GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 83.7
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 16.1
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ECL2 | T | 177 | 45x51 | G.HN | F | 4 | G.HN.04 |
Van-der-waals | ECL2 | T | 177 | 45x51 | G.HN | F | 4 | G.HN.04 |
Hydrophobic | ICL2 | Q | 134 | 34x54 | G.H5 | I | 366 | G.H5.15 |
Van-der-waals | ICL2 | Q | 134 | 34x54 | G.H5 | I | 366 | G.H5.15 |
Hydrophobic | ICL3 | M | 233 | - | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM6 | P | 239 | 6x33 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | P | 239 | 6x33 | G.H5 | M | 375 | G.H5.24 |
Polar | TM4 | V | 160 | 4x61 | G.HN | L | 5 | G.HN.05 |
Hydrophobic | TM4 | V | 160 | 4x61 | G.HN | L | 5 | G.HN.05 |
Van-der-waals | TM4 | V | 160 | 4x61 | G.HN | L | 5 | G.HN.05 |
Hydrophobic | TM4 | V | 160 | 4x61 | G.HN | A | 2 | G.HN.02 |
Van-der-waals | TM4 | V | 160 | 4x61 | G.HN | A | 2 | G.HN.02 |
Hydrophobic | ECL2 | F | 178 | 45x52 | G.HN | D | 3 | G.HN.03 |
Van-der-waals | ECL2 | F | 178 | 45x52 | G.HN | D | 3 | G.HN.03 |
Hydrophobic | TM3 | D | 106 | 3x33 | G.HN | A | 2 | G.HN.02 |
Van-der-waals | TM3 | D | 106 | 3x33 | G.HN | A | 2 | G.HN.02 |
Polar | TM3 | H | 102 | 3x29 | G.HN | M | 1 | G.HN.01 |
Hydrophobic | TM3 | H | 102 | 3x29 | G.HN | M | 1 | G.HN.01 |
Van-der-waals | TM3 | H | 102 | 3x29 | G.HN | M | 1 | G.HN.01 |
Hydrophobic | ICL3 | M | 233 | - | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | ICL3 | M | 233 | - | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM6 | V | 242 | 6x36 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | V | 242 | 6x36 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | ICL3 | M | 233 | - | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | ICL3 | M | 233 | - | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | TM7 | Y | 302 | 7x53 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM7 | Y | 302 | 7x53 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | ECL2 | T | 165 | - | G.HN | F | 4 | G.HN.04 |
Van-der-waals | ECL2 | T | 165 | - | G.HN | F | 4 | G.HN.04 |
Ionic | TM5 | R | 201 | 5x39 | G.HN | D | 3 | G.HN.03 |
Polar | TM5 | R | 201 | 5x39 | G.HN | D | 3 | G.HN.03 |
Hydrophobic | TM5 | R | 201 | 5x39 | G.HN | D | 3 | G.HN.03 |
Van-der-waals | TM5 | R | 201 | 5x39 | G.HN | D | 3 | G.HN.03 |
Polar | TM3 | C | 126 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM3 | C | 126 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Van-der-waals | TM3 | C | 126 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM3 | I | 103 | 3x30 | G.HN | L | 5 | G.HN.05 |
Van-der-waals | TM3 | I | 103 | 3x30 | G.HN | L | 5 | G.HN.05 |
Hydrophobic | ICL3 | I | 234 | - | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM3 | I | 103 | 3x30 | G.HN | A | 2 | G.HN.02 |
Hydrophobic | TM7 | F | 292 | 7x42 | G.HN | M | 1 | G.HN.01 |
Van-der-waals | TM7 | F | 292 | 7x42 | G.HN | M | 1 | G.HN.01 |
Polar | TM4 | V | 160 | 4x61 | G.HN | D | 3 | G.HN.03 |
Hydrophobic | TM4 | V | 160 | 4x61 | G.HN | D | 3 | G.HN.03 |
Van-der-waals | TM4 | V | 160 | 4x61 | G.HN | D | 3 | G.HN.03 |
Hydrophobic | ICL2 | V | 131 | 34x51 | G.H5 | F | 359 | G.H5.08 |
