μ receptor - Beta-arrestin-1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Mus musculus

GPCR PREFERRED CHAIN

R

ARRESTIN (FAMILY)

Beta

ARRESTIN

Beta-arrestin-1

ARRESTIN SPECIES

Bovine

ARRESTIN CHAIN

C

ARRESTIN COVERAGE

84

PDB CODE

9WSV

RESOLUTION

2.8 Å

REFERENCE

10.1038/S41422-025-01191-8

PUBLICATION DATE

Nov. 26, 2025

3D VIEW

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LIGAND INTERACTIONS

28 interactions (Click to see)

LIGANDS

DAMGO - Agonist pubchem gtoplig chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic H8 E 341 8x48 s5s6 G 72 N.s5s6.09
Van-der-waals H8 E 341 8x48 s5s6 G 72 N.s5s6.09
Hydrophobic ICL2 V 173 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 V 173 34x51 S15 I 241 C.S15.14
Hydrophobic TM3 A 168 3x53 S6 F 75 N.S6.01
Van-der-waals TM3 A 168 3x53 S6 F 75 N.S6.01
Polar TM4 T 180 4x38 s17s18 R 285 C.s17s18.11
Van-der-waals TM4 T 180 4x38 s17s18 R 285 C.s17s18.11
Hydrophobic ICL2 R 179 34x57 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 L 176 34x54 S5 Y 63 N.S5.12
Van-der-waals ICL2 L 176 34x54 S5 Y 63 N.S5.12
Hydrophobic TM3 V 169 3x54 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 V 169 3x54 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 R 165 3x50 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 R 165 3x50 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 L 176 34x54 S8 L 129 N.S8.03
Hydrophobic TM2 T 103 2x39 s5s6 D 69 N.s5s6.06
Van-der-waals TM2 T 103 2x39 s5s6 D 69 N.s5s6.06
Hydrophobic TM6 M 281 6x36 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 M 281 6x36 s5s6 L 71 N.s5s6.08
Polar TM6 R 277 6x32 s5s6 G 72 N.s5s6.09
Hydrophobic TM5 S 261 5x67 s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 V 173 34x51 S16 A 247 C.S16.01
Hydrophobic ICL2 L 176 34x54 s5s6 G 64 N.s5s6.01
Hydrophobic ICL2 L 176 34x54 S9 C 140 N.S9.01
Van-der-waals ICL2 L 176 34x54 S9 C 140 N.S9.01
Polar TM6 R 277 6x32 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 R 277 6x32 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 I 278 6x33 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 I 278 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 A 168 3x53 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 A 168 3x53 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 D 177 34x55 s17s18 R 285 C.s17s18.11
Polar TM5 R 258 5x64 s15s16 F 244 C.s15s16.03
Hydrophobic TM5 R 258 5x64 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 R 258 5x64 s15s16 F 244 C.s15s16.03
Hydrophobic C-term K 374 - H1 R 103 N.H1.05
Van-der-waals C-term K 374 - H1 R 103 N.H1.05
Hydrophobic ICL2 P 172 34x50 s15s16 L 243 C.s15s16.02
Hydrophobic TM5 M 255 5x61 s5s6 L 71 N.s5s6.08
Van-der-waals TM5 M 255 5x61 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 P 172 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 P 172 34x50 S5 Y 63 N.S5.12