GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 68.3
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 24.5
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM3 | R | 128 | 3x62 | G.HN | L | 23 | G.HN.47 |
Van-der-waals | TM3 | R | 128 | 3x62 | G.HN | L | 23 | G.HN.47 |
Polar | TM3 | R | 128 | 3x62 | G.HN | E | 25 | G.HN.49 |
Hydrophobic | TM3 | R | 128 | 3x62 | G.HN | E | 25 | G.HN.49 |
Van-der-waals | TM3 | R | 128 | 3x62 | G.HN | E | 25 | G.HN.49 |
Polar | ICL2 | R | 129 | - | G.HN | L | 23 | G.HN.47 |
Hydrophobic | ICL2 | R | 129 | - | G.HN | L | 23 | G.HN.47 |
Van-der-waals | ICL2 | R | 129 | - | G.HN | L | 23 | G.HN.47 |
Polar | ICL2 | R | 129 | - | G.HN | I | 19 | G.HN.43 |
Van-der-waals | ICL2 | R | 129 | - | G.HN | I | 19 | G.HN.43 |
Hydrophobic | TM3 | K | 127 | 3x61 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | TM3 | K | 127 | 3x61 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | C-term | L | 401 | - | H.hbhc | T | 117 | H.hbhc.05 |
Van-der-waals | C-term | L | 401 | - | H.hbhc | T | 117 | H.hbhc.05 |
Polar | TM4 | R | 140 | 4x46 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM4 | R | 140 | 4x46 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM5 | A | 201 | 5x65 | G.HN | I | 28 | G.HN.52 |
Van-der-waals | TM5 | A | 201 | 5x65 | G.HN | I | 28 | G.HN.52 |
Hydrophobic | TM2 | S | 57 | 2x41 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM2 | S | 57 | 2x41 | G.H5 | Y | 354 | G.H5.26 |
Polar | ICL1 | K | 54 | - | G.h4s6 | N | 316 | G.h4s6.10 |
Hydrophobic | ICL1 | K | 54 | - | G.h4s6 | N | 316 | G.h4s6.10 |
Van-der-waals | ICL1 | K | 54 | - | G.h4s6 | N | 316 | G.h4s6.10 |
Polar | ICL1 | H | 53 | - | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM5 | R | 200 | 5x64 | G.HN | K | 24 | G.HN.48 |
Hydrophobic | TM3 | K | 123 | 3x57 | G.H5 | G | 350 | G.H5.22 |
Van-der-waals | TM3 | K | 123 | 3x57 | G.H5 | G | 350 | G.H5.22 |
Hydrophobic | ICL3 | S | 203 | - | G.H5 | I | 343 | G.H5.15 |
Aromatic | C-term | W | 402 | - | G.hfs2 | R | 179 | G.hfs2.02 |
Hydrophobic | C-term | W | 402 | - | G.hfs2 | R | 179 | G.hfs2.02 |
Van-der-waals | C-term | W | 402 | - | G.hfs2 | R | 179 | G.hfs2.02 |
Hydrophobic | TM3 | K | 127 | 3x61 | G.HN | G | 27 | G.HN.51 |
Van-der-waals | TM3 | K | 127 | 3x61 | G.HN | G | 27 | G.HN.51 |
Polar | TM2 | Y | 58 | 2x42 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL3 | P | 202 | - | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | ICL3 | P | 202 | - | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | TM3 | K | 123 | 3x57 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | K | 123 | 3x57 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL3 | I | 206 | - | G.H5 | F | 336 | G.H5.08 |
Van-der-waals | ICL3 | I | 206 | - | G.H5 | F | 336 | G.H5.08 |
Polar | TM3 | A | 124 | 3x58 | G.HN | I | 28 | G.HN.52 |
Hydrophobic | TM3 | A | 124 | 3x58 | G.HN | I | 28 | G.HN.52 |
Van-der-waals | TM3 | A | 124 | 3x58 | G.HN | I | 28 | G.HN.52 |
Polar | TM2 | S | 57 | 2x41 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM2 | S | 57 | 2x41 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM2 | S | 57 | 2x41 | G.H5 | L | 353 | G.H5.25 |
Polar | TM3 | Q | 119 | 3x53 | G.H5 | G | 350 | G.H5.22 |
Van-der-waals | TM3 | Q | 119 | 3x53 | G.H5 | G | 350 | G.H5.22 |
Hydrophobic | ICL3 | Y | 207 | - | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL3 | Y | 207 | - | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | ICL3 | Y | 207 | - | G.H5 | T | 340 | G.H5.12 |
Van-der-waals | ICL3 | Y | 207 | - | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | ICL3 | P | 202 | - | G.HN | I | 28 | G.HN.52 |
Hydrophobic | TM2 | Y | 58 | 2x42 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM2 | Y | 58 | 2x42 | G.H5 | G | 352 | G.H5.24 |
Polar | TM3 | R | 128 | 3x62 | G.HN | K | 24 | G.HN.48 |
Hydrophobic | TM3 | R | 128 | 3x62 | G.HN | K | 24 | G.HN.48 |
Van-der-waals | TM3 | R | 128 | 3x62 | G.HN | K | 24 | G.HN.48 |
