β3-adrenoceptor (adrb3_human)
FAMILY
Class A (Rhodopsin) Aminergic receptors Adrenoceptors β3-adrenoceptor
GENE
ADRB3 (ADRB3R, B3AR)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Beta-3 adrenergic receptor, Beta-3 adrenoreceptor, Beta-3 adrenoceptor
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
A
|
P
|
W
|
P
|
H
|
E
|
N
|
S
|
S
|
10 |
L
|
A
|
P
|
W
|
P
|
D
|
L
|
P
|
T
|
L
|
20 |
A
|
P
|
N
|
T
|
A
|
N
|
T
|
S
|
G
|
L
|
30 |
TM1 | |||||||||
P
|
G
|
V
|
P
|
W
|
E
|
A
|
A
|
L
|
A
|
40 |
G
|
A
|
L
|
L
|
A
|
L
|
A
|
V
|
L
|
A
|
50 |
T
|
V
|
G
|
G
|
N
|
L
|
L
|
V
|
I
|
V
|
60 |
ICL1 | |||||||||
A
|
I
|
A
|
W
|
T
|
P
|
R
|
L
|
Q
|
T
|
70 |
TM2 | |||||||||
M
|
T
|
N
|
V
|
F
|
V
|
T
|
S
|
L
|
A
|
80 |
A
|
A
|
D
|
L
|
V
|
M
|
G
|
L
|
L
|
V
|
90 |
V
|
P
|
P
|
A
|
A
|
T
|
L
|
A
|
L
|
T
|
100 |
ECL1 | TM3 | ||||||||
G
|
H
|
W
|
P
|
L
|
G
|
A
|
T
|
G
|
C
|
110 |
E
|
L
|
W
|
T
|
S
|
V
|
D
|
V
|
L
|
C
|
120 |
V
|
T
|
A
|
S
|
I
|
E
|
T
|
L
|
C
|
A
|
130 |
L
|
A
|
V
|
D
|
R
|
Y
|
L
|
A
|
V
|
T
|
140 |
ICL2 | |||||||||
N
|
P
|
L
|
R
|
Y
|
G
|
A
|
L
|
V
|
T
|
150 |
TM4 | |||||||||
K
|
R
|
C
|
A
|
R
|
T
|
A
|
V
|
V
|
L
|
160 |
V
|
W
|
V
|
V
|
S
|
A
|
A
|
V
|
S
|
F
|
170 |
ECL2 | |||||||||
A
|
P
|
I
|
M
|
S
|
Q
|
W
|
W
|
R
|
V
|
180 |
G
|
A
|
D
|
A
|
E
|
A
|
Q
|
R
|
C
|
H
|
190 |
S
|
N
|
P
|
R
|
C
|
C
|
A
|
F
|
A
|
S
|
200 |
TM5 | |||||||||
N
|
M
|
P
|
Y
|
V
|
L
|
L
|
S
|
S
|
S
|
210 |
V
|
S
|
F
|
Y
|
L
|
P
|
L
|
L
|
V
|
M
|
220 |
L
|
F
|
V
|
Y
|
A
|
R
|
V
|
F
|
V
|
V
|
230 |
A
|
T
|
R
|
Q
|
L
|
R
|
L
|
L
|
R
|
G
|
240 |
ICL3 | |||||||||
E
|
L
|
G
|
R
|
F
|
P
|
P
|
E
|
E
|
S
|
250 |
P
|
P
|
A
|
P
|
S
|
R
|
S
|
L
|
A
|
P
|
260 |
A
|
P
|
V
|
G
|
T
|
C
|
A
|
P
|
P
|
E
|
270 |
G
|
V
|
P
|
A
|
C
|
G
|
R
|
R
|
P
|
A
|
280 |
TM6 | |||||||||
R
|
L
|
L
|
P
|
L
|
R
|
E
|
H
|
R
|
A
|
290 |
L
|
C
|
T
|
L
|
G
|
L
|
I
|
M
|
G
|
T
|
300 |
F
|
T
|
L
|
C
|
W
|
L
|
P
|
F
|
F
|
L
|
310 |
A
|
N
|
V
|
L
|
R
|
A
|
L
|
G
|
G
|
P
|
320 |
ECL3 | TM7 | ||||||||
S
|
L
|
V
|
P
|
G
|
P
|
A
|
F
|
L
|
A
|
330 |
L
|
N
|
W
|
L
|
G
|
Y
|
A
|
N
|
S
|
A
|
340 |
H8 | |||||||||
F
|
N
|
P
|
L
|
I
|
Y
|
C
|
R
|
S
|
P
|
350 |
D
|
F
|
R
|
S
|
A
|
F
|
R
|
R
|
L
|
L
|
360 |
C-term | |||||||||
C
|
R
|
C
|
G
|
R
|
R
|
L
|
P
|
P
|
E
|
370 |
P
|
C
|
A
|
A
|
A
|
R
|
P
|
A
|
L
|
F
|
380 |
P
|
S
|
G
|
V
|
P
|
A
|
A
|
R
|
S
|
S
|
390 |
P
|
A
|
Q
|
P
|
R
|
L
|
C
|
Q
|
R
|
L
|
400 |
D
|
G
|
A
|
S
|
W
|
G
|
V
|
S
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
ENDOGENOUS LIGANDS
(-)-adrenaline, (-)-noradrenaline, (+)-adrenaline, (±)-adrenaline
STRUCTURE MODELS
STRUCTURES
No structures available