PDB
9XF4
Resolution
3.1 Å
Released
July 8, 2026
Receptor
δ
Class
A
Species
Homo sapiens
Ligands
Function
[Leu]enkephalin (Human)
Agonist
BMS-986187
Ago-PAM
Reference
—
[Leu]enkephalin (Human) BMS-986187

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Ligand Amino Acid Generic Number Segment Interaction Type
BMS-986187 L97 2.52x52 TM2 hydrophobic
[Leu]enkephalin (Human) Q105 2.60x60 TM2 hydrophobic
[Leu]enkephalin (Human) K108 2.63x63 TM2 polar (hydrogen bond)
[Leu]enkephalin (Human) K108 2.63x63 TM2 hydrophobic
BMS-986187 L119 3.23x23 TM3 hydrophobic
BMS-986187 K122 3.26x26 TM3 Van der Waals
BMS-986187 A123 3.27x27 TM3 hydrophobic
[Leu]enkephalin (Human) V124 3.28x28 TM3 hydrophobic
[Leu]enkephalin (Human) L125 3.29x29 TM3 hydrophobic
BMS-986187 S126 3.30x30 TM3 Van der Waals
BMS-986187 I127 3.31x31 TM3 Van der Waals
[Leu]enkephalin (Human) D128 3.32x32 TM3 Van der Waals
[Leu]enkephalin (Human) Y129 3.33x33 TM3 Van der Waals
BMS-986187 Y130 3.34x34 TM3 Van der Waals
BMS-986187 N131 3.35x35 TM3 Van der Waals
[Leu]enkephalin (Human) M132 3.36x36 TM3 hydrophobic
BMS-986187 S177 4.54x54 TM4 Van der Waals
BMS-986187 G180 4.57x57 TM4 Van der Waals
BMS-986187 V181 4.58x58 TM4 hydrophobic
BMS-986187 M184 4.61x61 TM4 hydrophobic
[Leu]enkephalin (Human) R192 ECL2 polar (charge-charge)
[Leu]enkephalin (Human) K214 5.39x40 TM5 Van der Waals
[Leu]enkephalin (Human) V217 5.42x43 TM5 Van der Waals
[Leu]enkephalin (Human) I277 6.51x51 TM6 hydrophobic
[Leu]enkephalin (Human) H278 6.52x52 TM6 Van der Waals
[Leu]enkephalin (Human) V281 6.55x55 TM6 Van der Waals
[Leu]enkephalin (Human) I304 7.39x38 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 V T R P R D G A V V C M L Q F P S ECL2ICL3 R L L S G ICL3ECL3 D I D R R ECL3N-term M E P A P S A G A E L Q P P L F A N A S D A Y P S A C P S A G A N A S G P P N-termC-term P C G R P D P S S F S R A R E A T A R E R V T A C T P S D G P G G G A A A C-term G A R S A S S L A L A I A I T A L Y S A V C A V G L L G N V L V M F G I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S A K Y L M E G E L L C K A V L S I D Y Y N M F T S I F T L T M M S V D R Y I A V C H T P A K A K L I N I C I W V L A S G V G V P I M V M A P S W Y W D T V T K I C V F L F A F V V P I L I I T V C Y G L M L L R L R S V S K E K D R S L R R I T R M V L V V V G A F V V C W A P I H I F V I V W T L V D P L V V A A L H L C I A L G Y A N S S L N P V L Y A F L D E N F R Q F K R C L C R K
Helix box plot — Download: PNG | SVG V N G L L G V A C V A S Y L A T I A I A 1 F N L A L A D A L A T S T L P F Q S A K 2 M T L T F I S T F M N Y Y D I S L V A K 3 A K L I N I C I W V L A S G V G V P I M 4 Y C V T I I L I P V V F A F L F V C I K T 5 L V V V G A F V V C W A P I H I F V I V 6 V P N L S S N A Y G L A I C L H L A A 7

GPCRdb(A)
GPCRdb(A)
δ receptor
TM2
2x52 2.52x52 L97
2x60 2.60x60 Q105
2x63 2.63x63 K108
TM3
3x23 3.23x23 L119
3x26 3.26x26 K122
3x27 3.27x27 A123
3x28 3.28x28 V124
3x29 3.29x29 L125
3x30 3.30x30 S126
3x31 3.31x31 I127
3x32 3.32x32 D128
3x33 3.33x33 Y129
3x34 3.34x34 Y130
3x35 3.35x35 N131
3x36 3.36x36 M132
TM4
4x54 4.54x54 S177
4x57 4.57x57 G180
4x58 4.58x58 V181
4x61 4.61x61 M184
TM5
5x40 5.39x40 K214
5x43 5.42x43 V217
TM6
6x51 6.51x51 I277
6x52 6.52x52 H278
6x55 6.55x55 V281
TM7
7x38 7.39x38 I304