IP receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8X7A

RESOLUTION

2.6 Å

REFERENCE

10.1126/SCIADV.ADK5184

PUBLICATION DATE

March 6, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

63 interactions (Click to see)

LIGANDS

treprostinil - Agonist pubchem gtoplig chembl_ligand drugbank drug_central

PHYSIOLOGICAL LIGANDS

PGF2α, PGI2, PGD2, thromboxane A2, PGE1, PGE2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM5 Q 217 5x70 G.H5 R 375 G.H5.17
Hydrophobic TM5 Q 217 5x70 G.H5 R 375 G.H5.17
Van-der-waals TM5 Q 217 5x70 G.H5 R 375 G.H5.17
Polar TM5 Q 221 5x74 G.H4 R 332 G.H4.12
Hydrophobic ICL3 G 222 - G.H4 L 336 G.H4.16
Van-der-waals ICL3 G 222 - G.H4 L 336 G.H4.16
Van-der-waals ICL2 D 131 34x57 G.HN Q 35 G.HN.52
Hydrophobic TM3 A 120 3x53 G.H5 Y 381 G.H5.23
Van-der-waals TM3 A 120 3x53 G.H5 Y 381 G.H5.23
Ionic TM6 H 237 6x33 G.H5 E 382 G.H5.24
Polar TM6 H 237 6x33 G.H5 E 382 G.H5.24
Hydrophobic TM6 H 237 6x33 G.H5 E 382 G.H5.24
Van-der-waals TM6 H 237 6x33 G.H5 E 382 G.H5.24
Van-der-waals ICL2 A 128 34x54 G.hns1 R 38 G.hns1.02
Polar ICL2 P 124 34x50 G.H5 H 377 G.H5.19
Hydrophobic ICL2 P 124 34x50 G.H5 H 377 G.H5.19
Polar TM5 R 219 5x72 G.H4 R 332 G.H4.12
Hydrophobic TM1 R 41 1x60 G.H5 L 384 G.H5.26
Van-der-waals TM1 R 41 1x60 G.H5 L 384 G.H5.26
Hydrophobic TM1 L 38 1x57 G.H5 L 383 G.H5.25
Van-der-waals TM1 L 38 1x57 G.H5 L 383 G.H5.25
Hydrophobic ICL2 Y 125 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 Y 125 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL1 R 45 - G.H5 L 384 G.H5.26
Van-der-waals ICL1 R 45 - G.H5 L 384 G.H5.26
Hydrophobic TM5 M 213 5x66 G.H5 Q 374 G.H5.16
Van-der-waals TM5 M 213 5x66 G.H5 Q 374 G.H5.16
Hydrophobic TM5 Q 217 5x70 G.h4s6 Y 348 G.h4s6.20
Van-der-waals TM5 Q 217 5x70 G.h4s6 Y 348 G.h4s6.20
Hydrophobic TM1 I 37 1x56 G.H5 L 383 G.H5.25
Hydrophobic H8 R 296 8x47 G.H5 E 382 G.H5.24
Van-der-waals H8 R 296 8x47 G.H5 E 382 G.H5.24
Polar TM3 L 121 3x54 G.H5 Q 374 G.H5.16
Hydrophobic TM3 L 121 3x54 G.H5 Q 374 G.H5.16
Van-der-waals TM3 L 121 3x54 G.H5 Q 374 G.H5.16
Aromatic TM2 F 49 2x39 G.H5 Y 381 G.H5.23
Hydrophobic TM2 F 49 2x39 G.H5 Y 381 G.H5.23
Van-der-waals TM2 F 49 2x39 G.H5 Y 381 G.H5.23
Hydrophobic TM5 L 210 5x63 G.H5 L 378 G.H5.20
Ionic ICL2 D 131 34x57 G.HN K 34 G.HN.51
Polar ICL2 D 131 34x57 G.HN K 34 G.HN.51
Van-der-waals ICL2 D 131 34x57 G.HN K 34 G.HN.51
Hydrophobic ICL2 P 124 34x50 G.H5 R 370 G.H5.12
Van-der-waals ICL2 P 124 34x50 G.H5 R 370 G.H5.12
Polar TM3 S 122 3x55 G.H5 R 370 G.H5.12
Van-der-waals TM3 S 122 3x55 G.H5 R 370 G.H5.12
Hydrophobic ICL2 P 124 34x50 G.H5 I 373 G.H5.15
Van-der-waals ICL2 P 124 34x50 G.H5 I 373 G.H5.15
