FPR2/ALX (fpr2_human)

FAMILY

Class A (Rhodopsin) Peptide receptors Formylpeptide receptors FPR2/ALX

GENE

FPR2 (FPRH1, FPRL1, LXA4R)

ORGANISM

Human (Homo sapiens)

ALT. NAMES

N-formyl peptide receptor 2, FMLP-related receptor I, FMLP-R-I, Formyl peptide receptor-like 1, HM63, Lipoxin A4 receptor, LXA4 receptor, RFP

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
E
T
N
F
S
T
P
L
N
10
                   
E
Y
E
E
V
S
Y
E
S
A
20
TM1              
G
Y
T
V
L
R
I
L
P
L
30
                   
V
V
L
G
V
T
F
V
L
G
40
                   
V
L
G
N
G
L
V
I
W
V
50
          ICL1 TM2
A
G
F
R
M
T
R
T
V
T
60
               
T
I
C
Y
L
N
L
A
L
A
70
                   
D
F
S
F
T
A
T
L
P
F
80
                   
L
I
V
S
M
A
M
G
E
K
90
ECL1 TM3      
W
P
F
G
W
F
L
C
K
L
100
                   
I
H
I
V
V
D
I
N
L
F
110
                   
G
S
V
F
L
I
G
F
I
A
120
                   
L
D
R
C
I
C
V
L
H
P
130
ICL2       TM4
V
W
A
Q
N
H
R
T
V
S
140
                   
L
A
M
K
V
I
V
G
P
W
150
                   
I
L
A
L
V
L
T
L
P
V
160
        ECL2    
F
L
F
L
T
T
V
T
I
P
170
                   
N
G
D
T
Y
C
T
F
N
F
180
          TM5    
A
S
W
G
G
T
P
E
E
R
190
                   
L
K
V
A
I
T
M
L
T
A
200
                   
R
G
I
I
R
F
V
I
G
F
210
                   
S
L
P
M
S
I
V
A
I
C
220
                   
Y
G
L
I
A
A
K
I
H
K
230
    ICL3 TM6  
K
G
M
I
K
S
S
R
P
L
240
                   
R
V
L
T
A
V
V
A
S
F
250
                   
F
I
C
W
F
P
F
Q
L
V
260
                   
A
L
L
G
T
V
W
L
K
E
270
ECL3     TM7  
M
L
F
Y
G
K
Y
K
I
I
280
                   
D
I
L
V
N
P
T
S
S
L
290
                   
A
F
F
N
S
C
L
N
P
M
300
          H8      
L
Y
V
F
V
G
Q
D
F
R
310
                   
E
R
L
I
H
S
L
P
T
S
320
C-term        
L
E
R
A
L
S
E
D
S
A
330
                   
P
T
N
D
T
A
A
N
S
A
340
                   
S
P
P
A
E
T
E
L
Q
A
350
 
M

LINKS

ChEMBL

Guide To Pharmacology

UniProt

DIAGRAMS

ICL1 T R ICL1ECL1 E K W P F ECL1ICL2 P V W A Q N H R ICL2ECL2 T T V T I P N G D T Y C T F N F A S W G G ECL2ICL3 M I K S ICL3ECL3 L K E M L F Y G K ECL3N-term M E T N F S T P L N E Y E E V S Y E N-termC-term P T S L E R A L S E D S A P T N D T A A N S A S P P A E T E L Q A M C-term S A G Y T V L R I L P L V V L G V T F V L G V L G N G L V I W V A G F R M T V T T I C Y L N L A L A D F S F T A T L P F L I V S M A M G G W F L C K L I H I V V D I N L F G S V F L I G F I A L D R C I C V L H T V S L A M K V I V G P W I L A L V L T L P V F L F L T P E E R L K V A I T M L T A R G I I R F V I G F S L P M S I V A I C Y G L I A A K I H K K G S R P L R V L T A V V A S F F I C W F P F Q L V A L L G T V W Y K I I D I L V N P T S S L A F F N S C L N P M L Y V F V G Q D L I H F R E R S L
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

G N G L V G L V F T V G L V V L P L I R 1 L N L A L A D F S F T A T L P F L I V S 2 F G I L F V S G F L N I D V V I H I L K 3 A M K V I V G P W I L A L V L T L P V 4 Y C I A V I S M P L S F G I V F R I I G R 5 T A V V A S F F I C W F P F Q L V A L L 6 M P N L C S N F F A L S S T P N V L I 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

1 mutation data points available.

ENDOGENOUS LIGANDS

resolvin D1, serum amyloid A, 15-deoxy-LXA4, LTC4, LL-37, humanin, LTD4, aspirin triggered lipoxin A4, annexin I, aspirin-triggered resolvin D1, fMet-Leu-Phe, PrP106-126, LXA4

STRUCTURE MODELS

fpr2_human active,

fpr2_human inactive

STRUCTURES

Found 9 structure(s) - view all details on the Structures page

PDBs: 6OMM, 6LW5, 7T6U, 7T6S, 7T6V, 7WVV, 7WVW, 7WVX, 7WVY