GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 83.6
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 17.4
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL3 | S | 375 | - | G.H5 | Q | 372 | G.H5.17 |
Van-der-waals | ICL3 | S | 375 | - | G.H5 | Q | 372 | G.H5.17 |
Hydrophobic | H8 | R | 440 | 8x48 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | H8 | R | 440 | 8x48 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | TM5 | L | 363 | 5x61 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | ICL2 | A | 288 | - | G.S1 | L | 57 | G.S1.01 |
Hydrophobic | TM5 | L | 370 | 5x68 | G.H5 | L | 371 | G.H5.16 |
Van-der-waals | TM5 | L | 370 | 5x68 | G.H5 | L | 371 | G.H5.16 |
Polar | ICL2 | T | 291 | - | G.H5 | N | 374 | G.H5.19 |
Polar | ICL2 | N | 289 | - | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | ICL2 | N | 289 | - | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | ICL2 | N | 289 | - | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | ICL3 | V | 374 | - | G.h4s6 | P | 345 | G.h4s6.20 |
Van-der-waals | ICL3 | V | 374 | - | G.h4s6 | P | 345 | G.h4s6.20 |
Polar | ICL2 | L | 285 | - | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | ICL2 | L | 285 | - | G.H5 | N | 374 | G.H5.19 |
Van-der-waals | ICL2 | L | 285 | - | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | TM3 | V | 282 | 3x58 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | V | 282 | 3x58 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | ICL2 | A | 288 | - | G.hns1 | R | 56 | G.hns1.03 |
Polar | ICL3 | T | 376 | - | G.H5 | Q | 372 | G.H5.17 |
Van-der-waals | ICL3 | T | 376 | - | G.H5 | Q | 372 | G.H5.17 |
Hydrophobic | ICL3 | I | 377 | - | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | ICL3 | I | 377 | - | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM3 | T | 281 | 3x57 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | T | 281 | 3x57 | G.H5 | I | 378 | G.H5.23 |
Polar | ICL2 | T | 293 | - | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | ICL2 | T | 293 | - | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | ICL2 | T | 293 | - | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | ICL3 | T | 376 | - | G.h4s6 | K | 344 | G.h4s6.19 |
Van-der-waals | ICL3 | T | 376 | - | G.h4s6 | K | 344 | G.h4s6.19 |
Hydrophobic | ICL2 | A | 288 | - | G.S1 | V | 58 | G.S1.02 |
Hydrophobic | TM5 | L | 370 | 5x68 | G.H5 | Q | 372 | G.H5.17 |
Hydrophobic | ICL2 | L | 285 | - | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | ICL2 | L | 285 | - | G.H5 | L | 375 | G.H5.20 |
Polar | ICL3 | V | 374 | - | G.H5 | Q | 372 | G.H5.17 |
Van-der-waals | ICL3 | V | 374 | - | G.H5 | Q | 372 | G.H5.17 |
Hydrophobic | ICL3 | T | 376 | - | G.h4s6 | S | 343 | G.h4s6.12 |
Polar | H8 | R | 440 | 8x48 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM5 | L | 367 | 5x65 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | ICL2 | A | 288 | - | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | ICL2 | R | 295 | - | G.HN | R | 52 | G.HN.52 |
Van-der-waals | ICL2 | R | 295 | - | G.HN | R | 52 | G.HN.52 |
Hydrophobic | ICL3 | V | 374 | - | G.S6 | L | 346 | G.S6.01 |
Hydrophobic | ICL2 | R | 295 | - | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | ICL2 | R | 295 | - | G.hns1 | R | 55 | G.hns1.02 |
Polar | ICL3 | T | 376 | - | G.H5 | K | 376 | G.H5.21 |
Hydrophobic | ICL3 | T | 376 | - | G.H5 | K | 376 | G.H5.21 |
Van-der-waals | ICL3 | T | 376 | - | G.H5 | K | 376 | G.H5.21 |
Polar | ICL2 | L | 285 | - | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | ICL2 | L | 285 | - | G.H5 | L | 371 | G.H5.16 |
Van-der-waals | ICL2 | L | 285 | - | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | ICL2 | A | 288 | - | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | ICL2 | A | 288 | - | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | ICL3 | T | 376 | - | G.h4s6 | P | 345 | G.h4s6.20 |
Van-der-waals | ICL3 | T | 376 | - | G.h4s6 | P | 345 | G.h4s6.20 |
Hydrophobic | ICL2 | L | 285 | - | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | ICL2 | L | 285 | - | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | ICL3 | I | 377 | - | G.H5 | Q | 372 | G.H5.17 |
Polar | TM6 | K | 386 | 6x41 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM6 | K | 386 | 6x41 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL2 | K | 286 | - | G.H5 | K | 367 | G.H5.12 |
Van-der-waals | ICL2 | K | 286 | - | G.H5 | K | 367 | G.H5.12 |
Hydrophobic | TM7 | H | 435 | 7x57 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM7 | H | 435 | 7x57 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM5 | L | 363 | 5x61 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | ICL3 | S | 375 | - | G.h4s6 | P | 345 | G.h4s6.20 |
Hydrophobic | TM6 | M | 383 | 6x38 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM6 | M | 383 | 6x38 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | TM5 | L | 370 | 5x68 | G.H5 | L | 375 | G.H5.20 |
Polar | ICL3 | N | 371 | - | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | ICL3 | N | 371 | - | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | ICL3 | V | 374 | - | G.S6 | F | 347 | G.S6.02 |
Van-der-waals | ICL3 | V | 374 | - | G.S6 | F | 347 | G.S6.02 |
Polar | TM6 | D | 379 | 6x34 | G.H5 | Q | 381 | G.H5.26 |
Polar | TM6 | K | 386 | 6x41 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | TM6 | K | 386 | 6x41 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM6 | K | 386 | 6x41 | G.H5 | M | 379 | G.H5.24 |
Polar | ICL2 | N | 289 | - | G.hns1 | V | 54 | G.hns1.01 |
Hydrophobic | ICL2 | K | 286 | - | G.H5 | I | 370 | G.H5.15 |
Polar | ICL2 | T | 291 | - | G.H5 | D | 377 | G.H5.22 |
Hydrophobic | ICL2 | T | 291 | - | G.H5 | D | 377 | G.H5.22 |
Van-der-waals | ICL2 | T | 291 | - | G.H5 | D | 377 | G.H5.22 |
Hydrophobic | TM5 | K | 366 | 5x64 | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | ICL2 | V | 287 | - | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | V | 287 | - | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | TM5 | L | 370 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | TM5 | L | 370 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | H8 | N | 439 | 8x47 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | H8 | N | 439 | 8x47 | G.H5 | L | 380 | G.H5.25 |
Polar | ICL2 | N | 289 | - | G.S1 | L | 57 | G.S1.01 |
Hydrophobic | ICL2 | K | 286 | - | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | TM3 | L | 278 | 3x54 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | L | 278 | 3x54 | G.H5 | I | 378 | G.H5.23 |
Polar | ICL2 | V | 287 | - | G.H5 | N | 374 | G.H5.19 |
Van-der-waals | ICL2 | V | 287 | - | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | ICL2 | V | 287 | - | G.hns1 | R | 56 | G.hns1.03 |
Van-der-waals | ICL2 | V | 287 | - | G.hns1 | R | 56 | G.hns1.03 |