PDB
9WSV
Resolution
2.8 Å
Released
Nov. 26, 2025
Receptor
μ
Class
A
Species
Mus musculus
Ligand
Function
DAMGO
Agonist
Reference
10.1038/S41422-025-01191-8

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Ligand Amino Acid Generic Number Segment Interaction Type
DAMGO Q124 2.60x60 TM2 Van der Waals
DAMGO N127 2.63x63 TM2 Van der Waals
DAMGO V143 3.28x28 TM3 hydrophobic
DAMGO I144 3.29x29 TM3 hydrophobic
DAMGO D147 3.32x32 TM3 polar (charge-charge)
DAMGO Y148 3.33x33 TM3 hydrophobic
DAMGO M151 3.36x36 TM3 hydrophobic
DAMGO C217 45.50x50 ECL2 hydrophobic
DAMGO T218 45.51x51 ECL2 Van der Waals
DAMGO V236 5.42x43 TM5 Van der Waals
DAMGO W293 6.48x48 TM6 Van der Waals
DAMGO I296 6.51x51 TM6 hydrophobic
DAMGO H297 6.52x52 TM6 Van der Waals
DAMGO V300 6.55x55 TM6 hydrophobic
DAMGO W318 7.35x34 TM7 hydrophobic
DAMGO I322 7.39x38 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A G P G N I S D C S D P L A P A S C S P A P G S W L N L S H V D G N Q S D P C G P N R T G L G G S H S L C P Q T G S P S N-termC-term P T S S T I E Q Q N S A R I R Q N T R E H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M V T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G N I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I V N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L I T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
Helix box plot — Download: PNG | SVG F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I V N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7

GPCRdb(A)
GPCRdb(A)
μ receptor
TM2
2x60 2.60x60 Q124
2x63 2.63x63 N127
TM3
3x28 3.28x28 V143
3x29 3.29x29 I144
3x32 3.32x32 D147
3x33 3.33x33 Y148
3x36 3.36x36 M151
ECL2
45x50 45.50x50 C217
45x51 45.51x51 T218
TM5
5x43 5.42x43 V236
TM6
6x48 6.48x48 W293
6x51 6.51x51 I296
6x52 6.52x52 H297
6x55 6.55x55 V300
TM7
7x34 7.35x34 W318
7x38 7.39x38 I322