μ receptor - Gz

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Mus musculus

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9WSW

RESOLUTION

2.8 Å

REFERENCE

10.1038/S41422-025-01191-8

PUBLICATION DATE

Nov. 26, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

44 interactions (Click to see)

LIGANDS

endomorphin-1 (Human) - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 M 264 - G.h4s6 E 315 G.h4s6.08
Hydrophobic H8 N 342 8x49 G.H5 G 352 G.H5.23
Hydrophobic ICL3 M 264 - G.h4s6 K 317 G.h4s6.10
Hydrophobic ICL2 V 173 34x51 G.s2s3 E 193 G.s2s3.01
Polar TM2 T 103 2x39 G.H5 I 351 G.H5.22
Hydrophobic TM2 T 103 2x39 G.H5 I 351 G.H5.22
Hydrophobic ICL3 M 264 - G.h4s6 E 318 G.h4s6.11
Van-der-waals ICL3 M 264 - G.h4s6 E 318 G.h4s6.11
Hydrophobic TM3 R 165 3x50 G.H5 I 351 G.H5.22
Hydrophobic TM6 I 278 6x33 G.H5 C 354 G.H5.25
Van-der-waals TM6 I 278 6x33 G.H5 C 354 G.H5.25
Hydrophobic TM6 I 278 6x33 G.H5 L 353 G.H5.24
Hydrophobic H8 D 340 8x47 G.H5 G 352 G.H5.23
Van-der-waals H8 D 340 8x47 G.H5 G 352 G.H5.23
Ionic TM6 K 271 6x26 G.h4s6 E 318 G.h4s6.11
Polar TM6 K 271 6x26 G.h4s6 E 318 G.h4s6.11
Hydrophobic TM5 M 255 5x61 G.H5 L 353 G.H5.24
Van-der-waals TM5 M 255 5x61 G.H5 L 353 G.H5.24
Hydrophobic ICL3 M 264 - G.h4s6 T 316 G.h4s6.09
Hydrophobic TM5 R 258 5x64 G.H5 I 344 G.H5.15
Van-der-waals TM5 R 258 5x64 G.H5 I 344 G.H5.15
Hydrophobic TM3 A 168 3x53 G.H5 I 351 G.H5.22
Van-der-waals TM3 A 168 3x53 G.H5 I 351 G.H5.22
Polar H8 R 345 8x52 G.H5 C 354 G.H5.25
Polar TM6 R 277 6x32 G.H5 C 354 G.H5.25
Polar TM6 K 271 6x26 G.h4s6 K 314 G.h4s6.04
Hydrophobic TM5 L 259 5x65 G.H5 L 348 G.H5.19
Van-der-waals TM5 L 259 5x65 G.H5 L 348 G.H5.19
Hydrophobic ICL3 M 264 - G.H5 Q 345 G.H5.16
Van-der-waals ICL3 M 264 - G.H5 Q 345 G.H5.16
Ionic ICL2 K 174 34x52 G.s2s3 E 193 G.s2s3.01
Polar ICL2 K 174 34x52 G.s2s3 E 193 G.s2s3.01
Van-der-waals ICL2 K 174 34x52 G.s2s3 E 193 G.s2s3.01
Hydrophobic ICL2 P 172 34x50 G.H5 T 340 G.H5.11
Polar TM6 R 277 6x32 G.H5 L 353 G.H5.24
Van-der-waals TM6 R 277 6x32 G.H5 L 353 G.H5.24
Polar TM3 A 168 3x53 G.H5 N 347 G.H5.18
Hydrophobic TM3 A 168 3x53 G.H5 N 347 G.H5.18
Van-der-waals TM3 A 168 3x53 G.H5 N 347 G.H5.18
Hydrophobic TM3 V 169 3x54 G.H5 I 351 G.H5.22
Hydrophobic ICL2 P 172 34x50 G.H5 I 343 G.H5.14
Van-der-waals ICL2 P 172 34x50 G.H5 I 343 G.H5.14
Hydrophobic ICL2 L 176 34x54 G.s2s3 L 194 G.s2s3.02
Hydrophobic TM3 V 169 3x54 G.H5 L 348 G.H5.19
Hydrophobic ICL2 V 173 34x51 G.H5 F 336 G.H5.07
Hydrophobic ICL2 V 173 34x51 G.s2s3 L 194 G.s2s3.02
Hydrophobic TM5 L 259 5x65 G.H5 I 344 G.H5.15
Hydrophobic ICL3 R 263 - G.S6 Y 320 G.S6.01
Van-der-waals ICL3 R 263 - G.S6 Y 320 G.S6.01
Hydrophobic ICL2 R 179 34x57 G.H5 I 351 G.H5.22
Polar TM6 S 268 6x23 G.h4s6 E 315 G.h4s6.08
Polar H8 E 341 8x48 G.H5 G 352 G.H5.23
Hydrophobic H8 E 341 8x48 G.H5 G 352 G.H5.23
Van-der-waals H8 E 341 8x48 G.H5 G 352 G.H5.23
Hydrophobic TM4 T 180 4x38 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 L 176 34x54 G.H5 I 343 G.H5.14
Hydrophobic ICL3 L 265 - G.H5 L 348 G.H5.19
Polar H8 N 342 8x49 G.H5 Y 350 G.H5.21
Van-der-waals H8 N 342 8x49 G.H5 Y 350 G.H5.21
Polar H8 N 342 8x49 G.H5 K 349 G.H5.20
Polar ICL2 L 176 34x54 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 L 176 34x54 G.hns1 R 31 G.hns1.02
Ionic TM5 R 258 5x64 G.H5 D 341 G.H5.12
Polar TM5 R 258 5x64 G.H5 D 341 G.H5.12
Hydrophobic TM5 V 262 5x68 G.H5 Q 345 G.H5.16
Hydrophobic TM3 R 165 3x50 G.H5 L 353 G.H5.24
Van-der-waals TM3 V 169 3x54 G.H5 I 344 G.H5.15
Hydrophobic TM5 V 262 5x68 G.H5 I 344 G.H5.15
Van-der-waals TM5 V 262 5x68 G.H5 I 344 G.H5.15
Hydrophobic TM2 T 103 2x39 G.H5 Y 350 G.H5.21
Van-der-waals TM2 T 103 2x39 G.H5 Y 350 G.H5.21
Ionic ICL3 R 263 - G.h4s6 E 318 G.h4s6.11
Polar ICL3 R 263 - G.h4s6 E 318 G.h4s6.11
Hydrophobic ICL3 R 263 - G.h4s6 E 318 G.h4s6.11
Polar H8 E 341 8x48 G.H5 C 354 G.H5.25
Hydrophobic H8 E 341 8x48 G.H5 C 354 G.H5.25
Van-der-waals H8 E 341 8x48 G.H5 C 354 G.H5.25
Hydrophobic ICL2 P 172 34x50 G.H5 I 344 G.H5.15
Van-der-waals ICL2 P 172 34x50 G.H5 I 344 G.H5.15
Hydrophobic TM6 E 270 6x25 G.h4s6 E 315 G.h4s6.08
Van-der-waals TM6 E 270 6x25 G.h4s6 E 315 G.h4s6.08
Polar H8 E 341 8x48 G.H5 L 353 G.H5.24
Hydrophobic H8 E 341 8x48 G.H5 L 353 G.H5.24
Van-der-waals H8 E 341 8x48 G.H5 L 353 G.H5.24