GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 59.6
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.7
PAE mean: 16.7
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM5 | G | 1052 | 5x66 | G.H5 | A | 342 | G.H5.09 |
Van-der-waals | TM5 | G | 1052 | 5x66 | G.H5 | A | 342 | G.H5.09 |
Hydrophobic | ICL3 | K | 1059 | - | G.h4s6 | I | 323 | G.h4s6.20 |
Hydrophobic | TM3 | S | 966 | 3x54 | G.H5 | L | 358 | G.H5.25 |
Polar | TM2 | R | 910 | 2x46 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM2 | R | 910 | 2x46 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM2 | R | 910 | 2x46 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM5 | I | 1053 | 5x67 | G.H5 | F | 339 | G.H5.06 |
Van-der-waals | TM5 | I | 1053 | 5x67 | G.H5 | F | 339 | G.H5.06 |
Ionic | ICL3 | K | 1059 | - | G.H5 | D | 346 | G.H5.13 |
Polar | ICL3 | K | 1059 | - | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | ICL3 | K | 1059 | - | G.H5 | D | 346 | G.H5.13 |
Van-der-waals | ICL3 | K | 1059 | - | G.H5 | D | 346 | G.H5.13 |
Polar | C-term | E | 1189 | - | G.H3 | T | 257 | G.H3.11 |
Hydrophobic | C-term | E | 1189 | - | G.H3 | T | 257 | G.H3.11 |
Van-der-waals | C-term | E | 1189 | - | G.H3 | T | 257 | G.H3.11 |
Hydrophobic | ICL3 | M | 1065 | - | G.H4 | D | 315 | G.H4.17 |
Van-der-waals | ICL3 | M | 1065 | - | G.H4 | D | 315 | G.H4.17 |
Hydrophobic | ICL3 | M | 1065 | - | G.H4 | V | 314 | G.H4.16 |
Van-der-waals | ICL3 | M | 1065 | - | G.H4 | V | 314 | G.H4.16 |
Hydrophobic | TM3 | A | 969 | 3x57 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | ICL3 | A | 1062 | - | G.h4s6 | P | 318 | G.h4s6.09 |
Hydrophobic | TM5 | R | 1050 | 5x64 | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | TM5 | R | 1050 | 5x64 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | ICL3 | H | 1060 | - | G.H4 | L | 310 | G.H4.12 |
Hydrophobic | C-term | C | 1196 | - | G.H2 | I | 217 | G.H2.08 |
Van-der-waals | C-term | C | 1196 | - | G.H2 | I | 217 | G.H2.08 |
Polar | ICL3 | H | 1060 | - | G.S6 | S | 326 | G.S6.03 |
Hydrophobic | ICL3 | H | 1060 | - | G.S6 | S | 326 | G.S6.03 |
Van-der-waals | ICL3 | H | 1060 | - | G.S6 | S | 326 | G.S6.03 |
Hydrophobic | TM5 | G | 1052 | 5x66 | G.H5 | D | 346 | G.H5.13 |
Aromatic | C-term | W | 1503 | - | G.S2 | Y | 192 | G.S2.04 |
Hydrophobic | C-term | W | 1503 | - | G.S2 | Y | 192 | G.S2.04 |
Van-der-waals | C-term | W | 1503 | - | G.S2 | Y | 192 | G.S2.04 |
Aromatic | C-term | W | 1503 | - | G.H1 | R | 60 | G.H1.09 |
Hydrophobic | C-term | W | 1503 | - | G.H1 | R | 60 | G.H1.09 |
Van-der-waals | C-term | W | 1503 | - | G.H1 | R | 60 | G.H1.09 |
Hydrophobic | C-term | F | 1188 | - | G.H3 | L | 254 | G.H3.08 |
Van-der-waals | C-term | F | 1188 | - | G.H3 | L | 254 | G.H3.08 |
Polar | ICL3 | L | 1058 | - | G.S6 | S | 326 | G.S6.03 |
Van-der-waals | ICL3 | L | 1058 | - | G.S6 | S | 326 | G.S6.03 |
Hydrophobic | ICL3 | T | 1091 | - | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | ICL3 | T | 1091 | - | G.H5 | V | 359 | G.H5.26 |
Ionic | C-term | D | 1191 | - | G.H2 | R | 214 | G.H2.05 |
Polar | C-term | D | 1191 | - | G.H2 | R | 214 | G.H2.05 |
Hydrophobic | C-term | D | 1191 | - | G.H2 | R | 214 | G.H2.05 |
Van-der-waals | C-term | D | 1191 | - | G.H2 | R | 214 | G.H2.05 |
Hydrophobic | C-term | F | 1188 | - | G.H3 | I | 258 | G.H3.12 |
Van-der-waals | C-term | F | 1188 | - | G.H3 | I | 258 | G.H3.12 |
Polar | ICL3 | T | 1091 | - | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | ICL3 | T | 1091 | - | G.H5 | Q | 350 | G.H5.17 |
Van-der-waals | ICL3 | T | 1091 | - | G.H5 | Q | 350 | G.H5.17 |
Polar | ICL3 | K | 1057 | - | G.S6 | S | 326 | G.S6.03 |
