GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 83.3
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 15.6
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL3 | M | 233 | - | G.H5 | L | 371 | G.H5.16 |
Van-der-waals | ICL3 | M | 233 | - | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | ICL2 | Q | 134 | 34x54 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | Q | 134 | 34x54 | G.H5 | I | 370 | G.H5.15 |
Polar | ICL2 | Q | 134 | 34x54 | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | ICL2 | Q | 134 | 34x54 | G.hns1 | R | 56 | G.hns1.03 |
Van-der-waals | ICL2 | Q | 134 | 34x54 | G.hns1 | R | 56 | G.hns1.03 |
Polar | ICL2 | N | 135 | 34x55 | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | ICL2 | N | 135 | 34x55 | G.hns1 | R | 56 | G.hns1.03 |
Van-der-waals | ICL2 | N | 135 | 34x55 | G.hns1 | R | 56 | G.hns1.03 |
Polar | TM5 | R | 205 | 5x43 | G.HN | M | 1 | G.HN.01 |
Hydrophobic | TM5 | R | 205 | 5x43 | G.HN | M | 1 | G.HN.01 |
Van-der-waals | TM5 | R | 205 | 5x43 | G.HN | M | 1 | G.HN.01 |
Hydrophobic | H8 | G | 306 | 8x47 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | H8 | G | 306 | 8x47 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | N-term | F | 5 | - | G.HN | V | 5 | G.HN.05 |
Van-der-waals | N-term | F | 5 | - | G.HN | V | 5 | G.HN.05 |
Hydrophobic | ECL2 | T | 177 | 45x51 | G.HN | R | 6 | G.HN.06 |
Van-der-waals | ECL2 | T | 177 | 45x51 | G.HN | R | 6 | G.HN.06 |
Polar | ECL2 | T | 168 | - | G.HN | R | 10 | G.HN.10 |
Hydrophobic | ECL2 | T | 168 | - | G.HN | R | 10 | G.HN.10 |
Van-der-waals | ECL2 | T | 168 | - | G.HN | R | 10 | G.HN.10 |
Hydrophobic | TM5 | I | 228 | 5x65 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM5 | I | 228 | 5x65 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM3 | C | 126 | 3x53 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | C | 126 | 3x53 | G.H5 | I | 378 | G.H5.23 |
Polar | TM3 | W | 95 | 3x22 | G.HN | S | 9 | G.HN.09 |
Hydrophobic | TM3 | W | 95 | 3x22 | G.HN | S | 9 | G.HN.09 |
Van-der-waals | TM3 | W | 95 | 3x22 | G.HN | S | 9 | G.HN.09 |
Polar | ECL2 | T | 165 | - | G.HN | S | 9 | G.HN.09 |
Hydrophobic | ECL2 | T | 165 | - | G.HN | S | 9 | G.HN.09 |
Van-der-waals | ECL2 | T | 165 | - | G.HN | S | 9 | G.HN.09 |
Polar | ECL2 | T | 177 | 45x51 | G.HN | L | 8 | G.HN.08 |
Hydrophobic | ECL2 | T | 177 | 45x51 | G.HN | L | 8 | G.HN.08 |
Van-der-waals | ECL2 | T | 177 | 45x51 | G.HN | L | 8 | G.HN.08 |
Polar | ECL2 | F | 178 | 45x52 | G.HN | V | 5 | G.HN.05 |
Hydrophobic | ECL2 | F | 178 | 45x52 | G.HN | V | 5 | G.HN.05 |
Van-der-waals | ECL2 | F | 178 | 45x52 | G.HN | V | 5 | G.HN.05 |
Polar | H8 | Q | 307 | 8x48 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | H8 | Q | 307 | 8x48 | G.H5 | L | 380 | G.H5.25 |
Polar | TM3 | D | 106 | 3x33 | G.HN | S | 2 | G.HN.02 |
Van-der-waals | TM3 | D | 106 | 3x33 | G.HN | S | 2 | G.HN.02 |
Hydrophobic | ICL2 | V | 131 | 34x51 | G.H5 | K | 367 | G.H5.12 |
Hydrophobic | TM3 | V | 127 | 3x54 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | TM6 | R | 238 | 6x32 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | TM6 | R | 238 | 6x32 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | TM5 | L | 198 | 5x36 | G.HN | V | 5 | G.HN.05 |
