GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 61.3
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.5
PAE mean: 18.5
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | K | 2637 | - | G.HN | R | 3 | G.HN.03 |
Van-der-waals | C-term | K | 2637 | - | G.HN | R | 3 | G.HN.03 |
Hydrophobic | ICL2 | V | 2471 | - | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | ICL2 | V | 2471 | - | G.H5 | R | 360 | G.H5.12 |
Aromatic | ICL3 | F | 2553 | - | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | ICL3 | F | 2553 | - | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | ICL3 | F | 2553 | - | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | C-term | L | 2655 | - | H.hbhc | Y | 122 | H.hbhc.01 |
Van-der-waals | C-term | L | 2655 | - | H.hbhc | Y | 122 | H.hbhc.01 |
Hydrophobic | C-term | M | 2900 | - | G.S2 | V | 199 | G.S2.08 |
Van-der-waals | C-term | M | 2900 | - | G.S2 | V | 199 | G.S2.08 |
Hydrophobic | C-term | I | 2898 | - | G.S2 | V | 199 | G.S2.08 |
Hydrophobic | C-term | Y | 2644 | - | G.HN | Q | 35 | G.HN.50 |
Van-der-waals | C-term | Y | 2644 | - | G.HN | Q | 35 | G.HN.50 |
Hydrophobic | C-term | L | 2634 | - | G.HN | R | 3 | G.HN.03 |
Polar | C-term | K | 2637 | - | G.HN | N | 29 | G.HN.44 |
Van-der-waals | C-term | K | 2637 | - | G.HN | N | 29 | G.HN.44 |
Hydrophobic | C-term | A | 2904 | - | G.S2 | Y | 195 | G.S2.04 |
Van-der-waals | C-term | A | 2904 | - | G.S2 | Y | 195 | G.S2.04 |
Ionic | C-term | R | 2885 | - | G.HG | E | 284 | G.HG.06 |
Polar | C-term | R | 2885 | - | G.HG | E | 284 | G.HG.06 |
Van-der-waals | C-term | R | 2885 | - | G.HG | E | 284 | G.HG.06 |
Hydrophobic | TM5 | A | 2548 | 5x64 | G.H5 | L | 368 | G.H5.20 |
Polar | C-term | I | 2898 | - | G.h1ha | G | 67 | G.h1ha.01 |
Hydrophobic | C-term | P | 2658 | - | H.hbhc | Y | 122 | H.hbhc.01 |
Polar | TM5 | G | 2552 | 5x68 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | TM5 | G | 2552 | 5x68 | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | TM5 | G | 2552 | 5x68 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | C-term | M | 2900 | - | G.H1 | M | 62 | G.H1.08 |
Van-der-waals | C-term | M | 2900 | - | G.H1 | M | 62 | G.H1.08 |
Polar | C-term | Y | 2644 | - | G.S3 | R | 205 | G.S3.04 |
Hydrophobic | C-term | Y | 2644 | - | G.S3 | R | 205 | G.S3.04 |
Van-der-waals | C-term | Y | 2644 | - | G.S3 | R | 205 | G.S3.04 |
Hydrophobic | C-term | K | 2903 | - | G.S2 | Y | 195 | G.S2.04 |
Van-der-waals | C-term | K | 2903 | - | G.S2 | Y | 195 | G.S2.04 |
Aromatic | C-term | Y | 2650 | - | G.H1 | R | 63 | G.H1.09 |
Van-der-waals | C-term | Y | 2650 | - | G.H1 | R | 63 | G.H1.09 |
Hydrophobic | C-term | L | 2655 | - | H.HA | Q | 84 | H.HA.13 |
Van-der-waals | C-term | L | 2655 | - | H.HA | Q | 84 | H.HA.13 |
Polar | C-term | M | 2900 | - | G.H1 | H | 66 | G.H1.12 |
Hydrophobic | C-term | M | 2900 | - | G.H1 | H | 66 | G.H1.12 |
Van-der-waals | C-term | M | 2900 | - | G.H1 | H | 66 | G.H1.12 |
Hydrophobic | ICL2 | V | 2471 | - | G.S3 | T | 202 | G.S3.01 |
Polar | C-term | Y | 2650 | - | G.h1ha | Y | 70 | G.h1ha.04 |
Hydrophobic | C-term | Y | 2650 | - | G.h1ha | Y | 70 | G.h1ha.04 |
Van-der-waals | C-term | Y | 2650 | - | G.h1ha | Y | 70 | G.h1ha.04 |
