P 174 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 174 - G.H5 I 343 G.H5.15
Hydrophobic ICL2 P 174 - G.H5 T 340 G.H5.12
Hydrophobic TM6 I 280 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 280 6x33 G.H5 L 353 G.H5.25
Polar H8 E 343 8x48 G.H5 G 352 G.H5.24
Hydrophobic H8 E 343 8x48 G.H5 G 352 G.H5.24
Van-der-waals H8 E 343 8x48 G.H5 G 352 G.H5.24
Hydrophobic ICL2 P 174 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 174 - G.H5 I 344 G.H5.16
Polar H8 N 344 8x49 G.H5 D 350 G.H5.22
Hydrophobic TM3 R 167 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 178 - G.H5 I 343 G.H5.15
Ionic ICL2 D 179 - G.hns1 R 32 G.hns1.03
Polar ICL2 D 179 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 D 179 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 D 179 - G.hns1 R 32 G.hns1.03
Hydrophobic TM6 M 283 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 M 283 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM5 M 257 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 M 257 5x61 G.H5 L 353 G.H5.25
Hydrophobic H8 E 343 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 E 343 8x48 G.H5 F 354 G.H5.26
Hydrophobic TM3 V 171 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 171 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL3 L 267 - G.H5 F 354 G.H5.26
Hydrophobic TM3 A 170 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 170 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM5 R 260 5x64 G.H5 I 344 G.H5.16
Polar TM3 A 170 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 170 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 170 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL3 M 266 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 M 266 - G.H5 K 345 G.H5.17
Ionic ICL2 R 181 - G.H5 D 350 G.H5.22
Polar ICL2 R 181 - G.H5 D 350 G.H5.22
Van-der-waals ICL2 R 181 - G.H5 D 350 G.H5.22
Hydrophobic TM6 I 280 6x33 G.H5 F 354 G.H5.26
Hydrophobic ICL3 M 266 - G.H5 F 354 G.H5.26
Hydrophobic TM2 T 103 2x37 G.H5 D 350 G.H5.22
Ionic TM6 K 273 6x26 G.h4s6 E 318 G.h4s6.12
Polar TM6 K 273 6x26 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 K 273 6x26 G.h4s6 E 318 G.h4s6.12