Hydrophobic | ICL3 | M | 233 | - | G.H5 | Q | 372 | G.H5.17 |
Van-der-waals | ICL3 | M | 233 | - | G.H5 | Q | 372 | G.H5.17 |
Hydrophobic | ECL2 | T | 166 | - | G.HN | L | 8 | G.HN.08 |
Hydrophobic | TM4 | L | 164 | 4x65 | G.HN | L | 8 | G.HN.08 |
Hydrophobic | N-term | P | 8 | - | G.HN | R | 6 | G.HN.06 |
Van-der-waals | N-term | P | 8 | - | G.HN | R | 6 | G.HN.06 |
Ionic | ICL2 | R | 137 | 34x57 | G.H5 | D | 377 | G.H5.22 |
Polar | ICL2 | R | 137 | 34x57 | G.H5 | D | 377 | G.H5.22 |
Van-der-waals | ICL2 | R | 137 | 34x57 | G.H5 | D | 377 | G.H5.22 |
Hydrophobic | ICL2 | Q | 134 | 34x54 | G.S1 | V | 58 | G.S1.02 |
Polar | TM5 | R | 201 | 5x39 | G.HN | V | 4 | G.HN.04 |
Hydrophobic | TM5 | R | 201 | 5x39 | G.HN | V | 4 | G.HN.04 |
Van-der-waals | TM5 | R | 201 | 5x39 | G.HN | V | 4 | G.HN.04 |
Polar | ECL2 | F | 178 | 45x52 | G.HN | T | 7 | G.HN.07 |
Hydrophobic | ECL2 | F | 178 | 45x52 | G.HN | T | 7 | G.HN.07 |
Van-der-waals | ECL2 | F | 178 | 45x52 | G.HN | T | 7 | G.HN.07 |
Hydrophobic | ICL2 | P | 130 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ECL2 | F | 178 | 45x52 | G.HN | L | 8 | G.HN.08 |
Hydrophobic | TM3 | V | 127 | 3x54 | G.H5 | L | 371 | G.H5.16 |
Van-der-waals | TM3 | V | 127 | 3x54 | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | TM7 | V | 303 | 7x54 | G.H5 | L | 380 | G.H5.25 |
Polar | ICL2 | Q | 134 | 34x54 | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | ICL2 | Q | 134 | 34x54 | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | ICL2 | Q | 134 | 34x54 | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | TM3 | V | 113 | 3x40 | G.HN | M | 1 | G.HN.01 |
Polar | ECL2 | T | 165 | - | G.HN | R | 10 | G.HN.10 |
Van-der-waals | ECL2 | T | 165 | - | G.HN | R | 10 | G.HN.10 |
Polar | ICL2 | P | 130 | 34x50 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | ICL2 | P | 130 | 34x50 | G.H5 | N | 374 | G.H5.19 |
Van-der-waals | ICL2 | P | 130 | 34x50 | G.H5 | N | 374 | G.H5.19 |
Polar | ECL2 | T | 166 | - | G.HN | R | 10 | G.HN.10 |
Van-der-waals | ECL2 | T | 166 | - | G.HN | R | 10 | G.HN.10 |
Hydrophobic | TM3 | F | 110 | 3x37 | G.HN | M | 1 | G.HN.01 |
Van-der-waals | TM3 | F | 110 | 3x37 | G.HN | M | 1 | G.HN.01 |
Hydrophobic | ECL2 | F | 178 | 45x52 | G.HN | V | 4 | G.HN.04 |
Van-der-waals | ECL2 | F | 178 | 45x52 | G.HN | V | 4 | G.HN.04 |
Van-der-waals | TM6 | Q | 258 | 6x52 | G.HN | M | 1 | G.HN.01 |
Polar | TM5 | R | 205 | 5x43 | G.HN | S | 2 | G.HN.02 |
Hydrophobic | TM4 | F | 163 | 4x64 | G.HN | L | 8 | G.HN.08 |
Van-der-waals | TM4 | F | 163 | 4x64 | G.HN | L | 8 | G.HN.08 |
Polar | TM3 | R | 123 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | TM3 | R | 123 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | R | 123 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | ICL3 | K | 235 | - | G.h4s6 | K | 344 | G.h4s6.19 |
Van-der-waals | ICL3 | K | 235 | - | G.h4s6 | K | 344 | G.h4s6.19 |
Polar | ECL2 | T | 177 | 45x51 | G.HN | T | 7 | G.HN.07 |
Hydrophobic | ECL2 | T | 177 | 45x51 | G.HN | T | 7 | G.HN.07 |
