δ receptor - Gi2

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9XF4

RESOLUTION

3.1 Å

REFERENCE

PUBLICATION DATE

July 8, 2026

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

52 interactions (Click to see)

LIGANDS

[Leu]enkephalin (Human) - Agonist pubchem gtoplig chembl_ligand uniprot uniprot uniprot pubchem ,

BMS-986187 - Ago-PAM pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

[Met]enkephalin (Human), dynorphin A (Human), dynorphin A-(1-8) (Human), dynorphin A-(1-13) (Human), β-endorphin (Mouse), endomorphin-1 (Human), β-endorphin (Rat), dynorphin B (Human), β-endorphin (Human), α-neoendorphin (Human), [Leu]enkephalin (Human)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 R 244 - G.H5 D 342 G.H5.13
Van-der-waals ICL3 R 244 - G.H5 D 342 G.H5.13
Hydrophobic ICL2 P 153 34x50 G.H5 I 344 G.H5.15
Ionic ICL2 D 158 34x55 G.hns1 R 32 G.hns1.03
Polar ICL2 D 158 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 D 158 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 D 158 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM3 V 150 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 V 150 3x54 G.H5 L 349 G.H5.20
Hydrophobic ICL3 V 243 - G.H5 D 342 G.H5.13
Van-der-waals ICL3 V 243 - G.H5 D 342 G.H5.13
Hydrophobic TM5 L 240 5x65 G.H5 L 349 G.H5.20
Van-der-waals TM5 L 240 5x65 G.H5 L 349 G.H5.20
Hydrophobic TM5 M 236 5x61 G.H5 L 354 G.H5.25
Hydrophobic ICL2 P 153 34x50 G.H5 T 341 G.H5.12
Hydrophobic TM3 A 149 3x53 G.H5 C 352 G.H5.23
Van-der-waals TM3 A 149 3x53 G.H5 C 352 G.H5.23
Hydrophobic ICL2 L 157 34x54 G.hns1 R 32 G.hns1.03
Polar H8 E 323 8x48 G.H5 G 353 G.H5.24
Hydrophobic H8 E 323 8x48 G.H5 G 353 G.H5.24
Hydrophobic TM6 I 259 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 I 259 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 R 258 6x32 G.H5 F 355 G.H5.26
Hydrophobic TM5 R 239 5x64 G.H5 I 345 G.H5.16
Van-der-waals ICL3 R 244 - G.h4s6 E 319 G.h4s6.12
Ionic ICL2 R 160 34x57 G.H5 D 351 G.H5.22
Polar ICL2 R 160 34x57 G.H5 D 351 G.H5.22
Hydrophobic TM6 M 262 6x36 G.H5 L 354 G.H5.25
Ionic TM6 K 252 6x26 G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL3 R 244 - G.S6 Y 321 G.S6.02
Van-der-waals ICL3 R 244 - G.S6 Y 321 G.S6.02
Polar H8 R 327 8x52 G.H5 F 355 G.H5.26
Ionic TM5 R 239 5x64 G.H5 D 342 G.H5.13
Polar TM6 R 258 6x32 G.H5 L 354 G.H5.25
Hydrophobic TM6 R 258 6x32 G.H5 L 354 G.H5.25
Van-der-waals TM6 R 258 6x32 G.H5 L 354 G.H5.25
Hydrophobic ICL2 P 153 34x50 G.H5 I 345 G.H5.16
Hydrophobic TM4 T 161 4x38 G.HN E 28 G.HN.52
Hydrophobic TM6 S 255 6x29 G.H5 F 355 G.H5.26
Hydrophobic ICL3 L 245 - G.H5 D 342 G.H5.13
Van-der-waals ICL3 L 245 - G.H5 D 342 G.H5.13
Hydrophobic TM3 R 146 3x50 G.H5 L 354 G.H5.25
Hydrophobic ICL3 L 245 - G.H5 K 346 G.H5.17
Van-der-waals ICL3 L 245 - G.H5 K 346 G.H5.17
Hydrophobic ICL3 L 246 - G.H5 L 349 G.H5.20
Polar H8 R 327 8x52 G.H5 K 350 G.H5.21
Hydrophobic TM5 L 240 5x65 G.H5 I 345 G.H5.16
Hydrophobic TM6 E 251 6x25 G.h4s6 D 316 G.h4s6.09
Van-der-waals TM6 E 251 6x25 G.h4s6 D 316 G.h4s6.09
Polar TM3 A 149 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 A 149 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 A 149 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 V 150 3x54 G.H5 I 345 G.H5.16
Hydrophobic H8 D 322 8x47 G.H5 G 353 G.H5.24
Van-der-waals H8 D 322 8x47 G.H5 G 353 G.H5.24
Polar ICL2 R 160 34x57 G.H5 C 352 G.H5.23
Hydrophobic ICL2 R 160 34x57 G.H5 C 352 G.H5.23
Van-der-waals ICL2 R 160 34x57 G.H5 C 352 G.H5.23