Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A



GPCRdb(A)
5-HT1B
Human
5-HT1B
C. hamster
5-HT1B
Cat
5-HT1B
Rat
5-HT1B
Mouse
5-HT1B
W. lowland ..
5-HT1B
Guinea pig
5-HT1B
Bovine
TM1
1x28 S45 A41 A44 A41 A41 A45 A44 A60
1x29 L46 L42 L45 L42 L42 L46 L45 L61
1x30 P47 P43 P46 P43 P43 P47 P46 P62
1x31 W48 W44 W47 W44 W44 W48 W47 W63
1x32 K49 K45 K48 K45 K45 K49 K48 K64
1x33 V50 V46 V49 V46 V46 V50 V49 V65
1x34 L51 L47 L50 L47 L47 L51 L50 V66
1x35 L52 L48 L51 L48 L48 L52 L51 V67
1x36 V53 V49 I52 V49 V49 V53 V52 V68
1x37 M54 A50 L53 A50 A50 M54 V53 L69
1x38 L55 L51 V54 L51 L51 L55 L54 L70
1x39 L56 L52 L55 L52 L52 L56 L55 L71
1x40 A57 A53 A56 A53 A53 A57 A56 A72
1x41 L58 L54 L57 L54 L54 L58 L57 L73
1x42 I59 I55 F58 I55 I55 I59 I58 F74
1x43 T60 T56 T59 T56 T56 T60 T59 T75
1x44 L61 L57 L60 L57 L57 L61 L60 L76
1x45 A62 A58 A61 A58 A58 A62 A61 A77
1x46 T63 T59 T62 T59 T59 T63 T62 T78
1x47 T64 T60 T63 T60 T60 T64 T63 T79
1x48 L65 L61 L64 L61 L61 L65 L64 L80
1x49 S66 S62 S65 S62 S62 S66 S65 S81
1x50 N67 N63 N66 N63 N63 N67 N66 N82
1x51 A68 A64 A67 A64 A64 A68 A67 A83
1x52 F69 F65 F68 F65 F65 F69 F68 F84
1x53 V70 V66 V69 V66 V66 V70 V69 V85
1x54 I71 I67 I70 I67 I67 I71 I70 I86
1x55 A72 A68 A71 A68 A68 A72 A71 A87
1x56 T73 T69 T72 T69 T69 T73 T72 T88
1x57 V74 V70 V73 V70 V70 V74 V73 V89
1x58 Y75 Y71 Y74 Y71 Y71 Y75 Y74 Y90
1x59 R76 R72 R75 R72 R72 R76 R75 R91
1x60 T77 T73 T76 T73 T73 T77 T76 T92
ICL1
12x48 R78 R74 R77 R74 R74 R78 R77 R93
12x49 K79 K75 K78 K75 K75 K79 K78 K94
12x50 L80 L76 L79 L76 L76 L80 L79 L95
12x51 H81 H77 H80 H77 H77 H81 H80 H96
TM2
2x37 T82 T78 T81 T78 T78 T82 T81 T97
2x38 P83 P79 P82 P79 P79 P83 P82 P98
2x39 A84 A80 A83 A80 A80 A84 A83 A99
2x40 N85 N81 N84 N81 N81 N85 N84 N100
2x41 Y86 Y82 Y85 Y82 Y82 Y86 Y85 Y101
2x42 L87 L83 L86 L83 L83 L87 L86 L102
2x43 I88 I84 I87 I84 I84 I88 I87 I103
2x44 A89 A85 A88 A85 A85 A89 A88 A104
2x45 S90 S86 S89 S86 S86 S90 S89 S105
2x46 L91 L87 L90 L87 L87 L91 L90 L106
2x47 A92 A88 A91 A88 A88 A92 A91 A107
2x48 V93 V89 V92 V89 V89 V93 F92 V108
2x49 T94 T90 T93 T90 T90 T94 T93 T109
2x50 D95 D91 D94 D91 D91 D95 D94 D110
2x51 L96 L92 L95 L92 L92 L96 L95 L111
2x52 L97 L93 L96 L93 L93 L97 L96 L112
2x53 V98 V94 V97 V94 V94 V98 V97 V113
2x54 S99 S95 S98 S95 S95 S99 S98 S114
2x55 I100 I96 I99 I96 I96 I100 I99 I115
2x551 L101 L97 L100 L97 L97 L101 L100 L116
2x56 V102 V98 V101 V98 V98 V102 V101 V117
2x57 M103 M99 M102 M99 M99 M103 M102 M118
2x58 P104 P100 P103 P100 P100 P104 P103 P119
2x59 I105 V101 I104 I101 I101 I105 I104 I120
2x60 S106 S102 S105 S102 S102 S106 S105 S121
2x61 T107 T103 T106 T103 T103 T107 T106 T122
2x62 M108 M104 M107 M104 M104 M108 M107 M123
2x63 Y109 Y105 Y108 Y105 Y105 Y109 Y108 Y124
2x64 T110 T106 T109 T106 T106 T110 T109 T125
2x65 V111 V107 V110 V107 V107 V111 V110 V126
2x66 T112 T108 T111 T108 T108 T112 T111 T127
2x67 G113 G109 G112 G109 G109 G113 G112 G128
ECL1
23x49 R114 R110 R113 R110 R110 R114 R113 R129
