GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 74.3
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.4
PAE mean: 24.7
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | V | 6294 | - | G.S2 | P | 193 | G.S2.05 |
Van-der-waals | C-term | V | 6294 | - | G.S2 | P | 193 | G.S2.05 |
Polar | TM6 | N | 6101 | 6x35 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM6 | N | 6101 | 6x35 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | N | 6101 | 6x35 | G.H5 | L | 358 | G.H5.25 |
Polar | C-term | S | 6196 | - | G.H2 | R | 210 | G.H2.01 |
Hydrophobic | C-term | K | 6197 | - | G.H2 | R | 210 | G.H2.01 |
Polar | C-term | T | 6199 | - | G.H3 | A | 253 | G.H3.07 |
Hydrophobic | TM2 | M | 5935 | 2x44 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM3 | V | 5998 | 3x57 | G.H5 | L | 358 | G.H5.25 |
Polar | TM6 | N | 6101 | 6x35 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM6 | N | 6101 | 6x35 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM6 | N | 6101 | 6x35 | G.H5 | Y | 356 | G.H5.23 |
Polar | TM3 | L | 5999 | 3x58 | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | TM3 | L | 5999 | 3x58 | G.hns1 | R | 37 | G.hns1.02 |
Ionic | C-term | E | 6208 | - | G.H2 | R | 214 | G.H2.05 |
Polar | C-term | E | 6208 | - | G.H2 | R | 214 | G.H2.05 |
Van-der-waals | C-term | E | 6208 | - | G.H2 | R | 214 | G.H2.05 |
Polar | TM5 | Y | 6092 | 5x66 | G.H5 | Y | 356 | G.H5.23 |
Aromatic | TM5 | Y | 6092 | 5x66 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM5 | Y | 6092 | 5x66 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM5 | Y | 6092 | 5x66 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | C-term | M | 6188 | - | G.h4s6 | P | 318 | G.h4s6.09 |
Hydrophobic | ICL2 | E | 6004 | - | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | ICL2 | E | 6004 | - | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | ICL3 | F | 6096 | - | G.H5 | K | 354 | G.H5.21 |
Van-der-waals | ICL3 | F | 6096 | - | G.H5 | K | 354 | G.H5.21 |
Hydrophobic | C-term | L | 6202 | - | G.H3 | I | 258 | G.H3.12 |
Polar | ICL3 | R | 6099 | - | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | ICL3 | R | 6099 | - | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | ICL3 | R | 6099 | - | G.H5 | N | 357 | G.H5.24 |
Polar | C-term | T | 6199 | - | G.H3 | T | 257 | G.H3.11 |
Hydrophobic | C-term | T | 6199 | - | G.H3 | T | 257 | G.H3.11 |
Van-der-waals | C-term | T | 6199 | - | G.H3 | T | 257 | G.H3.11 |
Hydrophobic | TM5 | Y | 6092 | 5x66 | G.S1 | L | 40 | G.S1.02 |
Hydrophobic | C-term | L | 6202 | - | G.H2 | R | 213 | G.H2.04 |
Van-der-waals | C-term | L | 6202 | - | G.H2 | R | 213 | G.H2.04 |
Polar | ICL2 | R | 6008 | - | G.h3s5 | Q | 265 | G.h3s5.01 |
Hydrophobic | TM6 | I | 6105 | 6x39 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | I | 6105 | 6x39 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | ICL2 | E | 6004 | - | G.H5 | N | 352 | G.H5.19 |
Van-der-waals | ICL2 | E | 6004 | - | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | TM2 | M | 5935 | 2x44 | G.H5 | V | 359 | G.H5.26 |
Polar | C-term | T | 6183 | - | G.H4 | D | 315 | G.H4.17 |
Hydrophobic | TM2 | A | 5938 | 2x47 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | C-term | A | 6205 | - | G.H2 | R | 214 | G.H2.05 |
Van-der-waals | C-term | A | 6205 | - | G.H2 | R | 214 | G.H2.05 |
Hydrophobic | C-term | M | 6206 | - | G.H2 | I | 217 | G.H2.08 |
Van-der-waals | C-term | M | 6206 | - | G.H2 | I | 217 | G.H2.08 |
Hydrophobic | C-term | L | 6202 | - | G.H2 | W | 216 | G.H2.07 |
Hydrophobic | C-term | I | 6299 | - | G.S2 | E | 191 | G.S2.03 |
Van-der-waals | C-term | I | 6299 | - | G.S2 | E | 191 | G.S2.03 |
Hydrophobic | C-term | A | 6205 | - | G.H2 | I | 217 | G.H2.08 |
Van-der-waals | C-term | A | 6205 | - | G.H2 | I | 217 | G.H2.08 |
Hydrophobic | ICL3 | F | 6096 | - | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | ICL3 | F | 6096 | - | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | ICL3 | V | 6095 | - | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | ICL3 | V | 6095 | - | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | C-term | M | 6206 | - | G.H3 | Y | 261 | G.H3.15 |
Van-der-waals | C-term | M | 6206 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | TM2 | M | 5935 | 2x44 | G.H5 | K | 354 | G.H5.21 |