Hydrophobic TM3 A 120 3x53 G.H5 H 377 G.H5.19
Van-der-waals TM3 A 120 3x53 G.H5 H 377 G.H5.19
Hydrophobic TM6 H 237 6x33 G.H5 L 378 G.H5.20
Van-der-waals TM6 H 237 6x33 G.H5 L 378 G.H5.20
Hydrophobic TM3 L 121 3x54 G.H5 Y 381 G.H5.23
Van-der-waals TM3 L 121 3x54 G.H5 Y 381 G.H5.23
Hydrophobic ICL2 Y 125 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 Y 125 34x51 G.S3 V 217 G.S3.01
Ionic TM6 D 233 6x29 G.H5 R 379 G.H5.21
Polar TM6 D 233 6x29 G.H5 R 379 G.H5.21
Van-der-waals TM6 D 233 6x29 G.H5 R 379 G.H5.21
Hydrophobic H8 V 299 8x50 G.H5 L 383 G.H5.25
Van-der-waals H8 V 299 8x50 G.H5 L 383 G.H5.25
Polar ICL2 Y 127 34x53 G.H5 Q 380 G.H5.22
Polar TM1 R 41 1x60 G.H5 L 383 G.H5.25
Hydrophobic TM1 R 41 1x60 G.H5 L 383 G.H5.25
Van-der-waals TM1 R 41 1x60 G.H5 L 383 G.H5.25
Hydrophobic TM3 L 121 3x54 G.H5 L 378 G.H5.20
Van-der-waals TM3 L 121 3x54 G.H5 L 378 G.H5.20
Hydrophobic ICL2 P 124 34x50 G.H5 Q 374 G.H5.16
Van-der-waals ICL2 P 124 34x50 G.H5 Q 374 G.H5.16
Polar ICL2 Y 125 34x51 G.H5 F 366 G.H5.08
Aromatic ICL2 Y 125 34x51 G.H5 F 366 G.H5.08
Hydrophobic ICL2 Y 125 34x51 G.H5 F 366 G.H5.08
Van-der-waals ICL2 Y 125 34x51 G.H5 F 366 G.H5.08
Hydrophobic TM5 H 220 5x73 G.S6 Y 350 G.S6.02
Polar TM3 E 116 3x49 G.H5 Y 381 G.H5.23
Hydrophobic TM3 E 116 3x49 G.H5 Y 381 G.H5.23
Van-der-waals TM3 E 116 3x49 G.H5 Y 381 G.H5.23
Hydrophobic TM2 F 49 2x39 G.H5 L 383 G.H5.25
Hydrophobic ICL2 Y 125 34x51 G.H5 C 369 G.H5.11
Van-der-waals ICL2 Y 125 34x51 G.H5 C 369 G.H5.11
Polar H8 R 296 8x47 G.H5 Y 381 G.H5.23
Hydrophobic H8 R 296 8x47 G.H5 Y 381 G.H5.23
Polar TM5 H 220 5x73 G.H4 R 332 G.H4.12
Van-der-waals TM5 H 220 5x73 G.H4 R 332 G.H4.12
Hydrophobic ICL2 Y 125 34x51 G.S3 F 219 G.S3.03
Van-der-waals ICL2 Y 125 34x51 G.S3 F 219 G.S3.03
Aromatic TM3 H 123 3x56 G.H5 R 370 G.H5.12
Hydrophobic ICL2 Y 125 34x51 G.H5 I 373 G.H5.15
Van-der-waals ICL2 Y 125 34x51 G.H5 I 373 G.H5.15
Hydrophobic ICL1 R 42 - G.H5 L 383 G.H5.25
Van-der-waals ICL1 R 42 - G.H5 L 383 G.H5.25
Polar ICL2 Y 125 34x51 G.H5 R 370 G.H5.12
Hydrophobic ICL2 Y 125 34x51 G.H5 R 370 G.H5.12
Van-der-waals ICL2 Y 125 34x51 G.H5 R 370 G.H5.12
Ionic TM6 E 234 6x30 G.H5 R 375 G.H5.17
Polar TM6 E 234 6x30 G.H5 R 375 G.H5.17
Aromatic ICL2 Y 127 34x53 G.H5 H 377 G.H5.19
Hydrophobic ICL2 Y 127 34x53 G.H5 H 377 G.H5.19
Van-der-waals ICL2 Y 127 34x53 G.H5 H 377 G.H5.19
Hydrophobic ICL2 Q 129 34x55 G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 Q 129 34x55 G.hns1 A 39 G.hns1.03
Polar TM3 R 117 3x50 G.H5 Y 381 G.H5.23
Hydrophobic TM3 R 117 3x50 G.H5 Y 381 G.H5.23
Van-der-waals TM3 R 117 3x50 G.H5 Y 381 G.H5.23
Polar TM1 R 41 1x60 G.H5 E 382 G.H5.24