GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 72.3
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 21.0
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | L | 413 | - | G.hfs2 | V | 179 | G.hfs2.03 |
Hydrophobic | TM3 | V | 120 | 3x54 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | V | 120 | 3x54 | G.H5 | C | 351 | G.H5.23 |
Polar | TM3 | Y | 116 | 3x50 | G.H5 | F | 354 | G.H5.26 |
Polar | ICL3 | S | 205 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL3 | S | 203 | - | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL3 | I | 206 | - | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL3 | I | 206 | - | G.hns1 | A | 31 | G.hns1.02 |
Polar | ICL3 | S | 203 | - | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL3 | S | 203 | - | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | ICL3 | S | 203 | - | G.H5 | C | 351 | G.H5.23 |
Polar | C-term | T | 353 | - | G.H4 | K | 304 | G.H4.12 |
Hydrophobic | C-term | T | 353 | - | G.H4 | K | 304 | G.H4.12 |
Van-der-waals | C-term | T | 353 | - | G.H4 | K | 304 | G.H4.12 |
Hydrophobic | C-term | L | 386 | - | G.H3 | H | 248 | G.H3.07 |
Van-der-waals | C-term | L | 386 | - | G.H3 | H | 248 | G.H3.07 |
Polar | C-term | Q | 348 | - | G.HG | Q | 275 | G.HG.05 |
Hydrophobic | C-term | Q | 348 | - | G.HG | Q | 275 | G.HG.05 |
Van-der-waals | C-term | Q | 348 | - | G.HG | Q | 275 | G.HG.05 |
Hydrophobic | TM3 | K | 123 | 3x57 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | K | 123 | 3x57 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL3 | T | 204 | - | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | ICL3 | T | 204 | - | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL3 | A | 210 | - | G.s2s3 | K | 192 | G.s2s3.01 |
Hydrophobic | ICL3 | S | 203 | - | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL3 | Y | 207 | - | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL3 | Y | 207 | - | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | C-term | A | 350 | - | G.H5 | V | 335 | G.H5.07 |
Hydrophobic | ICL3 | Y | 207 | - | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | ICL3 | Y | 207 | - | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | ICL3 | P | 202 | - | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL3 | P | 202 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL3 | P | 202 | - | G.HN | E | 28 | G.HN.52 |
Van-der-waals | ICL3 | P | 202 | - | G.HN | E | 28 | G.HN.52 |
Van-der-waals | ICL3 | I | 206 | - | G.s2s3 | K | 192 | G.s2s3.01 |
Hydrophobic | C-term | S | 355 | - | G.H4 | L | 308 | G.H4.16 |
Van-der-waals | C-term | S | 355 | - | G.H4 | L | 308 | G.H4.16 |
Hydrophobic | TM3 | K | 123 | 3x57 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM3 | K | 123 | 3x57 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | C-term | L | 389 | - | G.H3 | K | 257 | G.H3.16 |
Polar | TM3 | K | 123 | 3x57 | G.H5 | K | 349 | G.H5.21 |
Van-der-waals | TM3 | K | 123 | 3x57 | G.H5 | K | 349 | G.H5.21 |
Polar | C-term | T | 352 | - | G.S6 | H | 322 | G.S6.04 |
Hydrophobic | C-term | T | 352 | - | G.S6 | H | 322 | G.S6.04 |
Van-der-waals | C-term | T | 352 | - | G.S6 | H | 322 | G.S6.04 |
Hydrophobic | ICL3 | Y | 207 | - | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | ICL3 | Y | 207 | - | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL3 | I | 206 | - | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | ICL3 | I | 206 | - | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | C-term | L | 386 | - | G.H3 | S | 252 | G.H3.11 |
Hydrophobic | TM3 | K | 123 | 3x57 | G.H5 | D | 350 | G.H5.22 |
Polar | ICL3 | S | 203 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | C-term | D | 330 | - | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | C-term | D | 330 | - | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | C-term | H | 337 | - | G.H5 | F | 334 | G.H5.06 |
Van-der-waals | C-term | H | 337 | - | G.H5 | F | 334 | G.H5.06 |
Hydrophobic | ICL3 | I | 206 | - | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | TM3 | F | 117 | 3x51 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM3 | F | 117 | 3x51 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL3 | I | 206 | - | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL3 | I | 206 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | TM3 | V | 120 | 3x54 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM3 | V | 120 | 3x54 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | ICL3 | T | 204 | - | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | ICL3 | T | 204 | - | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | C-term | A | 350 | - | G.H5 | N | 331 | G.H5.03 |
Polar | TM3 | Y | 116 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM3 | Y | 116 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM3 | Y | 116 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL3 | T | 204 | - | G.H5 | C | 351 | G.H5.23 |
Polar | C-term | Q | 348 | - | G.HG | K | 271 | G.HG.01 |
Hydrophobic | C-term | L | 389 | - | G.H3 | H | 256 | G.H3.15 |
Van-der-waals | C-term | L | 389 | - | G.H3 | H | 256 | G.H3.15 |
Hydrophobic | TM5 | V | 197 | 5x61 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | W | 402 | - | G.H2 | I | 212 | G.H2.08 |
Van-der-waals | C-term | W | 402 | - | G.H2 | I | 212 | G.H2.08 |
Polar | TM3 | R | 128 | 3x62 | G.HN | A | 27 | G.HN.51 |
Hydrophobic | TM3 | R | 128 | 3x62 | G.HN | A | 27 | G.HN.51 |
Van-der-waals | TM3 | R | 128 | 3x62 | G.HN | A | 27 | G.HN.51 |
Hydrophobic | ICL3 | A | 210 | - | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL3 | A | 210 | - | G.H5 | I | 344 | G.H5.16 |
Polar | C-term | E | 412 | - | G.hfs2 | T | 182 | G.hfs2.06 |
Hydrophobic | ICL3 | I | 206 | - | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | ICL3 | P | 202 | - | G.HN | A | 27 | G.HN.51 |
Van-der-waals | ICL3 | P | 202 | - | G.HN | A | 27 | G.HN.51 |
Hydrophobic | TM3 | A | 124 | 3x58 | G.H5 | C | 351 | G.H5.23 |
Ionic | TM3 | K | 127 | 3x61 | G.H5 | D | 350 | G.H5.22 |
Polar | TM3 | K | 127 | 3x61 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | TM3 | K | 127 | 3x61 | G.H5 | D | 350 | G.H5.22 |
Polar | C-term | V | 384 | - | G.H3 | H | 248 | G.H3.07 |
Ionic | ICL3 | E | 209 | - | G.hns1 | R | 32 | G.hns1.03 |
Polar | ICL3 | E | 209 | - | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL3 | E | 209 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | TM3 | Y | 116 | 3x50 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM3 | Y | 116 | 3x50 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM3 | V | 120 | 3x54 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM3 | V | 120 | 3x54 | G.H5 | L | 353 | G.H5.25 |
Polar | C-term | T | 353 | - | G.S6 | S | 321 | G.S6.03 |
Van-der-waals | C-term | T | 353 | - | G.S6 | S | 321 | G.S6.03 |