PDB
9WST
Resolution
2.8 Å
Released
Nov. 26, 2025
Receptor
μ
Class
A
Species
Mus musculus
Ligand
DAMGO
Function
Agonist
Reference
10.1038/S41422-025-01191-8

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Ligand Amino Acid Generic Number Segment Interaction Type
DAMGO W133 23.50x50 ECL1 hydrophobic
DAMGO V143 3.28x28 TM3 hydrophobic
DAMGO I144 3.29x29 TM3 hydrophobic
DAMGO M151 3.36x36 TM3 hydrophobic
DAMGO T218 45.51x51 ECL2 Van der Waals
DAMGO T218 45.51x51 ECL2 polar (hydrogen bond)
DAMGO V236 5.42x43 TM5 Van der Waals
DAMGO V236 5.42x43 TM5 hydrophobic
DAMGO I296 6.51x51 TM6 hydrophobic
DAMGO I296 6.51x51 TM6 Van der Waals
DAMGO W318 7.35x34 TM7 hydrophobic
DAMGO W318 7.35x34 TM7 Van der Waals
DAMGO I322 7.39x38 TM7 hydrophobic
DAMGO I322 7.39x38 TM7 Van der Waals
DAMGO Y326 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A G P G N I S D C S D P L A P A S C S P A P G S W L N L S H V D G N Q S D P C G P N R T G L G G S H S L C P Q T G S P S N-termC-term P T S S T I E Q Q N S A R I R Q N T R E H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M V T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G N I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I V N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L I T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
Helix box plot — Download: PNG | SVG F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I V N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7

GPCRdb(A)
GPCRdb(A)
μ receptor
ECL1
23x50 23.50x50 W133
TM3
3x28 3.28x28 V143
3x29 3.29x29 I144
3x36 3.36x36 M151
ECL2
45x51 45.51x51 T218
TM5
5x43 5.42x43 V236
TM6
6x51 6.51x51 I296
TM7
7x34 7.35x34 W318
7x38 7.39x38 I322
7x42 7.43x42 Y326