GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

ARRESTIN (FAMILY)

Beta

ARRESTIN

ARRESTIN SPECIES

Human

ARRESTIN CHAIN

A

ARRESTIN COVERAGE

79

PDB CODE

RESOLUTION

3.2 Å

REFERENCE

PUBLICATION DATE

Nov. 19, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

Chemerin - Agonist

PHYSIOLOGICAL LIGANDS

chemerin (Human)



GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Arrestin
segment

AA

Number
Generic
number
Hydrophobic ICL3 I 238 - S6 K 77 N.S6.03
Van-der-waals ICL3 I 238 - S6 K 77 N.S6.03
Hydrophobic TM7 I 307 7x56 s5s6 D 69 N.s5s6.06
Van-der-waals TM7 I 307 7x56 s5s6 D 69 N.s5s6.06
Hydrophobic TM3 L 139 3x54 s15s16 F 244 C.s15s16.03
Van-der-waals TM3 L 139 3x54 s15s16 F 244 C.s15s16.03
Hydrophobic TM2 T 72 2x39 s5s6 V 70 N.s5s6.07
Hydrophobic C-term L 1365 - H1 K 107 N.H1.09
Hydrophobic TM3 H 138 3x53 S6 F 75 N.S6.01
Hydrophobic TM7 Y 304 7x53 s5s6 L 71 N.s5s6.08
Van-der-waals TM7 Y 304 7x53 s5s6 L 71 N.s5s6.08
Polar TM3 H 141 3x56 S5 Y 63 N.S5.12
Hydrophobic TM6 T 247 6x36 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 T 247 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic C-term L 1365 - H1 R 103 N.H1.05
Van-der-waals C-term L 1365 - H1 R 103 N.H1.05
Hydrophobic ICL3 I 238 - s15s16 L 243 C.s15s16.02
Hydrophobic TM2 T 72 2x39 s5s6 L 68 N.s5s6.05
Hydrophobic TM3 H 135 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic TM6 R 243 6x32 s5s6 G 72 N.s5s6.09
Polar TM3 H 141 3x56 S16 Y 249 C.S16.03
Hydrophobic TM3 L 139 3x54 s5s6 L 73 N.s5s6.10
Van-der-waals TM3 L 139 3x54 s5s6 L 73 N.s5s6.10
Hydrophobic ICL3 I 238 - s15s16 F 244 C.s15s16.03
Van-der-waals ICL3 I 238 - s15s16 F 244 C.s15s16.03
Hydrophobic TM6 I 248 6x37 s5s6 L 71 N.s5s6.08
Polar C-term A 1366 - H1 R 103 N.H1.05
Hydrophobic C-term A 1366 - H1 R 103 N.H1.05
Van-der-waals C-term A 1366 - H1 R 103 N.H1.05
Polar H8 K 309 8x48 s5s6 D 69 N.s5s6.06
Hydrophobic H8 K 309 8x48 s5s6 D 69 N.s5s6.06
Van-der-waals H8 K 309 8x48 s5s6 D 69 N.s5s6.06
Hydrophobic TM3 H 135 3x50 s5s6 L 73 N.s5s6.10
Van-der-waals TM3 H 135 3x50 s5s6 L 73 N.s5s6.10
Hydrophobic TM3 H 135 3x50 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 H 135 3x50 s5s6 L 71 N.s5s6.08
Hydrophobic TM2 F 76 2x43 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 F 76 2x43 s5s6 V 70 N.s5s6.07
Polar H8 S 308 8x47 s5s6 D 69 N.s5s6.06
Hydrophobic C-term L 1365 - S1 V 8 N.S1.01
Van-der-waals C-term L 1365 - S1 V 8 N.S1.01
Hydrophobic TM3 I 140 3x55 s15s16 N 245 C.s15s16.04
Hydrophobic ICL3 L 239 - s15s16 F 244 C.s15s16.03
Polar TM6 H 244 6x33 s5s6 G 72 N.s5s6.09
Hydrophobic TM6 H 244 6x33 s5s6 G 72 N.s5s6.09
Van-der-waals TM6 H 244 6x33 s5s6 G 72 N.s5s6.09
Hydrophobic C-term L 1365 - ns1 T 6 N.ns1.14
Van-der-waals C-term L 1365 - ns1 T 6 N.ns1.14
Polar ICL2 P 142 - S16 Y 249 C.S16.03
Hydrophobic ICL2 P 142 - S16 Y 249 C.S16.03
Van-der-waals ICL2 P 142 - S16 Y 249 C.S16.03
Hydrophobic C-term L 1365 - H1 L 100 N.H1.02
Hydrophobic TM7 I 307 7x56 s5s6 L 71 N.s5s6.08
Hydrophobic TM7 I 307 7x56 s5s6 G 72 N.s5s6.09
Van-der-waals TM7 I 307 7x56 s5s6 G 72 N.s5s6.09
Hydrophobic ICL2 V 143 - S16 Y 249 C.S16.03
Polar TM6 H 244 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 H 244 6x33 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 H 244 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 I 140 3x55 s15s16 F 244 C.s15s16.03
Ionic ICL1 K 68 - s5s6 E 66 N.s5s6.03
Polar ICL1 K 68 - s5s6 E 66 N.s5s6.03
Hydrophobic ICL1 K 68 - s5s6 E 66 N.s5s6.03
Van-der-waals ICL1 K 68 - s5s6 E 66 N.s5s6.03