Hydrophobic | TM3 | Y | 116 | 3x50 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | Y | 116 | 3x50 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL3 | S | 203 | - | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL3 | S | 203 | - | G.S3 | L | 195 | G.S3.01 |
Polar | TM3 | R | 128 | 3x62 | G.HN | G | 27 | G.HN.51 |
Hydrophobic | TM3 | R | 128 | 3x62 | G.HN | G | 27 | G.HN.51 |
Van-der-waals | TM3 | R | 128 | 3x62 | G.HN | G | 27 | G.HN.51 |
Polar | ICL2 | R | 129 | - | G.HN | K | 21 | G.HN.45 |
Van-der-waals | ICL2 | R | 129 | - | G.HN | K | 21 | G.HN.45 |
Hydrophobic | ICL3 | P | 202 | - | G.s2s3 | N | 194 | G.s2s3.02 |
Van-der-waals | ICL3 | P | 202 | - | G.s2s3 | N | 194 | G.s2s3.02 |
Hydrophobic | ICL3 | A | 210 | - | G.H5 | F | 336 | G.H5.08 |
Hydrophobic | ICL3 | I | 206 | - | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL3 | I | 206 | - | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | TM5 | R | 200 | 5x64 | G.HN | I | 28 | G.HN.52 |
Van-der-waals | TM5 | R | 200 | 5x64 | G.HN | I | 28 | G.HN.52 |
Polar | TM3 | R | 128 | 3x62 | G.HN | S | 29 | G.HN.53 |
Van-der-waals | TM3 | R | 128 | 3x62 | G.HN | S | 29 | G.HN.53 |
Polar | ICL1 | K | 54 | - | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | ICL1 | K | 54 | - | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | ICL1 | K | 54 | - | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM3 | K | 125 | 3x59 | G.HN | I | 28 | G.HN.52 |
Hydrophobic | ICL3 | I | 206 | - | G.s2s3 | N | 194 | G.s2s3.02 |
Polar | ICL3 | S | 203 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL3 | S | 203 | - | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL3 | S | 203 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | TM3 | V | 120 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | V | 120 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM3 | Y | 116 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM3 | Y | 116 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Polar | TM3 | K | 127 | 3x61 | G.h2s4 | T | 220 | G.h2s4.05 |
Hydrophobic | TM3 | V | 120 | 3x54 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | L | 115 | 3x49 | G.H5 | L | 353 | G.H5.25 |
Polar | TM3 | K | 123 | 3x57 | G.H5 | N | 346 | G.H5.18 |
Hydrophobic | TM3 | K | 123 | 3x57 | G.H5 | N | 346 | G.H5.18 |
Van-der-waals | TM3 | K | 123 | 3x57 | G.H5 | N | 346 | G.H5.18 |
Hydrophobic | TM3 | K | 123 | 3x57 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | K | 123 | 3x57 | G.H5 | N | 347 | G.H5.19 |
Polar | TM2 | Y | 58 | 2x42 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM2 | Y | 58 | 2x42 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM2 | Y | 58 | 2x42 | G.H5 | L | 353 | G.H5.25 |
Polar | TM3 | V | 120 | 3x54 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | V | 120 | 3x54 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | V | 120 | 3x54 | G.H5 | C | 351 | G.H5.23 |
Ionic | ICL2 | R | 129 | - | G.HN | E | 20 | G.HN.44 |
Polar | ICL2 | R | 129 | - | G.HN | E | 20 | G.HN.44 |
Hydrophobic | ICL2 | R | 129 | - | G.HN | E | 20 | G.HN.44 |
Van-der-waals | ICL2 | R | 129 | - | G.HN | E | 20 | G.HN.44 |
Polar | TM3 | Q | 119 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | Q | 119 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | Q | 119 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL2 | R | 129 | - | G.HN | K | 24 | G.HN.48 |
Van-der-waals | ICL2 | R | 129 | - | G.HN | K | 24 | G.HN.48 |
Hydrophobic | ICL3 | A | 210 | - | G.H5 | T | 340 | G.H5.12 |
Polar | TM3 | R | 128 | 3x62 | G.HN | I | 28 | G.HN.52 |
Hydrophobic | TM3 | R | 128 | 3x62 | G.HN | I | 28 | G.HN.52 |
Van-der-waals | TM3 | R | 128 | 3x62 | G.HN | I | 28 | G.HN.52 |
Hydrophobic | ICL3 | I | 206 | - | G.s2s3 | K | 193 | G.s2s3.01 |
Van-der-waals | ICL3 | I | 206 | - | G.s2s3 | K | 193 | G.s2s3.01 |
Hydrophobic | TM3 | R | 128 | 3x62 | G.HN | D | 26 | G.HN.50 |
Van-der-waals | TM3 | R | 128 | 3x62 | G.HN | D | 26 | G.HN.50 |
Hydrophobic | ICL3 | I | 206 | - | G.H5 | T | 340 | G.H5.12 |
Van-der-waals | ICL3 | I | 206 | - | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | TM3 | V | 120 | 3x54 | G.H5 | L | 353 | G.H5.25 |