Van-der-waals | ECL2 | T | 177 | 45x51 | G.HN | T | 7 | G.HN.07 |
Hydrophobic | ICL2 | P | 130 | 34x50 | G.H5 | K | 367 | G.H5.12 |
Hydrophobic | TM2 | Y | 64 | 2x43 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM2 | Y | 64 | 2x43 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ECL2 | F | 178 | 45x52 | G.HN | R | 6 | G.HN.06 |
Van-der-waals | ECL2 | F | 178 | 45x52 | G.HN | R | 6 | G.HN.06 |
Hydrophobic | TM5 | K | 231 | 5x68 | G.H5 | L | 371 | G.H5.16 |
Van-der-waals | TM5 | K | 231 | 5x68 | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | ICL2 | N | 135 | 34x55 | G.S3 | I | 221 | G.S3.01 |
Hydrophobic | TM4 | T | 138 | 4x38 | G.HN | R | 52 | G.HN.52 |
Ionic | TM5 | K | 231 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Polar | TM5 | K | 231 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | TM5 | K | 231 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | TM5 | K | 231 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Aromatic | ICL2 | H | 136 | 34x56 | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | H8 | D | 308 | 8x49 | G.H5 | Q | 381 | G.H5.26 |
Polar | ECL2 | T | 166 | - | G.HN | S | 9 | G.HN.09 |
Hydrophobic | ECL2 | T | 166 | - | G.HN | S | 9 | G.HN.09 |
Van-der-waals | ECL2 | T | 166 | - | G.HN | S | 9 | G.HN.09 |
Polar | TM3 | V | 105 | 3x32 | G.HN | M | 1 | G.HN.01 |
Hydrophobic | ECL2 | T | 165 | - | G.HN | L | 8 | G.HN.08 |
Van-der-waals | ECL2 | T | 165 | - | G.HN | L | 8 | G.HN.08 |
Hydrophobic | TM3 | V | 127 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM3 | V | 127 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Polar | TM5 | R | 201 | 5x39 | G.HN | S | 2 | G.HN.02 |
Hydrophobic | H8 | F | 309 | 8x50 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM3 | W | 95 | 3x22 | G.HN | C | 11 | G.HN.11 |
Hydrophobic | TM2 | T | 60 | 2x39 | G.H5 | I | 378 | G.H5.23 |
Polar | N-term | S | 6 | - | G.HN | T | 7 | G.HN.07 |
Hydrophobic | N-term | S | 6 | - | G.HN | T | 7 | G.HN.07 |
Van-der-waals | N-term | S | 6 | - | G.HN | T | 7 | G.HN.07 |
Hydrophobic | TM3 | V | 105 | 3x32 | G.HN | S | 2 | G.HN.02 |
Van-der-waals | TM3 | V | 105 | 3x32 | G.HN | S | 2 | G.HN.02 |
Polar | TM3 | C | 126 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | TM3 | C | 126 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Van-der-waals | TM3 | C | 126 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | ECL2 | V | 167 | - | G.HN | L | 8 | G.HN.08 |
Van-der-waals | ECL2 | V | 167 | - | G.HN | L | 8 | G.HN.08 |
Hydrophobic | TM3 | H | 102 | 3x29 | G.HN | V | 4 | G.HN.04 |
Van-der-waals | TM3 | H | 102 | 3x29 | G.HN | V | 4 | G.HN.04 |
Hydrophobic | ICL2 | V | 131 | 34x51 | G.S3 | I | 221 | G.S3.01 |
Van-der-waals | ICL2 | V | 131 | 34x51 | G.S3 | I | 221 | G.S3.01 |
Hydrophobic | TM5 | G | 209 | 5x461 | G.HN | M | 1 | G.HN.01 |
Van-der-waals | TM5 | G | 209 | 5x461 | G.HN | M | 1 | G.HN.01 |
Polar | ICL3 | K | 235 | - | G.h4s6 | S | 343 | G.h4s6.12 |
Hydrophobic | ICL3 | K | 235 | - | G.h4s6 | S | 343 | G.h4s6.12 |
Van-der-waals | ICL3 | K | 235 | - | G.h4s6 | S | 343 | G.h4s6.12 |
Polar | ICL2 | N | 135 | 34x55 | G.s2s3 | K | 220 | G.s2s3.02 |