23x50 W115 W111 W114 W111 W111 W115 W114 W130
23x51 T116 T112 T115 T112 T112 T116 T115 T131
23x52 L117 L113 L116 L113 L113 L117 L116 L132
TM3
3x21 G118 G114 G117 G114 G114 G118 G117 G133
3x22 Q119 Q115 Q118 Q115 Q115 Q119 Q118 Q134
3x23 V120 V116 V119 V116 V116 V120 A119 V135
3x24 V121 V117 V120 V117 V117 V121 L120 V136
3x25 C122 C118 C121 C118 C118 C122 C121 C137
3x26 D123 D119 D122 D119 D119 D123 D122 D138
3x27 F124 F120 F123 F120 F120 F124 F123 L139
3x28 W125 W121 W124 W121 W121 W125 W124 W140
3x29 L126 L122 L125 L122 L122 L126 L125 L141
3x30 S127 S123 S126 S123 S123 S127 S126 S142
3x31 S128 S124 S127 S124 S124 S128 S127 S143
3x32 D129 D125 D128 D125 D125 D129 D128 D144
3x33 I130 I126 I129 I126 I126 I130 I129 I145
3x34 T131 T127 T130 T127 T127 T131 T130 T146
3x35 C132 C128 C131 C128 C128 C132 C131 C147
3x36 C133 C129 C132 C129 C129 C133 C132 C148
3x37 T134 T130 T133 T130 T130 T134 T133 T149
3x38 A135 A131 A134 A131 A131 A135 A134 A150
3x39 S136 S132 S135 S132 S132 S136 S135 S151
3x40 I137 I133 I136 I133 I133 I137 I136 I152
3x41 L138 M134 L137 M134 M134 L138 M137 L153
3x42 H139 H135 H138 H135 H135 H139 H138 H154
3x43 L140 L136 L139 L136 L136 L140 L139 L155
3x44 C141 C137 C140 C137 C137 C141 C140 C156
3x45 V142 V138 V141 V138 V138 V142 V141 V157
3x46 I143 I139 I142 I139 I139 I143 I142 I158
3x47 A144 A140 A143 A140 A140 A144 A143 A159
3x48 L145 L141 L144 L141 L141 L145 L144 L160
3x49 D146 D142 D145 D142 D142 D146 D145 D161
3x50 R147 R143 R146 R143 R143 R147 R146 R162
3x51 Y148 Y144 Y147 Y144 Y144 Y148 Y147 Y163
3x52 W149 W145 W148 W145 W145 W149 W148 W164
3x53 A150 A146 A149 A146 A146 A150 A149 A165
3x54 I151 I147 I150 I147 I147 I151 I150 I166
3x55 T152 T148 T151 T148 T148 T152 T151 T167
3x56 D153 D149 D152 D149 D149 D153 D152 D168
ICL2
34x50 A154 A150 A153 A150 A150 A154 A153 A169
34x51 V155 V151 V154 V151 V151 V155 V154 V170
34x52 E156 E152 E155 D152 E152 E156 G155 E171
34x53 Y157 Y153 Y156 Y153 Y153 Y157 Y156 Y172
34x54 S158 A154 S157 S154 S154 S158 S157 S173
34x55 A159 A155 A158 A155 A155 A159 A158 A174
34x56 K160 K156 K159 K156 K156 K160 K159 K175
34x57 R161 R157 R160 R157 R157 R161 R160 R176
TM4
4x38 T162 T158 T161 T158 T158 T162 T161 T177
4x39 P163 P159 P162 P159 P159 P163 P162 P178
4x40 K164 K160 K163 K160 K160 K164 R163 K179
4x41 R165 R161 R164 R161 R161 R165 R164 R180
4x42 A166 A162 A165 A162 A162 A166 A165 A181
4x43 A167 A163 A166 A163 A163 A167 A166 A182
4x44 V168 I164 V167 I164 I164 V168 G167 V183
4x45 M169 M165 M168 M165 M165 M169 M168 M184
4x46 I170 I166 I169 I166 I166 I170 I169 I185
4x47 A171 A167 A170 V167 V167 A171 A170 A186
4x48 L172 L168 L171 L168 L168 L172 L171 L187
4x49 V173 V169 V172 V169 V169 V173 V172 V188
4x50 W174 W170 W173 W170 W170 W174 W173 W189
4x51 V175 V171 V174 V171 V171 V175 V174 V190
4x52 F176 F172 F175 F172 F172 F176 F175 F191
4x53 S177 S173 S176 S173 S173 S177 S176 S192
4x54 I178 I174 I177 I174 I174 I178 I177 I193
