PDB
9WSW
Resolution
2.8 Å
Released
Nov. 26, 2025
Receptor
μ
Class
A
Species
Mus musculus
Ligand
endomorphin-1 (Human)
Function
Agonist
Reference
10.1038/S41422-025-01191-8

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Ligand Amino Acid Generic Number Segment Interaction Type
endomorphin-1 (Human) Y75 1.39x39 TM1 hydrophobic
endomorphin-1 (Human) N127 2.63x63 TM2 polar (hydrogen bond)
endomorphin-1 (Human) W133 23.50x50 ECL1 aromatic (face-to-edge)
endomorphin-1 (Human) W133 23.50x50 ECL1 Van der Waals
endomorphin-1 (Human) V143 3.28x28 TM3 Van der Waals
endomorphin-1 (Human) I144 3.29x29 TM3 hydrophobic
endomorphin-1 (Human) I144 3.29x29 TM3 Van der Waals
endomorphin-1 (Human) D147 3.32x32 TM3 polar (charge-assisted hydrogen bond)
endomorphin-1 (Human) Y148 3.33x33 TM3 hydrophobic
endomorphin-1 (Human) Y148 3.33x33 TM3 Van der Waals
endomorphin-1 (Human) M151 3.36x36 TM3 Van der Waals
endomorphin-1 (Human) C217 45.50x50 ECL2 Van der Waals
endomorphin-1 (Human) C217 45.50x50 ECL2 polar (hydrogen bond with backbone)
endomorphin-1 (Human) K233 5.39x40 TM5 Van der Waals
endomorphin-1 (Human) V236 5.42x43 TM5 hydrophobic
endomorphin-1 (Human) V236 5.42x43 TM5 Van der Waals
endomorphin-1 (Human) H297 6.52x52 TM6 Van der Waals
endomorphin-1 (Human) W318 7.35x34 TM7 Van der Waals
endomorphin-1 (Human) W318 7.35x34 TM7 hydrophobic
endomorphin-1 (Human) H319 7.36x35 TM7 Van der Waals
endomorphin-1 (Human) I322 7.39x38 TM7 Van der Waals
endomorphin-1 (Human) I322 7.39x38 TM7 hydrophobic

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ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A G P G N I S D C S D P L A P A S C S P A P G S W L N L S H V D G N Q S D P C G P N R T G L G G S H S L C P Q T G S P S N-termC-term P T S S T I E Q Q N S A R I R Q N T R E H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M V T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G N I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I V N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L I T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
Helix box plot — Download: PNG | SVG F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I V N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7

GPCRdb(A)
GPCRdb(A)
μ receptor
TM1
1x39 1.39x39 Y75
TM2
2x63 2.63x63 N127
ECL1
23x50 23.50x50 W133
TM3
3x28 3.28x28 V143
3x29 3.29x29 I144
3x32 3.32x32 D147
3x33 3.33x33 Y148
3x36 3.36x36 M151
ECL2
45x50 45.50x50 C217
TM5
5x40 5.39x40 K233
5x43 5.42x43 V236
TM6
6x52 6.52x52 H297
TM7
7x34 7.35x34 W318
7x35 7.36x35 H319
7x38 7.39x38 I322