Van-der-waals | ICL2 | N | 135 | 34x55 | G.s2s3 | K | 220 | G.s2s3.02 |
Hydrophobic | TM6 | W | 254 | 6x48 | G.HN | M | 1 | G.HN.01 |
Hydrophobic | TM2 | T | 60 | 2x39 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL3 | M | 233 | - | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | ICL2 | V | 131 | 34x51 | G.H5 | F | 363 | G.H5.08 |
Hydrophobic | TM6 | V | 242 | 6x36 | G.H5 | M | 379 | G.H5.24 |
Polar | ECL2 | N | 179 | - | G.HN | L | 8 | G.HN.08 |
Hydrophobic | ECL2 | N | 179 | - | G.HN | L | 8 | G.HN.08 |
Van-der-waals | ECL2 | N | 179 | - | G.HN | L | 8 | G.HN.08 |
Hydrophobic | ECL2 | V | 167 | - | G.HN | S | 9 | G.HN.09 |
Hydrophobic | ECL2 | N | 179 | - | G.HN | T | 7 | G.HN.07 |
Van-der-waals | ECL2 | N | 179 | - | G.HN | T | 7 | G.HN.07 |
Hydrophobic | ICL2 | P | 130 | 34x50 | G.H5 | L | 371 | G.H5.16 |
Polar | N-term | S | 6 | - | G.HN | R | 6 | G.HN.06 |
Hydrophobic | N-term | S | 6 | - | G.HN | R | 6 | G.HN.06 |
Van-der-waals | N-term | S | 6 | - | G.HN | R | 6 | G.HN.06 |
Hydrophobic | TM7 | V | 305 | 7x56 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | TM4 | L | 164 | 4x65 | G.HN | V | 4 | G.HN.04 |
Van-der-waals | TM4 | L | 164 | 4x65 | G.HN | V | 4 | G.HN.04 |
Polar | TM2 | T | 60 | 2x39 | G.H5 | D | 377 | G.H5.22 |
Hydrophobic | TM2 | T | 60 | 2x39 | G.H5 | D | 377 | G.H5.22 |
Van-der-waals | TM2 | T | 60 | 2x39 | G.H5 | D | 377 | G.H5.22 |
Hydrophobic | TM4 | S | 140 | 4x40 | G.HN | R | 52 | G.HN.52 |
Van-der-waals | TM4 | S | 140 | 4x40 | G.HN | R | 52 | G.HN.52 |
Polar | H8 | D | 308 | 8x49 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | H8 | D | 308 | 8x49 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | H8 | D | 308 | 8x49 | G.H5 | L | 380 | G.H5.25 |
Polar | TM2 | Y | 64 | 2x43 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM2 | Y | 64 | 2x43 | G.H5 | I | 378 | G.H5.23 |
Polar | TM3 | D | 106 | 3x33 | G.HN | M | 1 | G.HN.01 |
Hydrophobic | TM3 | D | 106 | 3x33 | G.HN | M | 1 | G.HN.01 |
Van-der-waals | TM3 | D | 106 | 3x33 | G.HN | M | 1 | G.HN.01 |
Hydrophobic | TM6 | P | 239 | 6x33 | G.H5 | M | 379 | G.H5.24 |
Polar | H8 | G | 306 | 8x47 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | H8 | G | 306 | 8x47 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | H8 | G | 306 | 8x47 | G.H5 | M | 379 | G.H5.24 |
Polar | TM3 | W | 95 | 3x22 | G.HN | R | 10 | G.HN.10 |
Hydrophobic | TM3 | W | 95 | 3x22 | G.HN | R | 10 | G.HN.10 |
Van-der-waals | TM3 | W | 95 | 3x22 | G.HN | R | 10 | G.HN.10 |
Polar | ECL2 | V | 167 | - | G.HN | T | 7 | G.HN.07 |
Hydrophobic | ECL2 | V | 167 | - | G.HN | T | 7 | G.HN.07 |
Van-der-waals | ECL2 | V | 167 | - | G.HN | T | 7 | G.HN.07 |
Hydrophobic | TM1 | M | 55 | 1x61 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM7 | F | 292 | 7x42 | G.HN | S | 2 | G.HN.02 |
Hydrophobic | TM3 | L | 109 | 3x36 | G.HN | M | 1 | G.HN.01 |
Van-der-waals | TM3 | L | 109 | 3x36 | G.HN | M | 1 | G.HN.01 |
Ionic | ECL1 | E | 89 | - | G.HN | R | 6 | G.HN.06 |
Polar | ECL1 | E | 89 | - | G.HN | R | 6 | G.HN.06 |
Hydrophobic | ECL1 | E | 89 | - | G.HN | R | 6 | G.HN.06 |
Van-der-waals | ECL1 | E | 89 | - | G.HN | R | 6 | G.HN.06 |