Hydrophobic | TM2 | Y | 64 | 2x43 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM2 | Y | 64 | 2x43 | G.H5 | L | 376 | G.H5.25 |
Polar | ICL2 | P | 130 | 34x50 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM4 | L | 164 | 4x65 | G.HN | D | 3 | G.HN.03 |
Van-der-waals | TM4 | L | 164 | 4x65 | G.HN | D | 3 | G.HN.03 |
Hydrophobic | ICL2 | V | 131 | 34x51 | G.H5 | I | 366 | G.H5.15 |
Hydrophobic | TM3 | V | 127 | 3x54 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM3 | V | 127 | 3x54 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM3 | W | 95 | 3x22 | G.HN | P | 6 | G.HN.06 |
Hydrophobic | TM5 | K | 231 | 5x68 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM5 | K | 231 | 5x68 | G.H5 | L | 367 | G.H5.16 |
Polar | TM4 | L | 162 | 4x63 | G.HN | L | 5 | G.HN.05 |
Van-der-waals | TM4 | L | 162 | 4x63 | G.HN | L | 5 | G.HN.05 |
Polar | TM4 | V | 160 | 4x61 | G.HN | F | 4 | G.HN.04 |
Hydrophobic | TM4 | V | 160 | 4x61 | G.HN | F | 4 | G.HN.04 |
Van-der-waals | TM4 | V | 160 | 4x61 | G.HN | F | 4 | G.HN.04 |
Hydrophobic | TM2 | L | 81 | 2x60 | G.HN | M | 1 | G.HN.01 |
Hydrophobic | TM5 | I | 228 | 5x65 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM5 | I | 228 | 5x65 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | ICL2 | P | 130 | 34x50 | G.H5 | K | 363 | G.H5.12 |
Polar | TM3 | K | 99 | 3x26 | G.HN | F | 4 | G.HN.04 |
Hydrophobic | TM3 | K | 99 | 3x26 | G.HN | F | 4 | G.HN.04 |
Van-der-waals | TM3 | K | 99 | 3x26 | G.HN | F | 4 | G.HN.04 |
Hydrophobic | ICL2 | P | 130 | 34x50 | G.H5 | L | 367 | G.H5.16 |
Polar | TM4 | F | 161 | 4x62 | G.HN | S | 7 | G.HN.09 |
Hydrophobic | TM4 | F | 161 | 4x62 | G.HN | S | 7 | G.HN.09 |
Van-der-waals | TM4 | F | 161 | 4x62 | G.HN | S | 7 | G.HN.09 |
Hydrophobic | TM3 | V | 127 | 3x54 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM3 | V | 127 | 3x54 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM4 | F | 161 | 4x62 | G.HN | R | 8 | G.HN.10 |
Hydrophobic | TM3 | V | 105 | 3x32 | G.HN | M | 1 | G.HN.01 |
Van-der-waals | TM3 | V | 105 | 3x32 | G.HN | M | 1 | G.HN.01 |
Hydrophobic | TM3 | C | 98 | 3x25 | G.HN | F | 4 | G.HN.04 |
Van-der-waals | TM3 | C | 98 | 3x25 | G.HN | F | 4 | G.HN.04 |
Hydrophobic | TM6 | R | 238 | 6x32 | G.H5 | M | 375 | G.H5.24 |
Polar | TM5 | R | 201 | 5x39 | G.HN | A | 2 | G.HN.02 |
Hydrophobic | TM5 | R | 201 | 5x39 | G.HN | A | 2 | G.HN.02 |
Van-der-waals | TM5 | R | 201 | 5x39 | G.HN | A | 2 | G.HN.02 |
Polar | TM3 | R | 123 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM3 | R | 123 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | R | 123 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Aromatic | TM3 | H | 102 | 3x29 | G.HN | F | 4 | G.HN.04 |
Hydrophobic | TM3 | H | 102 | 3x29 | G.HN | F | 4 | G.HN.04 |
Van-der-waals | TM3 | H | 102 | 3x29 | G.HN | F | 4 | G.HN.04 |
Hydrophobic | H8 | G | 306 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | H8 | G | 306 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | ICL3 | M | 233 | - | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | ICL3 | M | 233 | - | G.H5 | L | 367 | G.H5.16 |
Ionic | TM5 | R | 205 | 5x43 | G.HN | D | 3 | G.HN.03 |
