GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 70.6
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 25.9
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | ICL1 | K | 54 | - | G.s2s3 | K | 216 | G.s2s3.02 |
Hydrophobic | ICL1 | K | 54 | - | G.s2s3 | K | 216 | G.s2s3.02 |
Van-der-waals | ICL1 | K | 54 | - | G.s2s3 | K | 216 | G.s2s3.02 |
Polar | TM1 | Q | 44 | 1x53 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM1 | Q | 44 | 1x53 | G.H5 | E | 392 | G.H5.24 |
Polar | ICL3 | Y | 207 | - | G.H5 | R | 385 | G.H5.17 |
Aromatic | ICL3 | Y | 207 | - | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | ICL3 | Y | 207 | - | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | ICL3 | Y | 207 | - | G.H5 | R | 385 | G.H5.17 |
Polar | TM1 | L | 49 | 1x58 | G.HN | Q | 35 | G.HN.52 |
Hydrophobic | TM1 | L | 49 | 1x58 | G.HN | Q | 35 | G.HN.52 |
Van-der-waals | TM1 | L | 49 | 1x58 | G.HN | Q | 35 | G.HN.52 |
Polar | ICL1 | H | 53 | - | G.H5 | H | 387 | G.H5.19 |
Aromatic | ICL1 | H | 53 | - | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL1 | H | 53 | - | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | ICL1 | H | 53 | - | G.H5 | H | 387 | G.H5.19 |
Polar | ICL3 | S | 203 | - | G.H5 | D | 378 | G.H5.10 |
Hydrophobic | ICL3 | S | 203 | - | G.H5 | D | 378 | G.H5.10 |
Van-der-waals | ICL3 | S | 203 | - | G.H5 | D | 378 | G.H5.10 |
Polar | ICL3 | I | 206 | - | G.S6 | Y | 360 | G.S6.02 |
Hydrophobic | ICL3 | I | 206 | - | G.S6 | Y | 360 | G.S6.02 |
Van-der-waals | ICL3 | I | 206 | - | G.S6 | Y | 360 | G.S6.02 |
Polar | ICL1 | K | 54 | - | G.s2s3 | D | 215 | G.s2s3.01 |
Van-der-waals | ICL1 | K | 54 | - | G.s2s3 | D | 215 | G.s2s3.01 |
Hydrophobic | ICL1 | H | 53 | - | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | ICL1 | H | 53 | - | G.H5 | Y | 391 | G.H5.23 |
Aromatic | TM1 | Y | 51 | 1x60 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM1 | Y | 51 | 1x60 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM1 | Y | 51 | 1x60 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL3 | I | 206 | - | G.S6 | P | 361 | G.S6.03 |
Ionic | TM3 | K | 127 | 3x61 | G.H5 | D | 381 | G.H5.13 |
Polar | TM3 | K | 127 | 3x61 | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | TM3 | K | 127 | 3x61 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | ICL1 | H | 53 | - | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | ICL1 | H | 53 | - | G.H5 | L | 388 | G.H5.20 |
Polar | ICL3 | A | 210 | - | G.H5 | R | 389 | G.H5.21 |
Hydrophobic | ICL3 | A | 210 | - | G.H5 | R | 389 | G.H5.21 |
Van-der-waals | ICL3 | A | 210 | - | G.H5 | R | 389 | G.H5.21 |
Polar | TM1 | Y | 51 | 1x60 | G.hns1 | R | 38 | G.hns1.02 |
Aromatic | TM1 | Y | 51 | 1x60 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | TM1 | Y | 51 | 1x60 | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | TM1 | Y | 51 | 1x60 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | C-term | H | 327 | - | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | C-term | H | 327 | - | G.H5 | L | 394 | G.H5.26 |
Polar | TM2 | Q | 59 | 2x43 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM2 | Q | 59 | 2x43 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM2 | Q | 59 | 2x43 | G.H5 | L | 393 | G.H5.25 |
Polar | ICL1 | G | 52 | - | G.HN | Q | 35 | G.HN.52 |
Hydrophobic | ICL1 | G | 52 | - | G.HN | Q | 35 | G.HN.52 |
Van-der-waals | ICL1 | G | 52 | - | G.HN | Q | 35 | G.HN.52 |
Polar | C-term | C | 333 | - | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | C-term | C | 333 | - | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | ICL3 | G | 212 | - | G.H5 | R | 389 | G.H5.21 |
Hydrophobic | ICL3 | A | 210 | - | G.S6 | Y | 360 | G.S6.02 |
Van-der-waals | ICL3 | A | 210 | - | G.S6 | Y | 360 | G.S6.02 |
Polar | TM1 | L | 50 | 1x59 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | TM1 | L | 50 | 1x59 | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | TM1 | L | 50 | 1x59 | G.hns1 | R | 38 | G.hns1.02 |