Polar | C-term | M | 2900 | - | G.S2 | S | 198 | G.S2.07 |
Hydrophobic | C-term | M | 2900 | - | G.S2 | S | 198 | G.S2.07 |
Van-der-waals | C-term | M | 2900 | - | G.S2 | S | 198 | G.S2.07 |
Polar | C-term | R | 2885 | - | G.HG | D | 280 | G.HG.02 |
Hydrophobic | C-term | L | 2892 | - | G.H1 | I | 64 | G.H1.10 |
Hydrophobic | C-term | M | 2900 | - | G.h1ha | G | 67 | G.h1ha.01 |
Van-der-waals | C-term | M | 2900 | - | G.h1ha | G | 67 | G.h1ha.01 |
Polar | C-term | G | 2905 | - | G.S2 | E | 194 | G.S2.03 |
Van-der-waals | C-term | G | 2905 | - | G.S2 | E | 194 | G.S2.03 |
Hydrophobic | TM3 | L | 2468 | 3x58 | G.H5 | L | 368 | G.H5.20 |
Van-der-waals | TM3 | L | 2468 | 3x58 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | TM3 | L | 2468 | 3x58 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | C-term | T | 2906 | - | G.S2 | N | 193 | G.S2.02 |
Van-der-waals | C-term | T | 2906 | - | G.S2 | N | 193 | G.S2.02 |
Hydrophobic | C-term | K | 2637 | - | G.HN | L | 32 | G.HN.47 |
Van-der-waals | C-term | K | 2637 | - | G.HN | L | 32 | G.HN.47 |
Hydrophobic | TM5 | A | 2548 | 5x64 | G.H5 | L | 364 | G.H5.16 |
Polar | H8 | K | 2614 | 8x48 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | H8 | K | 2614 | 8x48 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | C-term | L | 2655 | - | H.hbhc | V | 124 | H.hbhc.03 |
Hydrophobic | C-term | Y | 2650 | - | H.HA | F | 78 | H.HA.07 |
Van-der-waals | C-term | Y | 2650 | - | H.HA | F | 78 | H.HA.07 |
Hydrophobic | C-term | M | 2900 | - | G.H5 | I | 352 | G.H5.04 |
Hydrophobic | ICL3 | F | 2553 | - | G.H5 | D | 361 | G.H5.13 |
Van-der-waals | ICL3 | F | 2553 | - | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | C-term | Y | 2656 | - | H.hbhc | Y | 122 | H.hbhc.01 |
Van-der-waals | C-term | Y | 2656 | - | H.hbhc | Y | 122 | H.hbhc.01 |
Polar | C-term | A | 2904 | - | G.S2 | E | 194 | G.S2.03 |
Hydrophobic | C-term | A | 2904 | - | G.S2 | E | 194 | G.S2.03 |
Van-der-waals | C-term | A | 2904 | - | G.S2 | E | 194 | G.S2.03 |
Polar | ICL2 | R | 2472 | - | G.s2s3 | K | 201 | G.s2s3.02 |
Hydrophobic | ICL2 | R | 2472 | - | G.s2s3 | K | 201 | G.s2s3.02 |
Van-der-waals | ICL2 | R | 2472 | - | G.s2s3 | K | 201 | G.s2s3.02 |
Polar | ICL2 | T | 2476 | - | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | ICL2 | T | 2476 | - | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | ICL2 | T | 2476 | - | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | TM6 | V | 2559 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | C-term | I | 2902 | - | G.h1ha | G | 67 | G.h1ha.01 |
Hydrophobic | C-term | Q | 2657 | - | H.hbhc | Y | 122 | H.hbhc.01 |
Hydrophobic | C-term | L | 2892 | - | G.H1 | I | 65 | G.H1.11 |
Hydrophobic | C-term | V | 2895 | - | G.H1 | I | 65 | G.H1.11 |
Hydrophobic | ICL3 | F | 2553 | - | G.H5 | L | 368 | G.H5.20 |
Van-der-waals | ICL3 | F | 2553 | - | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | ICL2 | V | 2471 | - | G.H5 | V | 363 | G.H5.15 |
Polar | ICL3 | K | 2556 | - | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | ICL3 | K | 2556 | - | G.H5 | L | 373 | G.H5.25 |
Polar | C-term | Q | 2657 | - | H.hbhc | K | 123 | H.hbhc.02 |
Hydrophobic | C-term | Q | 2657 | - | H.hbhc | K | 123 | H.hbhc.02 |