4x55 S179 S175 S178 S175 S175 S179 C178 C194
4x56 I180 I176 I179 I176 I176 I180 I179 I195
4x57 S181 S177 S180 S177 S177 S181 S180 S196
4x58 L182 L178 L181 L178 L178 L182 L181 L197
4x59 P183 P179 P182 P179 P179 P183 P182 P198
4x60 P184 P180 P183 P180 P180 P184 P183 P199
4x61 F185 F181 F184 F181 F181 F185 F184 F200
4x62 F186 F182 F185 F182 F182 F186 F185 F201
4x63 W187 W183 W186 W183 W183 W187 W186 W202
ECL2
45x50 C199 C195 C198 C195 C195 C199 C198 C213
45x51 V200 L196 R199 F196 F196 V200 L199 V214
45x52 V201 V197 V200 V197 V197 V201 V200 V215
TM5
5x36 H205 H201 H204 H201 H201 H205 H204 H219
5x37 I206 V202 M205 V202 V202 I206 V205 V220
5x38 L207 L203 L206 L203 L203 L207 L206 L221
5x39 Y208 Y204 Y207 Y204 Y204 Y208 Y207 Y222
5x40 T209 T205 T208 T205 T205 T209 T208 T223
5x41 V210 V206 V209 V206 V206 V210 V209 V224
5x42 Y211 Y207 Y210 Y207 Y207 Y211 Y210 Y225
5x43 S212 S208 S211 S208 S208 S212 S211 S226
5x44 T213 T209 T212 T209 T209 T213 T212 T227
5x45 V214 G210 V213 V210 V210 V214 G213 V228
5x46 G215 G211 G214 G211 G211 G215 G214 G229
5x461 A216 A212 A215 A212 A212 A216 A215 A230
5x47 F217 F213 F216 F213 F213 F217 F216 F231
5x48 Y218 Y214 Y217 Y214 Y214 Y218 Y217 Y232
5x49 F219 L215 F218 L215 L215 F219 L218 F233
5x50 P220 P216 P219 P216 P216 P220 P219 P234
5x51 T221 T217 T220 T217 T217 T221 T220 T235
5x52 L222 L218 L221 L218 L218 L222 L221 L236
5x53 L223 L219 L222 L219 L219 L223 L222 L237
5x54 L224 L220 L223 L220 L220 L224 L223 L238
5x55 I225 I221 I224 I221 I221 I225 I224 I239
5x56 A226 A222 A225 A222 A222 A226 A225 A240
5x57 L227 L223 L226 L223 L223 L227 L226 L241
5x58 Y228 Y224 Y227 Y224 Y224 Y228 Y227 Y242
5x59 G229 G225 G228 G225 G225 G229 G228 G243
5x60 R230 R226 R229 R226 R226 R230 R229 R244
5x61 I231 I227 I230 I227 I227 I231 I230 I245
5x62 Y232 Y228 Y231 Y228 Y228 Y232 Y231 Y246
5x63 V233 V229 V232 V229 V229 V233 V232 V247
5x64 E234 E230 E233 E230 E230 E234 E233 E248
5x65 A235 A231 A234 A231 A231 A235 A234 A249
5x66 R236 R232 R235 R232 R232 R236 R235 R250
5x67 S237 S233 S236 S233 S233 S237 S236 S251
5x68 R238 R234 R237 R234 R234 R238 R237 R252
5x69 I239 I235 I238 I235 I235 I239 I238 I253
5x70 L240 L236 L239 L236 L236 L240 L239 L254
5x71 K241 K237 K240 K237 K237 K241 K240 K255
5x72 Q242 Q238 Q241 Q238 Q238 Q242 Q241 Q256
5x73 T243 T239 T242 T239 T239 T243 T242 T257
5x74 P244 P240 P243 P240 P240 P244 P243 P258
TM6
6x24 K303 K299 K302 K299 K299 K303 K302 K317
6x25 L304 L300 L303 L300 L300 L304 L303 L318
6x26 M305 M301 M304 M301 M301 M305 M304 M319
6x27 A306 A302 A305 A302 A302 A306 A305 A320
6x28 A307 A303 A306 A303 A303 A307 A306 A321
6x29 R308 R304 R307 R304 R304 R308 R307 R322
6x30 E309 E305 E308 E305 E305 E309 E308 E323
6x31 R310 R306 R309 R306 R306 R310 R309 R324
6x32 K311 K307 K310 K307 K307 K311 K310 K325
6x33 A312 A308 A311 A308 A308 A312 A311 A326
6x34 T313 T309 T312 T309 T309 T313 T312 T327
6x35 K314 K310 K313 K310 K310 K314 K313 K328