Polar | H8 | E | 1153 | 8x49 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | H8 | E | 1153 | 8x49 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | H8 | E | 1153 | 8x49 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM6 | S | 1098 | 6x38 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | S | 1098 | 6x38 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | ICL3 | H | 1060 | - | G.h4s6 | I | 323 | G.h4s6.20 |
Hydrophobic | TM2 | R | 910 | 2x46 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM6 | N | 1094 | 6x34 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | N | 1094 | 6x34 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM5 | I | 1053 | 5x67 | G.S6 | Y | 325 | G.S6.02 |
Van-der-waals | TM5 | I | 1053 | 5x67 | G.S6 | Y | 325 | G.S6.02 |
Hydrophobic | ICL3 | K | 1059 | - | G.S6 | Y | 325 | G.S6.02 |
Hydrophobic | ICL3 | L | 1058 | - | G.S6 | Y | 325 | G.S6.02 |
Van-der-waals | ICL3 | L | 1058 | - | G.S6 | Y | 325 | G.S6.02 |
Hydrophobic | ICL3 | L | 1058 | - | G.H5 | F | 339 | G.H5.06 |
Hydrophobic | C-term | V | 1192 | - | G.H3 | Y | 261 | G.H3.15 |
Van-der-waals | C-term | V | 1192 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | TM3 | Q | 965 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | Q | 965 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Ionic | TM5 | D | 1051 | 5x65 | G.H5 | K | 345 | G.H5.12 |
Polar | TM5 | D | 1051 | 5x65 | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | TM5 | D | 1051 | 5x65 | G.H5 | K | 345 | G.H5.12 |
Van-der-waals | TM5 | D | 1051 | 5x65 | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | ICL3 | L | 1087 | - | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | TM5 | L | 1047 | 5x61 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | ICL2 | I | 974 | - | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | ICL2 | I | 974 | - | G.H5 | Y | 356 | G.H5.23 |
Polar | ICL2 | T | 976 | - | G.hns1 | R | 37 | G.hns1.02 |
Polar | ICL2 | R | 975 | - | G.HN | R | 34 | G.HN.52 |
Hydrophobic | ICL2 | R | 975 | - | G.HN | R | 34 | G.HN.52 |
Van-der-waals | ICL2 | R | 975 | - | G.HN | R | 34 | G.HN.52 |
Hydrophobic | ICL3 | T | 1091 | - | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | ICL3 | T | 1091 | - | G.H5 | L | 353 | G.H5.20 |
Polar | TM5 | I | 1053 | 5x67 | G.H5 | A | 342 | G.H5.09 |
Hydrophobic | TM5 | I | 1053 | 5x67 | G.H5 | A | 342 | G.H5.09 |
Polar | TM6 | A | 1095 | 6x35 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM6 | A | 1095 | 6x35 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | A | 1095 | 6x35 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | ICL3 | K | 1059 | - | G.S6 | I | 324 | G.S6.01 |
Hydrophobic | ICL3 | R | 1061 | - | G.h4s6 | I | 323 | G.h4s6.20 |
Hydrophobic | ICL3 | H | 1060 | - | G.H4 | V | 314 | G.H4.16 |
Van-der-waals | ICL3 | H | 1060 | - | G.H4 | V | 314 | G.H4.16 |
Hydrophobic | TM3 | V | 970 | 3x58 | G.H5 | L | 353 | G.H5.20 |
Ionic | C-term | R | 1431 | - | G.h2s4 | E | 221 | G.h2s4.02 |
Polar | C-term | R | 1431 | - | G.h2s4 | E | 221 | G.h2s4.02 |
Hydrophobic | C-term | R | 1431 | - | G.h2s4 | E | 221 | G.h2s4.02 |
Van-der-waals | C-term | R | 1431 | - | G.h2s4 | E | 221 | G.h2s4.02 |
Polar | C-term | F | 1188 | - | G.H3 | Y | 261 | G.H3.15 |
Aromatic | C-term | F | 1188 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | C-term | F | 1188 | - | G.H3 | Y | 261 | G.H3.15 |
Van-der-waals | C-term | F | 1188 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | C-term | F | 1188 | - | G.H3 | T | 257 | G.H3.11 |
Van-der-waals | C-term | F | 1188 | - | G.H3 | T | 257 | G.H3.11 |
Hydrophobic | C-term | F | 1188 | - | G.h2s4 | F | 220 | G.h2s4.01 |
Van-der-waals | C-term | F | 1188 | - | G.h2s4 | F | 220 | G.h2s4.01 |