Van-der-waals | TM2 | M | 5935 | 2x44 | G.H5 | K | 354 | G.H5.21 |
Polar | TM5 | Y | 6092 | 5x66 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | TM5 | Y | 6092 | 5x66 | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | TM5 | Y | 6092 | 5x66 | G.hns1 | R | 37 | G.hns1.02 |
Polar | C-term | L | 6202 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | C-term | L | 6202 | - | G.H3 | Y | 261 | G.H3.15 |
Van-der-waals | C-term | L | 6202 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | TM6 | I | 6108 | 6x42 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM6 | I | 6108 | 6x42 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | TM2 | M | 5935 | 2x44 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | C-term | I | 6301 | - | G.S2 | I | 189 | G.S2.01 |
Polar | C-term | S | 6186 | - | G.H4 | D | 315 | G.H4.17 |
Hydrophobic | C-term | S | 6186 | - | G.H4 | D | 315 | G.H4.17 |
Van-der-waals | C-term | S | 6186 | - | G.H4 | D | 315 | G.H4.17 |
Polar | TM2 | A | 5938 | 2x47 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM2 | A | 5938 | 2x47 | G.H5 | L | 358 | G.H5.25 |
Polar | C-term | I | 6203 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | C-term | I | 6203 | - | G.H3 | Y | 261 | G.H3.15 |
Van-der-waals | C-term | I | 6203 | - | G.H3 | Y | 261 | G.H3.15 |
Polar | ICL2 | H | 6005 | - | G.h3s5 | N | 266 | G.h3s5.02 |
Hydrophobic | ICL2 | H | 6005 | - | G.h3s5 | N | 266 | G.h3s5.02 |
Van-der-waals | ICL2 | H | 6005 | - | G.h3s5 | N | 266 | G.h3s5.02 |
Hydrophobic | ICL3 | V | 6095 | - | G.S3 | V | 199 | G.S3.01 |
Polar | TM2 | A | 5937 | 2x46 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM2 | A | 5937 | 2x46 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM2 | A | 5937 | 2x46 | G.H5 | L | 358 | G.H5.25 |
Polar | TM5 | Q | 6088 | 5x62 | G.HN | R | 34 | G.HN.52 |
Hydrophobic | TM5 | Q | 6088 | 5x62 | G.HN | R | 34 | G.HN.52 |
Van-der-waals | TM5 | Q | 6088 | 5x62 | G.HN | R | 34 | G.HN.52 |
Polar | ICL2 | N | 6002 | - | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL2 | N | 6002 | - | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | ICL2 | N | 6002 | - | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | C-term | F | 6181 | - | G.H4 | K | 311 | G.H4.13 |
Hydrophobic | TM5 | Y | 6092 | 5x66 | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | TM5 | Y | 6092 | 5x66 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | C-term | M | 6206 | - | G.H3 | W | 263 | G.H3.17 |
Van-der-waals | C-term | M | 6206 | - | G.H3 | W | 263 | G.H3.17 |
Hydrophobic | TM5 | P | 6087 | 5x61 | G.HN | R | 34 | G.HN.52 |
Van-der-waals | TM5 | P | 6087 | 5x61 | G.HN | R | 34 | G.HN.52 |
Hydrophobic | C-term | I | 6301 | - | G.H2 | H | 218 | G.H2.09 |
Polar | ICL2 | N | 6002 | - | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | ICL2 | N | 6002 | - | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | ICL2 | N | 6002 | - | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | H8 | Y | 6167 | 8x58 | G.H5 | D | 346 | G.H5.13 |
Van-der-waals | H8 | Y | 6167 | 8x58 | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | TM5 | V | 6085 | 5x59 | G.HN | R | 34 | G.HN.52 |
Van-der-waals | TM5 | V | 6085 | 5x59 | G.HN | R | 34 | G.HN.52 |
Polar | C-term | N | 6201 | - | G.H2 | R | 210 | G.H2.01 |
Van-der-waals | C-term | N | 6201 | - | G.H2 | R | 210 | G.H2.01 |
Hydrophobic | C-term | I | 6301 | - | G.hfs2 | G | 188 | G.hfs2.07 |
Polar | ICL2 | R | 6008 | - | G.h3s5 | N | 266 | G.h3s5.02 |
Hydrophobic | ICL2 | R | 6008 | - | G.h3s5 | N | 266 | G.h3s5.02 |
Van-der-waals | ICL2 | R | 6008 | - | G.h3s5 | N | 266 | G.h3s5.02 |
Hydrophobic | H8 | K | 6164 | 8x55 | G.H5 | K | 354 | G.H5.21 |
Van-der-waals | H8 | K | 6164 | 8x55 | G.H5 | K | 354 | G.H5.21 |
Hydrophobic | TM5 | D | 6094 | 5x68 | G.s2s3 | S | 198 | G.s2s3.02 |
Hydrophobic | ICL3 | V | 6095 | - | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | ICL3 | V | 6095 | - | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | H8 | H | 6156 | 8x47 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | H8 | H | 6156 | 8x47 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | TM6 | E | 6104 | 6x38 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM6 | E | 6104 | 6x38 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | H8 | V | 6169 | 8x60 | G.H5 | F | 339 | G.H5.06 |