6x36 T315 T311 T314 T311 T311 T315 T314 T329
6x37 L316 L312 L315 L312 L312 L316 L315 L330
6x38 G317 G313 G316 G313 G313 G317 G316 G331
6x39 I318 I314 I317 I314 I314 I318 V317 I332
6x40 I319 I315 I318 I315 I315 I319 I318 I333
6x41 L320 L316 L319 L316 L316 L320 L319 L334
6x42 G321 G317 G320 G317 G317 G321 G320 G335
6x43 A322 A318 A321 A318 A318 A322 A321 A336
6x44 F323 F319 F322 F319 F319 F323 F322 F337
6x45 I324 I320 I323 I320 I320 I324 I323 I338
6x46 V325 V321 V324 V321 V321 V325 V324 V339
6x47 C326 C322 C325 C322 C322 C326 C325 C340
6x48 W327 W323 W326 W323 W323 W327 W326 W341
6x49 L328 L324 L327 L324 L324 L328 L327 L342
6x50 P329 P325 P328 P325 P325 P329 P328 P343
6x51 F330 F326 F329 F326 F326 F330 F329 F344
6x52 F331 F327 F330 F327 F327 F331 F330 F345
6x53 I332 I328 I331 I328 I328 I332 I331 I346
6x54 I333 I329 I332 I329 I329 I333 I332 I347
6x55 S334 S330 S333 S330 S330 S334 S333 S348
6x56 L335 L331 L334 L331 L331 L335 L334 L349
6x57 V336 V332 V335 V332 V332 V336 V335 A350
6x58 M337 M333 M336 M333 M333 M337 M336 I351
6x59 P338 P334 P337 P334 P334 P338 P337 P352
6x60 I339 I335 I338 I335 I335 I339 I338 I353
6x61 C340 C336 C339 C336 C336 C340 C339 C354
TM7
7x30 H347 H343 H346 H343 H343 H347 H346 H360
7x31 L348 M344 L347 M344 M344 L348 M347 Q361
7x32 A349 A345 A348 A345 A345 A349 A348 A362
7x33 I350 T346 I349 I346 I346 I350 I349 I363
7x34 F351 L347 F350 F347 F347 F351 F350 F364
7x35 D352 D348 D351 D348 D348 D352 D351 D365
7x36 F353 F349 F352 F349 F349 F353 F352 F366
7x37 F354 F350 F353 F350 F350 F354 F353 F367
7x38 T355 N351 T354 N351 N351 T355 T354 T368
7x39 W356 W352 W355 W352 W352 W356 W355 W369
7x40 L357 L353 L356 L353 L353 L357 L356 L370
7x41 G358 G354 G357 G354 G354 G358 G357 G371
7x42 Y359 Y355 Y358 Y355 Y355 Y359 Y358 Y372
7x43 L360 L356 L359 L356 L356 L360 L359 L373
7x45 N361 N357 N360 N357 N357 N361 N360 N374
7x46 S362 S358 S361 S358 S358 S362 S361 S375
7x47 L363 L359 L362 L359 L359 L363 L362 L376
7x48 I364 I360 I363 I360 I360 I364 I363 I377
7x49 N365 N361 N364 N361 N361 N365 N364 N378
7x50 P366 P362 P365 P362 P362 P366 P365 P379
7x51 I367 I363 I366 I363 I363 I367 I366 I380
7x52 I368 I364 I367 I364 I364 I368 I367 I381
7x53 Y369 Y365 Y368 Y365 Y365 Y369 Y368 Y382
7x54 T370 T366 T369 T366 T366 T370 T369 T383
7x55 M371 M367 M370 M367 M367 M371 M370 M384
7x56 S372 S368 S371 S368 S368 S372 S371 S385
H8
8x47 N373 N369 N372 N369 N369 N373 N372 N386
8x48 E374 E370 E373 E370 E370 E374 E373 E387
8x49 D375 D371 D374 D371 D371 D375 D374 D388
8x50 F376 F372 F375 F372 F372 F376 F375 F389
8x51 K377 K373 K376 K373 K373 K377 K376 K390
8x52 Q378 Q374 Q377 Q374 Q374 Q378 Q377 Q391
8x53 A379 A375 A378 A375 A375 A379 A378 A392
8x54 F380 F376 F379 F376 F376 F380 F379 F393
8x55 H381 H377 H380 H377 H377 H381 H380 H394
8x56 K382 K378 K381 K378 K378 K382 K381 K395
8x57 L383 L379 L382 L379 L379 L383 L382 L396
8x58 I384 I380 I383 I380 I380 I384 I383 I397