NK2 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

B

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.7 Å

REFERENCE

PUBLICATION DATE

May 31, 2023

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

HIS-LYS-THR-ASP-SER-PHE-VAL-GLY-LEU-MET-NH2 - Agonist

ENDOGENOUS LIGANDS

neurokinin B, neuropeptide γ, hemokinin 1, neurokinin A, substance P, neuropeptide K



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic ICL2 F 139 - G.S3 V 194 G.S3.01
Van-der-waals ICL2 F 139 - G.S3 V 194 G.S3.01
Polar ICL2 L 143 - G.hns1 R 31 G.hns1.02
Ionic ICL3 R 227 - G.H5 D 348 G.H5.13
Polar ICL3 R 227 - G.H5 D 348 G.H5.13
Hydrophobic TM5 L 224 5x65 G.H5 L 355 G.H5.20
Hydrophobic TM3 A 134 3x53 G.H5 Y 358 G.H5.23
Van-der-waals TM3 A 134 3x53 G.H5 Y 358 G.H5.23
Hydrophobic TM3 I 135 3x54 G.H5 N 354 G.H5.19
Hydrophobic C-term N 311 - G.H5 N 359 G.H5.24
Van-der-waals C-term N 311 - G.H5 N 359 G.H5.24
Hydrophobic TM2 T 68 2x39 G.H5 Y 358 G.H5.23
Van-der-waals TM2 T 68 2x39 G.H5 Y 358 G.H5.23
Hydrophobic ICL2 P 138 - G.H5 I 350 G.H5.15
Van-der-waals ICL2 P 138 - G.H5 I 350 G.H5.15
Hydrophobic TM3 R 131 3x50 G.H5 Y 358 G.H5.23
Van-der-waals TM3 R 131 3x50 G.H5 Y 358 G.H5.23
Hydrophobic ICL2 F 139 - G.H5 K 347 G.H5.12
Van-der-waals ICL2 F 139 - G.H5 K 347 G.H5.12
Hydrophobic TM6 A 244 6x29 G.H5 V 361 G.H5.26
Van-der-waals TM6 A 244 6x29 G.H5 V 361 G.H5.26
Hydrophobic TM6 M 252 6x37 G.H5 L 360 G.H5.25
Aromatic ICL2 F 139 - G.H5 F 343 G.H5.08
Hydrophobic ICL2 F 139 - G.H5 F 343 G.H5.08
Van-der-waals ICL2 F 139 - G.H5 F 343 G.H5.08
Van-der-waals ICL3 R 227 - G.H5 Q 352 G.H5.17
Hydrophobic TM3 I 135 3x54 G.H5 L 355 G.H5.20
Van-der-waals TM3 I 135 3x54 G.H5 L 355 G.H5.20
Polar TM3 A 134 3x53 G.H5 N 354 G.H5.19
Hydrophobic TM3 A 134 3x53 G.H5 N 354 G.H5.19
Van-der-waals TM3 A 134 3x53 G.H5 N 354 G.H5.19
Hydrophobic TM3 R 131 3x50 G.H5 L 360 G.H5.25
Hydrophobic TM5 T 223 5x64 G.H5 L 351 G.H5.16
Hydrophobic ICL2 F 139 - G.H5 C 346 G.H5.11
Van-der-waals ICL2 F 139 - G.H5 C 346 G.H5.11
Hydrophobic TM6 F 248 6x33 G.H5 L 360 G.H5.25
Hydrophobic ICL2 F 139 - G.S1 L 34 G.S1.02
Van-der-waals ICL2 F 139 - G.S1 L 34 G.S1.02
Hydrophobic ICL2 P 141 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 P 141 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 P 138 - G.H5 K 347 G.H5.12
Hydrophobic ICL2 F 139 - G.H5 I 350 G.H5.15
Polar C-term L 310 - G.H5 N 359 G.H5.24
Hydrophobic C-term L 310 - G.H5 N 359 G.H5.24
Van-der-waals C-term L 310 - G.H5 N 359 G.H5.24
Polar TM3 D 130 3x49 G.H5 Y 358 G.H5.23
Hydrophobic TM3 D 130 3x49 G.H5 Y 358 G.H5.23
Van-der-waals TM3 D 130 3x49 G.H5 Y 358 G.H5.23
Hydrophobic ICL3 R 227 - G.H5 L 351 G.H5.16
Hydrophobic TM3 I 135 3x54 G.H5 L 351 G.H5.16