Van-der-waals | C-term | Q | 2657 | - | H.hbhc | K | 123 | H.hbhc.02 |
Hydrophobic | ICL2 | R | 2472 | - | G.S1 | L | 43 | G.S1.02 |
Hydrophobic | ICL2 | R | 2472 | - | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | C-term | I | 2902 | - | G.H1 | R | 63 | G.H1.09 |
Van-der-waals | C-term | I | 2902 | - | G.H1 | R | 63 | G.H1.09 |
Hydrophobic | TM6 | G | 2561 | 6x38 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM6 | G | 2561 | 6x38 | G.H5 | I | 371 | G.H5.23 |
Polar | ICL2 | N | 2475 | - | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | N | 2475 | - | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | N | 2475 | - | G.H5 | Y | 367 | G.H5.19 |
Polar | C-term | M | 2900 | - | G.h1ha | A | 68 | G.h1ha.02 |
Ionic | C-term | R | 2885 | - | G.HG | E | 283 | G.HG.05 |
Polar | C-term | R | 2885 | - | G.HG | E | 283 | G.HG.05 |
Van-der-waals | C-term | R | 2885 | - | G.HG | E | 283 | G.HG.05 |
Hydrophobic | C-term | I | 2898 | - | G.H1 | H | 66 | G.H1.12 |
Van-der-waals | C-term | I | 2898 | - | G.H1 | H | 66 | G.H1.12 |
Hydrophobic | ICL2 | V | 2471 | - | G.S1 | L | 43 | G.S1.02 |
Van-der-waals | ICL2 | V | 2471 | - | G.S1 | L | 43 | G.S1.02 |
Hydrophobic | C-term | T | 2641 | - | G.HN | I | 28 | G.HN.43 |
Hydrophobic | C-term | L | 2888 | - | H.HF | L | 183 | H.HF.05 |
Hydrophobic | TM3 | L | 2464 | 3x54 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | C-term | I | 2902 | - | G.S2 | Y | 195 | G.S2.04 |
Hydrophobic | ICL3 | F | 2553 | - | G.H5 | L | 364 | G.H5.16 |
Polar | TM7 | L | 2612 | 7x60 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM7 | L | 2612 | 7x60 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | C-term | K | 2903 | - | G.S2 | E | 194 | G.S2.03 |
Hydrophobic | TM3 | A | 2467 | 3x57 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM3 | A | 2467 | 3x57 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | C-term | P | 2658 | - | H.HB | D | 120 | H.HB.13 |
Polar | C-term | K | 2903 | - | G.S2 | C | 196 | G.S2.05 |
Hydrophobic | C-term | K | 2903 | - | G.S2 | C | 196 | G.S2.05 |
Van-der-waals | C-term | K | 2903 | - | G.S2 | C | 196 | G.S2.05 |
Polar | ICL2 | R | 2472 | - | G.S3 | N | 203 | G.S3.02 |
Hydrophobic | ICL3 | K | 2556 | - | G.h4s6 | R | 335 | G.h4s6.17 |
Van-der-waals | ICL3 | K | 2556 | - | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | C-term | L | 2655 | - | H.hbhc | T | 125 | H.hbhc.04 |
Polar | ICL2 | R | 2472 | - | G.hns1 | G | 41 | G.hns1.03 |
Van-der-waals | C-term | S | 2901 | - | G.S2 | C | 196 | G.S2.05 |
Hydrophobic | ICL3 | K | 2556 | - | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | ICL3 | K | 2556 | - | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | TM6 | S | 2560 | 6x37 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | C-term | V | 2895 | - | G.H1 | H | 66 | G.H1.12 |
Van-der-waals | C-term | V | 2895 | - | G.H1 | H | 66 | G.H1.12 |
Polar | ICL2 | V | 2474 | - | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | V | 2474 | - | G.H5 | Y | 367 | G.H5.19 |
Polar | ICL2 | N | 2475 | - | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | ICL2 | N | 2475 | - | G.H5 | E | 370 | G.H5.22 |