Van-der-waals | H8 | V | 6169 | 8x60 | G.H5 | F | 339 | G.H5.06 |
Hydrophobic | C-term | L | 6202 | - | G.h2s4 | F | 220 | G.h2s4.01 |
Polar | ICL2 | E | 6004 | - | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL2 | E | 6004 | - | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | ICL2 | E | 6004 | - | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | C-term | I | 6301 | - | G.H2 | K | 215 | G.H2.06 |
Polar | TM3 | V | 6000 | 3x59 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | TM3 | V | 6000 | 3x59 | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | TM3 | V | 6000 | 3x59 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | TM7 | Y | 6152 | 7x57 | G.H5 | V | 359 | G.H5.26 |
Polar | TM3 | M | 6001 | 3x60 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | TM3 | M | 6001 | 3x60 | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | TM3 | M | 6001 | 3x60 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | H8 | Y | 6167 | 8x58 | G.H5 | Q | 350 | G.H5.17 |
Van-der-waals | H8 | Y | 6167 | 8x58 | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | ICL3 | V | 6095 | - | G.s2s3 | S | 198 | G.s2s3.02 |
Van-der-waals | ICL3 | V | 6095 | - | G.s2s3 | S | 198 | G.s2s3.02 |
Hydrophobic | C-term | S | 6198 | - | G.H2 | R | 210 | G.H2.01 |
Hydrophobic | ICL3 | F | 6096 | - | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | ICL3 | F | 6096 | - | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM2 | M | 5935 | 2x44 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM2 | M | 5935 | 2x44 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | C-term | S | 6196 | - | G.H3 | A | 253 | G.H3.07 |
Polar | TM5 | Q | 6088 | 5x62 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | TM5 | Q | 6088 | 5x62 | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | TM5 | Q | 6088 | 5x62 | G.hns1 | R | 37 | G.hns1.02 |
Polar | TM5 | Q | 6084 | 5x58 | G.HN | R | 34 | G.HN.52 |
Hydrophobic | TM5 | Q | 6084 | 5x58 | G.HN | R | 34 | G.HN.52 |
Van-der-waals | TM5 | Q | 6084 | 5x58 | G.HN | R | 34 | G.HN.52 |
Polar | C-term | S | 6198 | - | G.H2 | R | 213 | G.H2.04 |
Hydrophobic | C-term | S | 6198 | - | G.H2 | R | 213 | G.H2.04 |
Van-der-waals | C-term | S | 6198 | - | G.H2 | R | 213 | G.H2.04 |
Polar | TM6 | N | 6101 | 6x35 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM6 | N | 6101 | 6x35 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM6 | N | 6101 | 6x35 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM3 | V | 5998 | 3x57 | G.H5 | E | 355 | G.H5.22 |
Ionic | ICL2 | H | 6005 | - | G.H5 | E | 355 | G.H5.22 |
Polar | ICL2 | H | 6005 | - | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | ICL2 | H | 6005 | - | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | ICL2 | H | 6005 | - | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | C-term | V | 6209 | - | G.H2 | I | 217 | G.H2.08 |
Polar | C-term | T | 6183 | - | G.H4 | K | 311 | G.H4.13 |
Hydrophobic | C-term | T | 6183 | - | G.H4 | K | 311 | G.H4.13 |
Van-der-waals | C-term | T | 6183 | - | G.H4 | K | 311 | G.H4.13 |
Hydrophobic | ICL3 | F | 6096 | - | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | C-term | F | 6258 | - | G.s2s3 | Q | 197 | G.s2s3.01 |
Van-der-waals | C-term | F | 6258 | - | G.s2s3 | Q | 197 | G.s2s3.01 |
Hydrophobic | C-term | L | 6296 | - | G.S2 | Y | 192 | G.S2.04 |
Van-der-waals | C-term | L | 6296 | - | G.S2 | Y | 192 | G.S2.04 |
Hydrophobic | TM5 | A | 6091 | 5x65 | G.hns1 | R | 38 | G.hns1.03 |
Van-der-waals | TM5 | A | 6091 | 5x65 | G.hns1 | R | 38 | G.hns1.03 |
Polar | C-term | S | 6198 | - | G.H3 | E | 250 | G.H3.04 |
Hydrophobic | C-term | S | 6198 | - | G.H3 | E | 250 | G.H3.04 |
Van-der-waals | C-term | S | 6198 | - | G.H3 | E | 250 | G.H3.04 |
Hydrophobic | TM3 | L | 5999 | 3x58 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | C-term | L | 6296 | - | G.S2 | I | 190 | G.S2.02 |
Hydrophobic | TM3 | F | 5995 | 3x54 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM3 | F | 5995 | 3x54 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | C-term | F | 6181 | - | G.H4 | E | 307 | G.H4.09 |
Hydrophobic | TM3 | V | 5998 | 3x57 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | V | 5998 | 3x57 | G.H5 | Y | 356 | G.H5.23 |