FPR2/ALX - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7T6U

RESOLUTION

2.9 Å

REFERENCE

10.1038/S41467-022-28586-0

PUBLICATION DATE

March 30, 2022

3D VIEW

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LIGAND INTERACTIONS

59 interactions (Click to see)

LIGANDS

synthetic peptide - Agonist

PHYSIOLOGICAL LIGANDS

LXA4, serum amyloid A, PrP106-126, aspirin-triggered resolvin D1, humanin, aspirin triggered lipoxin A4, LL-37, annexin I, resolvin D1



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 130 34x50 G.H5 I 344 G.H5.16
Hydrophobic ICL2 Q 134 34x54 G.H5 I 343 G.H5.15
Hydrophobic ICL2 V 131 34x51 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 V 131 34x51 G.s2s3 D 193 G.s2s3.02
Polar TM6 R 238 6x32 G.H5 G 352 G.H5.24
Polar TM6 R 238 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 238 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 238 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 P 239 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 P 239 6x33 G.H5 F 354 G.H5.26
Polar TM4 S 140 4x40 G.HN E 28 G.HN.52
Hydrophobic TM4 S 140 4x40 G.HN E 28 G.HN.52
Van-der-waals TM4 S 140 4x40 G.HN E 28 G.HN.52
Polar ICL3 K 235 - G.h4s6 K 314 G.h4s6.08
Hydrophobic ICL2 V 131 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 V 131 34x51 G.H5 F 336 G.H5.08
Hydrophobic ICL3 M 233 - G.H5 D 341 G.H5.13
Hydrophobic ICL2 P 130 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL2 P 130 34x50 G.H5 T 340 G.H5.12
Van-der-waals ICL2 P 130 34x50 G.H5 T 340 G.H5.12
Hydrophobic TM5 I 228 5x65 G.H5 L 348 G.H5.20
Polar TM2 Y 64 2x43 G.H5 C 351 G.H5.23
Van-der-waals TM2 Y 64 2x43 G.H5 C 351 G.H5.23
Polar TM6 P 239 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 P 239 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 P 239 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL3 M 233 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 M 233 - G.H5 F 354 G.H5.26
Polar ICL2 N 135 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 N 135 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM7 V 305 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 V 305 7x56 G.H5 G 352 G.H5.24
Polar ICL2 Q 134 34x54 G.S1 E 33 G.S1.01
Ionic ICL3 K 235 - G.h4s6 E 318 G.h4s6.12
Polar ICL2 N 135 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 N 135 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 N 135 34x55 G.hns1 R 32 G.hns1.03
Polar ICL2 Q 134 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 Q 134 34x54 G.hns1 A 31 G.hns1.02
Polar TM3 R 123 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 123 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 123 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL3 M 233 - G.H5 K 345 G.H5.17
Hydrophobic TM3 V 127 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 V 127 3x54 G.H5 I 344 G.H5.16
Hydrophobic H8 G 306 8x47 G.H5 G 352 G.H5.24
Polar TM3 C 126 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 C 126 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 Q 134 34x54 G.S1 V 34 G.S1.02
Van-der-waals ICL2 Q 134 34x54 G.S1 V 34 G.S1.02
Hydrophobic TM3 V 127 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 127 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM6 L 243 6x37 G.H5 L 353 G.H5.25
Ionic TM5 K 231 5x68 G.H5 D 341 G.H5.13
Polar TM5 K 231 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 K 231 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 K 231 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM2 T 60 2x39 G.H5 D 350 G.H5.22
Polar TM4 T 138 4x38 G.HN E 28 G.HN.52
Hydrophobic TM4 T 138 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 T 138 4x38 G.HN E 28 G.HN.52
Hydrophobic TM5 I 224 5x61 G.H5 L 353 G.H5.25
Hydrophobic ICL2 Q 134 34x54 G.S3 L 194 G.S3.01
Hydrophobic ICL2 V 131 34x51 G.S3 L 194 G.S3.01
Polar ICL2 N 135 34x55 G.S3 H 195 G.S3.02
Hydrophobic TM5 K 227 5x64 G.H5 I 344 G.H5.16
Polar ICL2 Q 134 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 Q 134 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 Q 134 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL3 M 233 - G.H5 I 344 G.H5.16
Van-der-waals ICL3 M 233 - G.H5 I 344 G.H5.16