Polar | C-term | R | 1431 | - | G.H2 | H | 218 | G.H2.09 |
Hydrophobic | ICL3 | R | 1061 | - | G.h4s6 | S | 320 | G.h4s6.11 |
Van-der-waals | ICL3 | R | 1061 | - | G.h4s6 | S | 320 | G.h4s6.11 |
Hydrophobic | TM3 | A | 969 | 3x57 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | A | 969 | 3x57 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL3 | A | 1062 | - | G.h4s6 | S | 320 | G.h4s6.11 |
Van-der-waals | ICL3 | A | 1062 | - | G.h4s6 | S | 320 | G.h4s6.11 |
Van-der-waals | TM3 | G | 972 | 3x60 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | C-term | T | 1186 | - | G.H3 | L | 254 | G.H3.08 |
Polar | C-term | T | 1186 | - | G.H3 | T | 257 | G.H3.11 |
Van-der-waals | C-term | T | 1186 | - | G.H3 | T | 257 | G.H3.11 |
Polar | H8 | R | 1151 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | H8 | R | 1151 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | H8 | R | 1151 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Polar | ICL3 | A | 1062 | - | G.h4s6 | D | 319 | G.h4s6.10 |
Hydrophobic | ICL3 | A | 1062 | - | G.h4s6 | D | 319 | G.h4s6.10 |
Van-der-waals | ICL3 | A | 1062 | - | G.h4s6 | D | 319 | G.h4s6.10 |
Polar | TM3 | A | 969 | 3x57 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | TM3 | A | 969 | 3x57 | G.H5 | N | 352 | G.H5.19 |
Van-der-waals | TM3 | A | 969 | 3x57 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | C-term | V | 1192 | - | G.H2 | I | 217 | G.H2.08 |
Polar | ICL3 | H | 1060 | - | G.S6 | I | 324 | G.S6.01 |
Hydrophobic | ICL3 | H | 1060 | - | G.S6 | I | 324 | G.S6.01 |
Van-der-waals | ICL3 | H | 1060 | - | G.S6 | I | 324 | G.S6.01 |
Ionic | C-term | D | 1187 | - | G.H2 | R | 210 | G.H2.01 |
Polar | C-term | D | 1187 | - | G.H2 | R | 210 | G.H2.01 |
Hydrophobic | C-term | D | 1187 | - | G.H2 | R | 210 | G.H2.01 |
Van-der-waals | C-term | D | 1187 | - | G.H2 | R | 210 | G.H2.01 |
Hydrophobic | ICL3 | A | 1062 | - | G.h4s6 | N | 317 | G.h4s6.08 |
Van-der-waals | ICL3 | A | 1062 | - | G.h4s6 | N | 317 | G.h4s6.08 |
Hydrophobic | C-term | T | 1186 | - | G.H3 | A | 253 | G.H3.07 |
Van-der-waals | C-term | T | 1186 | - | G.H3 | A | 253 | G.H3.07 |
Hydrophobic | TM5 | I | 1053 | 5x67 | G.H5 | A | 343 | G.H5.10 |
Van-der-waals | TM5 | I | 1053 | 5x67 | G.H5 | A | 343 | G.H5.10 |
Hydrophobic | ICL3 | M | 1065 | - | G.H4 | K | 311 | G.H4.13 |
Van-der-waals | ICL3 | M | 1065 | - | G.H4 | K | 311 | G.H4.13 |
Hydrophobic | C-term | A | 1195 | - | G.H2 | I | 217 | G.H2.08 |
Hydrophobic | H8 | R | 1152 | 8x48 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | H8 | R | 1152 | 8x48 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | ICL2 | I | 974 | - | G.H5 | N | 352 | G.H5.19 |
Van-der-waals | ICL2 | I | 974 | - | G.H5 | N | 352 | G.H5.19 |
Polar | TM2 | R | 910 | 2x46 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM2 | R | 910 | 2x46 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM2 | R | 910 | 2x46 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | C-term | F | 1188 | - | G.H2 | R | 213 | G.H2.04 |
Van-der-waals | C-term | F | 1188 | - | G.H2 | R | 213 | G.H2.04 |
Ionic | C-term | K | 1505 | - | H.HA | E | 70 | H.HA.02 |
Polar | C-term | K | 1505 | - | H.HA | E | 70 | H.HA.02 |
Van-der-waals | C-term | K | 1505 | - | H.HA | E | 70 | H.HA.02 |
Hydrophobic | TM6 | N | 1094 | 6x34 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM6 | N | 1094 | 6x34 | G.H5 | V | 359 | G.H5.26 |
Polar | C-term | R | 1431 | - | G.H2 | I | 217 | G.H2.08 |
Aromatic | C-term | F | 1188 | - | G.H2 | W | 216 | G.H2.07 |
Hydrophobic | C-term | F | 1188 | - | G.H2 | W | 216 | G.H2.07 |
Hydrophobic | TM6 | A | 1095 | 6x35 | G.H5 | L | 353 | G.H5.20 |