IP receptor (pi2r_human)

FAMILY

Class A (Rhodopsin) Lipid receptors Prostanoid receptors IP receptor

GENE

PTGIR (PRIPR)

ORGANISM

Human (Homo sapiens)

ALT. NAMES

Prostacyclin receptor, Prostaglandin I2 receptor, PGI receptor, PGI2 receptor, Prostanoid IP receptor

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
A
D
S
C
R
N
L
T
Y
10
            TM1  
V
R
G
S
V
G
P
A
T
S
20
                   
T
L
M
F
V
A
G
V
V
G
30
                   
N
G
L
A
L
G
I
L
S
A
40
  ICL1   TM2  
R
R
P
A
R
P
S
A
F
A
50
                   
V
L
V
T
G
L
A
A
T
D
60
                   
L
L
G
T
S
F
L
S
P
A
70
                   
V
F
V
A
Y
A
R
N
S
S
80
ECL1            
L
L
G
L
A
R
G
G
P
A
90
TM3              
L
C
D
A
F
A
F
A
M
T
100
                   
F
F
G
L
A
S
M
L
I
L
110
                   
F
A
M
A
V
E
R
C
L
A
120
      ICL2      
L
S
H
P
Y
L
Y
A
Q
L
130
  TM4            
D
G
P
R
C
A
R
L
A
L
140
                   
P
A
I
Y
A
F
C
V
L
F
150
                   
C
A
L
P
L
L
G
L
G
Q
160
ECL2            
H
Q
Q
Y
C
P
G
S
W
C
170
              TM5
F
L
R
M
R
W
A
Q
P
G
180
                   
G
A
A
F
S
L
A
Y
A
G
190
                   
L
V
A
L
L
V
A
A
I
F
200
                   
L
C
N
G
S
V
T
L
S
L
210
                   
C
R
M
Y
R
Q
Q
K
R
H
220
  ICL3          
Q
G
S
L
G
P
R
P
R
T
230
    TM6          
G
E
D
E
V
D
H
L
I
L
240
                   
L
A
L
M
T
V
V
M
A
V
250
                   
C
S
L
P
L
T
I
R
C
F
260
          ECL3  
T
Q
A
V
A
P
D
S
S
S
270
      TM7        
E
M
G
D
L
L
A
F
R
F
280
                   
Y
A
F
N
P
I
L
D
P
W
290
          H8      
V
F
I
L
F
R
K
A
V
F
300
                   
Q
R
L
K
L
W
V
C
C
L
310
      C-term  
C
L
G
P
A
H
G
D
S
Q
320
                   
T
P
L
S
Q
L
A
S
G
R
330
                   
R
D
P
R
A
P
S
A
P
V
340
                   
G
K
E
G
S
C
V
P
L
S
350
                   
A
W
G
E
G
Q
V
E
P
L
360
                   
P
P
T
Q
Q
S
S
G
S
A
370
                   
V
G
T
S
S
K
A
E
A
S
380
           
V
A
C
S
L
C

LINKS

ChEMBL

Guide To Pharmacology

UniProt

DIAGRAMS

7TM

ICL1 R P A R P ICL1ECL1 S S L L G L A R G G ECL1ICL2 P Y L Y A Q L D ICL2ECL2 L G Q H Q Q Y C P G S W C F L R M R W A ECL2ICL3 G S L G P R P R T G E ICL3ECL3 P D S S S E M G ECL3N-term M A D S C R N L T Y V R G S V G N-termC-term P A H G D S Q T P L S Q L A S G R R D P R A P S A P V G K E G S C V P L S A W G E G Q V E P L P P T Q Q S S G S A V G T S S K A E A S V A C S L C C-term P A T S T L M F V A G V V G N G L A L G I L S A R S A F A V L V T G L A A T D L L G T S F L S P A V F V A Y A R N P A L C D A F A F A M T F F G L A S M L I L F A M A V E R C L A L S H G P R C A R L A L P A I Y A F C V L F C A L P L L G Q P G G A A F S L A Y A G L V A L L V A A I F L C N G S V T L S L C R M Y R Q Q K R H Q D E V D H L I L L A L M T V V M A V C S L P L T I R C F T Q A V A D L L A F R F Y A F N P I L D P W V F I L F R K A L K L L C L V F Q R W V C C G
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

G N G V V G A V F M L T S T A P 1 T G L A A T D L L G T S F L S P A V F V 2 A F L I L M S A L G F F T M A F A F A D 3 A R L A L P A I Y A F C V L F C A L P L 4 S G N C L F I A A V L L A V L G A Y A L 5 A L M T V V M A V C S L P L T I R C F T 6 W P D L I P N F A Y F R F A L L D 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

82 mutation data points available.

PHYSIOLOGICAL LIGANDS

PGF2α, PGI2, PGD2, thromboxane A2, PGE1, PGE2

STRUCTURE MODELS

pi2r_human active,

pi2r_human inactive

STRUCTURES

Found 2 structure(s) - view all details on the Structures page

PDBs: 8X79, 8X7A