ORF74 (q76sf8_hhv8)
FAMILY
Class A (Rhodopsin) Other Unclassified ORF74
GENE
ORF74 (HHV8GK18_gp84)
ORGANISM
HHV-8 (Human herpesvirus 8)
ALT. NAMES
G protein-coupled receptor, IL-8 receptor-like G protein coupled receptor homolog, ORF74, Putative G-protein coupled receptor
SOURCE
TREMBL
SEQUENCE
N-term | |||||||||
M
|
A
|
A
|
E
|
D
|
F
|
L
|
T
|
I
|
F
|
10 |
L
|
D
|
D
|
D
|
E
|
S
|
W
|
N
|
E
|
T
|
20 |
L
|
N
|
M
|
S
|
G
|
Y
|
D
|
Y
|
S
|
G
|
30 |
N
|
F
|
S
|
L
|
E
|
V
|
S
|
V
|
C
|
E
|
40 |
TM1 | |||||||||
M
|
T
|
T
|
V
|
V
|
P
|
Y
|
T
|
W
|
N
|
50 |
V
|
G
|
I
|
L
|
S
|
L
|
I
|
F
|
L
|
I
|
60 |
N
|
V
|
L
|
G
|
N
|
G
|
L
|
V
|
T
|
Y
|
70 |
I
|
F
|
C
|
K
|
H
|
R
|
S
|
R
|
A
|
G
|
80 |
TM2 | |||||||||
A
|
I
|
D
|
I
|
L
|
L
|
L
|
G
|
I
|
C
|
90 |
L
|
N
|
S
|
L
|
C
|
L
|
S
|
I
|
S
|
L
|
100 |
L
|
A
|
E
|
V
|
L
|
M
|
F
|
L
|
F
|
P
|
110 |
ECL1 | TM3 | ||||||||
N
|
I
|
I
|
S
|
T
|
G
|
L
|
C
|
R
|
L
|
120 |
E
|
I
|
F
|
F
|
Y
|
Y
|
L
|
Y
|
V
|
Y
|
130 |
L
|
D
|
I
|
F
|
S
|
V
|
V
|
C
|
V
|
S
|
140 |
L
|
V
|
R
|
Y
|
L
|
L
|
V
|
A
|
Y
|
S
|
150 |
ICL2 | TM4 | ||||||||
T
|
R
|
S
|
W
|
P
|
K
|
K
|
Q
|
S
|
L
|
160 |
G
|
W
|
V
|
L
|
T
|
S
|
A
|
A
|
L
|
L
|
170 |
I
|
A
|
L
|
V
|
L
|
S
|
G
|
D
|
A
|
C
|
180 |
ECL2 | |||||||||
R
|
H
|
R
|
S
|
R
|
V
|
V
|
D
|
P
|
V
|
190 |
S
|
K
|
Q
|
A
|
M
|
C
|
Y
|
E
|
N
|
A
|
200 |
TM5 | |||||||||
G
|
N
|
M
|
T
|
A
|
D
|
W
|
R
|
L
|
H
|
210 |
V
|
R
|
T
|
V
|
S
|
V
|
T
|
A
|
G
|
F
|
220 |
L
|
L
|
P
|
L
|
A
|
L
|
L
|
I
|
L
|
F
|
230 |
Y
|
A
|
L
|
T
|
W
|
C
|
V
|
V
|
R
|
R
|
240 |
ICL3 | TM6 | ||||||||
T
|
K
|
L
|
Q
|
A
|
R
|
R
|
K
|
V
|
R
|
250 |
G
|
V
|
I
|
V
|
A
|
V
|
V
|
L
|
L
|
F
|
260 |
F
|
V
|
F
|
C
|
F
|
P
|
Y
|
H
|
V
|
L
|
270 |
N
|
L
|
L
|
D
|
T
|
L
|
L
|
R
|
R
|
R
|
280 |
ECL3 | TM7 | ||||||||
W
|
I
|
R
|
D
|
S
|
C
|
Y
|
T
|
R
|
G
|
290 |
L
|
I
|
N
|
V
|
G
|
L
|
A
|
V
|
T
|
S
|
300 |
L
|
L
|
Q
|
A
|
L
|
Y
|
S
|
A
|
V
|
V
|
310 |
H8 | |||||||||
P
|
L
|
I
|
Y
|
S
|
C
|
L
|
G
|
S
|
L
|
320 |
F
|
R
|
Q
|
R
|
M
|
Y
|
G
|
L
|
F
|
Q
|
330 |
S
|
L
|
R
|
Q
|
S
|
F
|
M
|
S
|
G
|
A
|
340 |
C-term | |||||
T
|
T
|
||||
LINKS
DIAGRAMS
7TM
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
No physiological ligands available
STRUCTURE MODELS
No structure models have been generated as experimental structures are available (see below).
STRUCTURES
Found 2 structure(s) - view all details on the Structures page