Ionic | TM5 | K | 231 | 5x68 | G.H5 | D | 364 | G.H5.13 |
Polar | TM5 | K | 231 | 5x68 | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | TM5 | K | 231 | 5x68 | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | TM5 | K | 231 | 5x68 | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | ECL2 | C | 176 | 45x50 | G.HN | F | 4 | G.HN.04 |
Van-der-waals | ECL2 | C | 176 | 45x50 | G.HN | F | 4 | G.HN.04 |
Hydrophobic | ICL2 | V | 131 | 34x51 | G.H5 | K | 363 | G.H5.12 |
Polar | TM3 | K | 99 | 3x26 | G.HN | L | 5 | G.HN.05 |
Hydrophobic | TM3 | K | 99 | 3x26 | G.HN | L | 5 | G.HN.05 |
Van-der-waals | TM3 | K | 99 | 3x26 | G.HN | L | 5 | G.HN.05 |
Hydrophobic | TM3 | V | 127 | 3x54 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | V | 127 | 3x54 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM3 | K | 99 | 3x26 | G.HN | P | 6 | G.HN.06 |
Van-der-waals | TM3 | K | 99 | 3x26 | G.HN | P | 6 | G.HN.06 |
Hydrophobic | TM7 | V | 303 | 7x54 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM7 | V | 303 | 7x54 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM4 | L | 164 | 4x65 | G.HN | F | 4 | G.HN.04 |
Van-der-waals | TM4 | L | 164 | 4x65 | G.HN | F | 4 | G.HN.04 |
Polar | TM4 | F | 161 | 4x62 | G.HN | P | 6 | G.HN.06 |
Hydrophobic | TM4 | F | 161 | 4x62 | G.HN | P | 6 | G.HN.06 |
Van-der-waals | TM4 | F | 161 | 4x62 | G.HN | P | 6 | G.HN.06 |
Hydrophobic | H8 | Q | 307 | 8x48 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM3 | H | 102 | 3x29 | G.HN | A | 2 | G.HN.02 |
Van-der-waals | TM3 | H | 102 | 3x29 | G.HN | A | 2 | G.HN.02 |
Hydrophobic | ICL2 | P | 130 | 34x50 | G.H5 | I | 366 | G.H5.15 |
Polar | ICL2 | H | 136 | 34x56 | G.hns1 | R | 47 | G.hns1.03 |
Aromatic | ICL2 | H | 136 | 34x56 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | H | 136 | 34x56 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | H | 136 | 34x56 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | TM3 | L | 100 | 3x27 | G.HN | L | 5 | G.HN.05 |
Van-der-waals | TM3 | L | 100 | 3x27 | G.HN | L | 5 | G.HN.05 |
Polar | H8 | Q | 307 | 8x48 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | H8 | Q | 307 | 8x48 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM2 | T | 60 | 2x39 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM6 | R | 238 | 6x32 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM6 | R | 238 | 6x32 | G.H5 | Q | 377 | G.H5.26 |
Polar | H8 | D | 308 | 8x49 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | H8 | D | 308 | 8x49 | G.H5 | L | 376 | G.H5.25 |
Polar | ICL2 | N | 135 | 34x55 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | N | 135 | 34x55 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | N | 135 | 34x55 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | TM5 | K | 227 | 5x64 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | ICL2 | V | 131 | 34x51 | G.S3 | V | 216 | G.S3.01 |
Van-der-waals | ICL2 | V | 131 | 34x51 | G.S3 | V | 216 | G.S3.01 |
Polar | TM4 | F | 161 | 4x62 | G.HN | L | 5 | G.HN.05 |
Hydrophobic | TM4 | F | 161 | 4x62 | G.HN | L | 5 | G.HN.05 |
Van-der-waals | TM4 | F | 161 | 4x62 | G.HN | L | 5 | G.HN.05 |