GPER (gper1_human)
FAMILY
Class A (Rhodopsin) Steroid receptors Estrogen (G protein-coupled) receptors GPER
GENE
GPER1 (CEPR, CMKRL2, DRY12, GPER, GPR30)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
G-protein coupled estrogen receptor 1, Chemoattractant receptor-like 2, Flow-induced endothelial G-protein coupled receptor 1, FEG-1, G protein-coupled estrogen receptor 1, G-protein coupled receptor 30, GPCR-Br, IL8-related receptor DRY12, Lymphocyte-derived G-protein coupled receptor, LYGPR, Membrane estrogen receptor, mER
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
D
|
V
|
T
|
S
|
Q
|
A
|
R
|
G
|
V
|
10 |
G
|
L
|
E
|
M
|
Y
|
P
|
G
|
T
|
A
|
Q
|
20 |
P
|
A
|
A
|
P
|
N
|
T
|
T
|
S
|
P
|
E
|
30 |
L
|
N
|
L
|
S
|
H
|
P
|
L
|
L
|
G
|
T
|
40 |
A
|
L
|
A
|
N
|
G
|
T
|
G
|
E
|
L
|
S
|
50 |
TM1 | |||||||||
E
|
H
|
Q
|
Q
|
Y
|
V
|
I
|
G
|
L
|
F
|
60 |
L
|
S
|
C
|
L
|
Y
|
T
|
I
|
F
|
L
|
F
|
70 |
P
|
I
|
G
|
F
|
V
|
G
|
N
|
I
|
L
|
I
|
80 |
L
|
V
|
V
|
N
|
I
|
S
|
F
|
R
|
E
|
K
|
90 |
ICL1 | TM2 | ||||||||
M
|
T
|
I
|
P
|
D
|
L
|
Y
|
F
|
I
|
N
|
100 |
L
|
A
|
V
|
A
|
D
|
L
|
I
|
L
|
V
|
A
|
110 |
D
|
S
|
L
|
I
|
E
|
V
|
F
|
N
|
L
|
H
|
120 |
ECL1 | TM3 | ||||||||
E
|
R
|
Y
|
Y
|
D
|
I
|
A
|
V
|
L
|
C
|
130 |
T
|
F
|
M
|
S
|
L
|
F
|
L
|
Q
|
V
|
N
|
140 |
M
|
Y
|
S
|
S
|
V
|
F
|
F
|
L
|
T
|
W
|
150 |
M
|
S
|
F
|
D
|
R
|
Y
|
I
|
A
|
L
|
A
|
160 |
ICL2 | |||||||||
R
|
A
|
M
|
R
|
C
|
S
|
L
|
F
|
R
|
T
|
170 |
TM4 | |||||||||
K
|
H
|
H
|
A
|
R
|
L
|
S
|
C
|
G
|
L
|
180 |
I
|
W
|
M
|
A
|
S
|
V
|
S
|
A
|
T
|
L
|
190 |
V
|
P
|
F
|
T
|
A
|
V
|
H
|
L
|
Q
|
H
|
200 |
ECL2 | |||||||||
T
|
D
|
E
|
A
|
C
|
F
|
C
|
F
|
A
|
D
|
210 |
TM5 | |||||||||
V
|
R
|
E
|
V
|
Q
|
W
|
L
|
E
|
V
|
T
|
220 |
L
|
G
|
F
|
I
|
V
|
P
|
F
|
A
|
I
|
I
|
230 |
G
|
L
|
C
|
Y
|
S
|
L
|
I
|
V
|
R
|
V
|
240 |
ICL3 | |||||||||
L
|
V
|
R
|
A
|
H
|
R
|
H
|
R
|
G
|
L
|
250 |
TM6 | |||||||||
R
|
P
|
R
|
R
|
Q
|
K
|
A
|
L
|
R
|
M
|
260 |
I
|
L
|
A
|
V
|
V
|
L
|
V
|
F
|
F
|
V
|
270 |
C
|
W
|
L
|
P
|
E
|
N
|
V
|
F
|
I
|
S
|
280 |
V
|
H
|
L
|
L
|
Q
|
R
|
T
|
Q
|
P
|
G
|
290 |
ECL3 | TM7 | ||||||||
A
|
A
|
P
|
C
|
K
|
Q
|
S
|
F
|
R
|
H
|
300 |
A
|
H
|
P
|
L
|
T
|
G
|
H
|
I
|
V
|
N
|
310 |
L
|
A
|
A
|
F
|
S
|
N
|
S
|
C
|
L
|
N
|
320 |
H8 | |||||||||
P
|
L
|
I
|
Y
|
S
|
F
|
L
|
G
|
E
|
T
|
330 |
F
|
R
|
D
|
K
|
L
|
R
|
L
|
Y
|
I
|
E
|
340 |
C-term | |||||||||
Q
|
K
|
T
|
N
|
L
|
P
|
A
|
L
|
N
|
R
|
350 |
F
|
C
|
H
|
A
|
A
|
L
|
K
|
A
|
V
|
I
|
360 |
P
|
D
|
S
|
T
|
E
|
Q
|
S
|
D
|
V
|
R
|
370 |
F
|
S
|
S
|
A
|
V
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
17β-estradiol