Polar | H8 | K | 2614 | 8x48 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | H8 | K | 2614 | 8x48 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | H8 | K | 2614 | 8x48 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | C-term | L | 2888 | - | G.s6h5 | T | 347 | G.s6h5.04 |
Van-der-waals | C-term | L | 2888 | - | G.s6h5 | T | 347 | G.s6h5.04 |
Polar | C-term | I | 2902 | - | G.S2 | C | 196 | G.S2.05 |
Hydrophobic | C-term | I | 2902 | - | G.S2 | C | 196 | G.S2.05 |
Van-der-waals | C-term | I | 2902 | - | G.S2 | C | 196 | G.S2.05 |
Hydrophobic | C-term | I | 2898 | - | G.S2 | S | 198 | G.S2.07 |
Van-der-waals | C-term | I | 2898 | - | G.S2 | S | 198 | G.S2.07 |
Hydrophobic | ICL3 | E | 2554 | - | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | ICL3 | E | 2554 | - | G.H5 | L | 374 | G.H5.26 |
Aromatic | C-term | F | 2918 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | C-term | F | 2918 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | TM3 | L | 2468 | 3x58 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | ICL3 | F | 2553 | - | G.H5 | A | 365 | G.H5.17 |
Hydrophobic | C-term | G | 2905 | - | G.S2 | N | 193 | G.S2.02 |
Van-der-waals | C-term | G | 2905 | - | G.S2 | N | 193 | G.S2.02 |
Hydrophobic | TM6 | P | 2558 | 6x35 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | P | 2558 | 6x35 | G.H5 | L | 373 | G.H5.25 |
Ionic | H8 | K | 2618 | 8x52 | G.H5 | D | 369 | G.H5.21 |
Polar | H8 | K | 2618 | 8x52 | G.H5 | D | 369 | G.H5.21 |
Polar | ICL2 | D | 2473 | - | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | D | 2473 | - | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | D | 2473 | - | G.H5 | Y | 367 | G.H5.19 |
Polar | C-term | A | 2899 | - | G.S2 | S | 198 | G.S2.07 |
Hydrophobic | C-term | A | 2899 | - | G.S2 | S | 198 | G.S2.07 |
Van-der-waals | C-term | A | 2899 | - | G.S2 | S | 198 | G.S2.07 |
Polar | C-term | Q | 2891 | - | G.H5 | T | 349 | G.H5.01 |
Hydrophobic | C-term | Q | 2891 | - | G.H5 | T | 349 | G.H5.01 |
Van-der-waals | C-term | Q | 2891 | - | G.H5 | T | 349 | G.H5.01 |
Hydrophobic | C-term | Y | 2644 | - | G.S2 | E | 194 | G.S2.03 |
Van-der-waals | C-term | Y | 2644 | - | G.S2 | E | 194 | G.S2.03 |
Hydrophobic | ICL2 | V | 2471 | - | G.H5 | F | 356 | G.H5.08 |
Van-der-waals | ICL2 | V | 2471 | - | G.H5 | F | 356 | G.H5.08 |
Hydrophobic | TM6 | G | 2561 | 6x38 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | G | 2561 | 6x38 | G.H5 | L | 373 | G.H5.25 |
Polar | ICL1 | R | 2405 | 12x51 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | C-term | I | 2902 | - | G.S2 | F | 197 | G.S2.06 |
Van-der-waals | C-term | I | 2902 | - | G.S2 | F | 197 | G.S2.06 |
Hydrophobic | C-term | L | 2888 | - | H.HF | Q | 180 | H.HF.02 |
Hydrophobic | C-term | M | 2900 | - | G.S2 | F | 197 | G.S2.06 |
Van-der-waals | C-term | M | 2900 | - | G.S2 | F | 197 | G.S2.06 |
Polar | C-term | V | 2907 | - | G.S2 | I | 192 | G.S2.01 |
Van-der-waals | C-term | V | 2907 | - | G.S2 | I | 192 | G.S2.01 |
Ionic | H8 | K | 2614 | 8x48 | G.H5 | D | 369 | G.H5.21 |
Polar | H8 | K | 2614 | 8x48 | G.H5 | D | 369 | G.H5.21 |
Van-der-waals | H8 | K | 2614 | 8x48 | G.H5 | D | 369 | G.H5.21 |
Hydrophobic | C-term | L | 2655 | - | H.hbhc | K | 123 | H.hbhc.02 |