Polar | ICL1 | R | 55 | - | G.HN | Q | 35 | G.HN.52 |
Van-der-waals | ICL1 | R | 55 | - | G.HN | Q | 35 | G.HN.52 |
Polar | ICL3 | G | 212 | - | G.h4s6 | Y | 358 | G.h4s6.20 |
Hydrophobic | ICL3 | G | 212 | - | G.h4s6 | Y | 358 | G.h4s6.20 |
Van-der-waals | ICL3 | G | 212 | - | G.h4s6 | Y | 358 | G.h4s6.20 |
Polar | TM3 | K | 127 | 3x61 | G.H5 | N | 377 | G.H5.09 |
Van-der-waals | TM3 | K | 127 | 3x61 | G.H5 | N | 377 | G.H5.09 |
Polar | C-term | C | 328 | - | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | C-term | C | 328 | - | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | C-term | C | 328 | - | G.H5 | L | 394 | G.H5.26 |
Polar | ICL3 | S | 203 | - | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM3 | Y | 116 | 3x50 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM1 | V | 48 | 1x57 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM1 | V | 48 | 1x57 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | ICL1 | G | 52 | - | G.hns1 | A | 39 | G.hns1.03 |
Van-der-waals | ICL1 | G | 52 | - | G.hns1 | A | 39 | G.hns1.03 |
Hydrophobic | ICL1 | K | 54 | - | G.S3 | V | 217 | G.S3.01 |
Van-der-waals | ICL1 | K | 54 | - | G.S3 | V | 217 | G.S3.01 |
Ionic | C-term | D | 330 | - | G.H5 | R | 389 | G.H5.21 |
Polar | C-term | D | 330 | - | G.H5 | R | 389 | G.H5.21 |
Hydrophobic | C-term | D | 330 | - | G.H5 | R | 389 | G.H5.21 |
Van-der-waals | C-term | D | 330 | - | G.H5 | R | 389 | G.H5.21 |
Hydrophobic | TM1 | L | 50 | 1x59 | G.HN | K | 34 | G.HN.51 |
Van-der-waals | TM1 | L | 50 | 1x59 | G.HN | K | 34 | G.HN.51 |
Hydrophobic | ICL3 | A | 210 | - | G.h4s6 | Y | 358 | G.h4s6.20 |
Van-der-waals | ICL3 | A | 210 | - | G.h4s6 | Y | 358 | G.h4s6.20 |
Polar | TM1 | L | 47 | 1x56 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | ICL3 | Y | 207 | - | G.S6 | Y | 360 | G.S6.02 |
Hydrophobic | ICL3 | K | 211 | - | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | ICL3 | K | 211 | - | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM1 | L | 47 | 1x56 | G.H5 | L | 393 | G.H5.25 |
Ionic | TM3 | K | 123 | 3x57 | G.H5 | D | 381 | G.H5.13 |
Polar | TM3 | K | 123 | 3x57 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | TM3 | K | 123 | 3x57 | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | TM3 | K | 123 | 3x57 | G.H5 | D | 381 | G.H5.13 |
Ionic | TM3 | K | 127 | 3x61 | G.H5 | D | 378 | G.H5.10 |
Polar | TM3 | K | 127 | 3x61 | G.H5 | D | 378 | G.H5.10 |
Van-der-waals | TM3 | K | 127 | 3x61 | G.H5 | D | 378 | G.H5.10 |
Hydrophobic | ICL3 | Y | 207 | - | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | ICL3 | Y | 207 | - | G.H5 | L | 394 | G.H5.26 |
Polar | ICL3 | E | 209 | - | G.h4s6 | Y | 358 | G.h4s6.20 |
Hydrophobic | ICL3 | E | 209 | - | G.h4s6 | Y | 358 | G.h4s6.20 |
Van-der-waals | ICL3 | E | 209 | - | G.h4s6 | Y | 358 | G.h4s6.20 |
Polar | ICL3 | K | 211 | - | G.H5 | R | 389 | G.H5.21 |
Hydrophobic | ICL3 | K | 211 | - | G.H5 | R | 389 | G.H5.21 |
Van-der-waals | ICL3 | K | 211 | - | G.H5 | R | 389 | G.H5.21 |
Hydrophobic | ICL1 | H | 53 | - | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | ICL1 | H | 53 | - | G.H5 | L | 393 | G.H5.25 |
Polar | TM1 | L | 50 | 1x59 | G.HN | Q | 35 | G.HN.52 |
Hydrophobic | TM1 | L | 50 | 1x59 | G.HN | Q | 35 | G.HN.52 |
Van-der-waals | TM1 | L | 50 | 1x59 | G.HN | Q | 35 | G.HN.52 |
Hydrophobic | ICL3 | I | 206 | - | G.S6 | C | 359 | G.S6.01 |
Van-der-waals | ICL3 | I | 206 | - | G.S6 | C | 359 | G.S6.01 |
Hydrophobic | TM1 | Y | 51 | 1x60 | G.HN | Q | 35 | G.HN.52 |
Van-der-waals | TM1 | Y | 51 | 1x60 | G.HN | Q | 35 | G.HN.52 |
Polar | TM1 | Y | 51 | 1x60 | G.hns1 | A | 39 | G.hns1.03 |
Hydrophobic | TM1 | Y | 51 | 1x60 | G.hns1 | A | 39 | G.hns1.03 |
Van-der-waals | TM1 | Y | 51 | 1x60 | G.hns1 | A | 39 | G.hns1.03 |